Designed synthesis of prussian blue@Cu-doped zinc phosphate nanocomposites for chemo/chemodynamic/photothermal combined cancer therapy

Abstract

Designing a multifunctional nanoplatform that combines multiple treatments has emerged as an innovative cancer treatment strategy. A simple and clear route is put forward to develop Cu2+-doped zinc phosphate coated...

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

“…Additionally, the PDA component in Fe-PDA-EPI@FA-RBCm nanoparticles can absorb NIR light and convert it into heat, raising the temperature of the surrounding environment and accelerating the progress of the Fenton reaction. The research group led by Hu synthesized Cu 2+ -doped zinc phosphate-coated Prussian blue nanoparticles (PB@Cu 2+ /ZnP NPs) [ 113 ] ( Figure 15 ). Under near-infrared (NIR) irradiation, the PB core of these nanoparticles generates significant heat, enabling efficient photothermal therapy.…”

“…Simultaneously, the shell of the nanoparticles, composed of Cu 2+ -doped ZnP, gradually degrades and releases DOX and Cu 2+ in the tumor microenvironment, which is slightly acidic. The released Cu 2+ reacts with the intracellular antioxidant glutathione (GSH), generating Cu + and further catalyzing the Fenton reaction, thereby disrupting the internal balance of the tumor cells and achieving tumor cell destruction [ 113 ]. This research proposes a new strategy for constructing a multimodal therapy, offering potential for tumor treatment.…”