Enzyme-responsive strategy as a prospective cue to construct intelligent biomaterials for disease diagnosis and therapy

Gao, Bin; Wang, Xiaoyu; Li, Wenzhong; Feng, Yakai

doi:10.1039/d2bm00067a

Cited by 31 publications

(22 citation statements)

References 173 publications

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“…Enzyme-responsive wise biomaterials often have enzyme-sensitive backbones or biodegradable ester bonds as linkages, resulting in efficient controlled release behavior [71]. Although enzymes have received extensive attention in studies on their application as triggers in malignancies and cardiovascular diseases, their application in OA therapy is still in its infancy so far [101]. MMPs, one of the key enzymes in the deterioration of OA, are commonly manufactured by chondrocytes under inflammatory conditions and lead to cartilage erosion by breaking down type II collagen and aggrecan in the joint matrix [43].…”

Section: Enzyme-responsive Biomaterialsmentioning

confidence: 99%

Targeted and responsive biomaterials in osteoarthritis

Li¹,

Zhang²,

Han³

et al. 2023

Theranostics

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Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions and tissue lesions. The non-vascular environment and dense cartilage matrix in the joints tend to block drug penetration, resulting in low drug bioavailability. There is a desire to develop safer and more effective OA therapies to meet the challenges of an aging world population in the future. Biomaterials have achieved satisfactory results in improving drug targeting, prolonging the duration of action, and achieving precision therapy. This article reviews the current basic understanding of the pathological mechanisms and clinical treatment dilemmas of OA, summarizes and discusses the advances for different kinds of targeted and responsive biomaterials in OA, seeking to provide new perspectives for the treatment of OA. Subsequently, limitations and challenges in clinical translation and biosafety are analyzed to guide the development of future therapeutic strategies for OA. As the need for precision medicine rises over time, emerging multifunctional biomaterials based on tissue targeting and controlled release will become an irreplaceable part of OA management.

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Section: Enzyme-responsive Biomaterialsmentioning

confidence: 99%

Targeted and responsive biomaterials in osteoarthritis

Li¹,

Zhang²,

Han³

et al. 2023

Theranostics

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“…Importantly, the level of several enzymes in tumors significantly differs from that in normal tissues [ 96 ]. Thus, drug delivery platforms based on the enzyme-responsive strategy have been proposed and investigated for years [ 97 , 98 ]. In an enzyme-responsive in situ hydrogel system, the matrix must contain a chemical moiety which needs to be an enzyme-specific substrate or a substrate mimicking and accessible to the enzymatic active center.…”

Section: Classification Of Smart In Situ Hydrogelsmentioning

confidence: 99%

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

et al. 2022

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Cancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemotherapy agents. However, these treatments pose severe risks, including off-target toxic side effects, low drug accumulation and penetration at the tumor site, repeated administration, etc., leading to inadequate treatment and failure to meet patients’ needs. Arising from these challenges, a local regional anticancer strategy has been proposed to enhance therapeutic efficacy and concomitantly reduce systemic toxicity. With the advances in biomaterials and our understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.). Herein, we focus on the latest progress regarding various stimuli that cause phase transition and drug release from smart hydrogels in local regional anticancer therapy. Additionally, the challenges and future trends of the reviewed in situ smart hydrogels for local drug delivery are summarized and proposed.

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“…[104] There is evidence cathepsin B can also recognize and degrade specific amino acid sequences such as Phe-Lys, Val-Cit, Glu-Val-Cit, GFLG, and GGFG. [105][106][107] Accordingly, these amino acid sequences are frequently introduced into DDSs to trigger the release of drugs in the intracellular lysosomal environment.…”

Section: Enzyme-responsive Strategymentioning

confidence: 99%

Targeted Drug Delivery Systems for Eliminating Intracellular Bacteria

Feng

Chittò

Moriarty

et al. 2022

Macromolecular Bioscience

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The intracellular survival of pathogenic bacteria requires a range of survival strategies and virulence factors. These infections are a significant clinical challenge, wherein treatment frequently fails because of poor antibiotic penetration, stability, and retention in host cells. Drug delivery systems (DDSs) are promising tools to overcome these shortcomings and enhance the efficacy of antibiotic therapy. In this review, the classification and the mechanisms of intracellular bacterial persistence are elaborated. Furthermore, the systematic design strategies applied to DDSs to eliminate intracellular bacteria are also described, and the strategies used for internalization, intracellular activation, bacterial targeting, and immune enhancement are highlighted. Finally, this overview provides guidance for constructing functionalized DDSs to effectively eliminate intracellular bacteria.

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Enzyme-responsive strategy as a prospective cue to construct intelligent biomaterials for disease diagnosis and therapy

Abstract: Stimuli-responsive materials have been widely studied and applied in biomedical field. Under the stimulation of enzymes, the enzyme-responsive materials (ERMs) can be triggered to change their structures, properties and functions....

Cited by 31 publications

References 173 publications

Targeted and responsive biomaterials in osteoarthritis

Targeted and responsive biomaterials in osteoarthritis

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

Targeted Drug Delivery Systems for Eliminating Intracellular Bacteria

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