Multifunctional nanoparticle composites: progress in the use of soft and hard nanoparticles for drug delivery and imaging

Sangtani, Ajmeeta; Nag, Okhil K.; Field, Lauren D.; Breger, Joyce C.; Delehanty, James B.

doi:10.1002/wnan.1466

Cited by 59 publications

(46 citation statements)

References 130 publications

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“…In vivo imaging presents great opportunities for both clinical diagnostics and treatment, and enables us to “look” deeply within living subjects . Continuous advances in the synthesis of nanoparticles, as well as their application in biological systems, has resulted in an exponential growth in their use for bioimaging, drug delivery, and theranostic applications . This section surveys the latest status of multifunctional nanoparticles for in vivo studies and applications, providing insight on the most promising aspects and on potential future directions.…”

Section: Nanoparticles For In Vivo Bioimaging and Theranosticsmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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141

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Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.

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Section: Nanoparticles For In Vivo Bioimaging and Theranosticsmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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141

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“…Nanotechnology has received significant attention in biomedicine over the past decade because of the unique physicochemical properties of nanoparticles (Anchordoquy et al, ; Medina‐Reyes, Garcia‐Viacobo, Carrero‐Martinez, & Chirino, ; Sangtani, Nag, Field, Breger, & Delehanty, ). Iron oxide nanoparticles are promising biomedical nanomaterials, primarily because of their relative safety and magnetic properties (Arami, Khandhar, Liggitt, & Krishnan, ; Patil et al, ).…”

Section: Introductionmentioning

confidence: 99%

Impairment of mitochondrial dynamics involved in iron oxide nanoparticle‐induced dysfunction of dendritic cells was alleviated by autophagy inhibitor 3‐methyladenine

Zhang

Zhou

Wang

et al. 2020

J of Applied Toxicology

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Iron oxide nanoparticles are nanomaterials that are used extensively in the biomedical field, but they are associated with adverse effects, including mitochondrial toxicity. Mitochondrial homeostasis is achieved through dynamic stability based on two sets of antagonistic balanced processes: mitochondrial biogenesis and degradation as well as mitochondrial fission and fusion. In this study, we showed that PEG-COOH-coated Fe 3 O 4 (PEG-Fe 3 O 4 ) nanoparticles induced mitochondrial instability in dendritic cells (DCs) by impairing mitochondrial dynamics due to promotion of mitochondrial biogenesis through activation of the peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) pathway, inhibiting mitochondrial degradation via decreased autophagy, and facilitating mitochondrial fragmentation involving increased levels of DRP1 and MFN2. The resulting reduced levels of dextran uptake, CD80, CD86 and chemokine receptor 7 (CCR7) suggested that PEG-Fe 3 O 4 nanoparticles impaired the functionally immature state of DCs. Autophagy inhibitor 3-methyladenine (3-MA) alleviated PEG-Fe 3 O 4 nanoparticleinduced mitochondrial instability and impairment of the functionally immature state of DCs due to unexpected enhancement of PGC1α/MFN2-mediated coordination of mitochondrial biogenesis and fusion.

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“…In addition, optical tools, including fluorescence imaging (FI) and bioluminescence imaging, have become popular because of their low cost. [14][15][16][17] A variety of multimodal nanoprobes have been synthesized for molecular imaging in medical research. [18][19][20][21][22] Among them, dual-modal fluorescence imaging/magnetic resonance imaging (FI/MRI) agents exhibit impressive advantages and have attracted many researchers' attention for years.…”

Section: Introductionmentioning

confidence: 99%

Glypican-1-antibody-conjugated Gd-Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer

Huang¹,

Fan²,

Zhu³

et al. 2018

IJN

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IntroductionPancreatic cancer (PC) has a poor prognosis with high mortality, due to the lack of effective early diagnostic and prognostic tools.Materials and methodsIn order to target and diagnose PC, we developed a dual-modal imaging probe using Glypican-1 (GPC-1) antibody conjugated with Gd–Au nanoclusters (NCs; Gd-Au-NC-GPC-1). GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC. The probe was successfully prepared with a hydrodynamic diameter ranging from 13.5 to 24.4 nm.ResultsSpectral characteristics showed absorption at 280 nm and prominent emission at 650 nm. Confocal microscopic imaging showed effective detection of GPC-1 highly expressed PC cells by Gd-Au-NC-GPC-1, which was consistent with flow cytometry results. In vitro relaxivity characterization demonstrated that the r1 value of the probe was 17.722 s−1 mM−1 Gd, which was almost 4 times higher compared with that of Gd-diethylenetriaminepentacetate (DTPA; r1 value =4.6 s−1 mM−1 Gd). Gd-Au-NC-GPC-1 exhibited similar magnetic resonance (MR) signals when compared to Gd-DTPA even at lower Gd concentrations. Much higher MR signals were registered in PC cells (COLO-357) compared with normal cells (293T). Furthermore, Gd-Au-NC-GPC-1 could effectively detect PC cells in vivo by dual-modal fluorescence imaging/magnetic resonance imaging (FI/MRI) at 30 minutes postinjection. In addition, Gd-Au-NC-GPC-1 did not show significant biotoxicity to normal cells at tested concentrations both in vitro and in vivo.ConclusionGd-Au-NC-GPC-1 has demonstrated to be a promising dual-modal FI/MRI contrast agent for targeted diagnosis of PC.

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Multifunctional nanoparticle composites: progress in the use of soft and hard nanoparticles for drug delivery and imaging

Cited by 59 publications

References 130 publications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impairment of mitochondrial dynamics involved in iron oxide nanoparticle‐induced dysfunction of dendritic cells was alleviated by autophagy inhibitor 3‐methyladenine

Glypican-1-antibody-conjugated Gd-Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer

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