Multifunctional nanoreactors with nutrient consumption and ROS generation capabilities for antibacterial and skin repair

Abstract

Bacterial wound infection has brought a serious threat to human health and caused huge economic losses. Attempts to develop biomaterials with excellent antibacterial effects are meaningful to promote wound healing....

Nanotechnology connecting copper metabolism and tumor therapy

“…According to several studies, different malignant tumors have higher Cu contents than normal tissues 34 . Cu can stimulate angiogenesis, 35 which is necessary for the growth and metastasis of tumors, by activating angiogenic proteins like angiopoietin (Ang), vascular endothelial growth factor (VEGF), 36–39 fibroblast growth factor 1 (FGF1), 40 and interleukin‐1 (IL‐1), and promote angiogenesis 41–44 . Therefore, Cu‐ exhaustion‐related cancer therapy emerges at the historic moment.…”

“…34 Cu can stimulate angiogenesis, 35 which is necessary for the growth and metastasis of tumors, by activating angiogenic proteins like angiopoietin (Ang), vascular endothelial growth factor (VEGF), [36][37][38][39] fibroblast growth factor 1 (FGF1), 40 and interleukin-1 (IL-1), and promote angiogenesis. [41][42][43][44] Therefore, Cu-exhaustion-related cancer therapy emerges at the historic moment. However, with the deepening of research, researchers have shown that Cu buildup can potentially result in cell death or irreversible harm to cells, such as cuproptosis, [45][46][47] apoptosis, 48,49 pyroptosis, 50,51 and ferroptosis.…”

Designed synthesis of prussian blue@Cu-doped zinc phosphate nanocomposites for chemo/chemodynamic/photothermal combined cancer therapy

“…6,7 As an emerging therapeutic method, chemodynamic therapy (CDT) can be triggered by catalyzing endogenous overexpressed H 2 O 2 into hydroxyl radicals ( OH) via Fenton/Fenton-like reactions based on transition metal elements (e.g., Fe, Cu, Mn), exhibiting high tumor microenvironment specificity and biosafety, and has been of wide interest. [8][9][10][11] It is worth noting that the therapeutic effects of CDT can be constrained by finite H 2 O 2 concentrations and an unbreakable tumor antioxidant system. 12 In this regard, Cu 2+ ions are suitable for CDT, because they can react with overexpressed antioxidant glutathione (GSH) in a tumor microenvironment, and the generated Cu + ions further efficiently catalyze a Fenton-like reaction in weakacid media.…”

A double cross-linked hydrogel based on water-soluble chitosan and oxidized hyaluronic acid as an antibacterial dressing

“…Bacterial infection is a huge threat to wound healing, causing a delay in the healing process. [1][2][3] Severe bacterial infection can lead to tissue damage and even death. 4,5 As representatives of traditional dressings, bandages, and gauze have an extremely high usage rate in clinical treatment due to their convenience.…”