Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement

Park, Huiyul; Yang, Jaemoon; Seo, Sungbaek; Kim, Kyujung; Suh, Jin Suck; Kim, Dong-Hyun; Haam, Seungjoo; Yoo, Kyung Hwa

doi:10.1002/smll.200700807

Cited by 152 publications

(93 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Polyester-based materials, such as poly(lactide-co-glycolide) (PLGA), were once used solely for their controllable biodegradation capabilities but are now being modified, both chemically and physically, in order to meet demanding device requirements. PLGA materials are now not only used as delivery vehicles for drugs and other therapies but also;in manipulated forms;to target cancer, 1 molded into load-bearing geometries such as a screw, 2 to image targeted areas, 3 and can be switched from a temporary shape into a permanent shape through heat or other stimulation. 4,5 This last property, called shape memory, allows for unique possibilities.…”

Section: Introductionmentioning

confidence: 99%

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

et al. 2009

View full text Add to dashboard Cite

Biodegradable PLGA oligomers were synthesized to feature a hybrid organic-inorganic moiety, POSS, incorporated at the center of each chain by using it as the ring-opening initiator. After end-capping with vinyl groups, the macromers were photocured into networks with POSS content ranging from 10 to 41 wt %. Increasing POSS inclusion increased the crystallinity of the network while decreasing the degradation rate due to its hydrophobic and nonhydrolyzable properties. It was found that co-curing PLGA oligomers with and without POSS in the backbone could be utilized to create networks with a reduced POSS loading level, at a given cross-link density, allowing tuned crystallinity. Hydrolytic degradation of the co-cured networks was slower than for the PLGA homonetwork but still led to complete degradation after 14 weeks in PBS buffer at 37°C. The networks exhibited versatile shape memory properties, exploiting the combination of covalent cross-linking and the glass transition, POSS-phase melting temperature, or both as the shape-switching trigger. Using the glass transition was found to yield the best shape fixing, while the best recovery percentages (∼100%) were achieved when the melting transition was used. One network, with 24 wt % POSS, was able to be fixed in a temporary shape by POSS crystallization and to largely preserve this shape during degradation. After 4 weeks and 60% mass loss, 50% of the initial deformation still remained while the PLGA network (shape fixed through T g ) had recovered fully. Our findings are expected to impact future design of biodegradable polymers with shape memory, having revealed the precise tuning of properties possible through controlled placement of a crystallizable and hydrophobic moiety in the polymer network chain.

show abstract

Section: Introductionmentioning

confidence: 99%

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Interestingly, intense characteristic emissions are observed at the near-infrared regions (800 to 1,400 nm). Recently, NIR irradiation combined with NIR absorbing agents play a crucial role in the biomedical applications of anticancer treatment, hyperthermia therapy, and in vivo molecular imaging (Park et al 2009;Lee et al 2010;Park et al 2010;Park et al 2008). This is because the NIR light can penetrate deeply into the skin tissue and then this enables local heating to destroy target cancer cells by the assistance of NIR absorber and heating complex agents.…”

Section: Resultsmentioning

confidence: 99%

Optical characteristics and photothermal conversion of natural iron oxide colloid

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Once shutting off the light source, DOX release was negligible. When radiated by NIR light again, quick drug release was observed immediately, indicating that the drug release from the NCs-DOX could be manipulated simply by controlling the NIR light irradiation [65]. In another aspect, the repeated drug release also implies that the photothermal response of Cu 7 S 4 NPs is very stable [66], allowing for drug release for multicycles.…”

Section: Photothermal Performancementioning

confidence: 99%

Photothermo-responsive Cu7S4@polymer nanocarriers with small sizes and high efficiency for controlled chemo/photothermo therapy

Bai

et al. 2016

Sci. China Mater.

View full text Add to dashboard Cite

Drug delivery systems (DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment efficacy and reducing side effects faces great challenge. We report a kind of "smart" nanocomposites (NCs) that is sensitive to the surrounding temperature by grafting a layer of thermosensitive polymer, poly(N-isopropylacrylamide) (pNIPAm), on the surface of single Cu7S4 nanoparticle (NP) via atomtransfer radical polymerization (ATRP). These NCs demonstrate a photothermal conversion efficiency of 25.4% under 808-nm near infrared (NIR) light irradiation and a drug loading content of 19.4% (drug/total NCs, w/w) with a lower critical solution temperature (LCST) of~38°C. At normal physiological temperature (37°C), only 10.8% of the loaded doxorubicin (DOX) was released at physiological pH value (pH 7.4) within 10 h. In the presence of 808-nm irradiation, due to the temperature increment as a result of photothermal effects, DOX was rapidly released.

show abstract

Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement

Cited by 152 publications

References 20 publications

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

PLGA−POSS End-Linked Networks with Tailored Degradation and Shape Memory Behavior

Optical characteristics and photothermal conversion of natural iron oxide colloid

Photothermo-responsive Cu7S4@polymer nanocarriers with small sizes and high efficiency for controlled chemo/photothermo therapy

Contact Info

Product

Resources

About