Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye

Xu, Chunxiao; Lu, Jinhui; Zhou, Li; Liang, Jie; Fang, Lei; Cao, Feng

doi:10.1016/j.carbpol.2021.117800

Cited by 18 publications

(5 citation statements)

References 61 publications

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“…For example, pristine LDH surface was grafted with 3-(aminopropyl)-triethoxysilane (APTES) and intercalation of dexamethasone-carboxymethyl-b-cyclodextrin (DEX-CM-b-CD) took place via anion exchange (Fig. 7) [155]. The cyclodextrin loading resulted in a decrease in zeta potential and increase in size compared to the pristine LDH indicating the successful intercalation of the guest macromolecules.…”

Section: Gu Et Al Intercalated Low Molecular Weight Heparin By Addingmentioning

confidence: 99%

“…The first route is easily achievable due to ability to exchange layer forming cations with other ones of a similar radius, while the latter is feasible due to elevated LDH ionexchange capacity. Applications of LDH substances and their derivatives include bioimaging [121,147,185], cosmetic [186] and therapeutic applications [77,173], development of novel drug and gene delivery platforms [155,187], tissue engineering [188][189][190], material science [1,4,191] and various sensing schemes based on LDH nanoparticles [192][193][194]. Below, we will focus on those involving LDH-biopolymer hybrids during materials preparation or functionalization.…”

Section: Biomedical Applications Of Ldh-biopolymer Hybridsmentioning

confidence: 99%

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Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Pavlović

Szerlauth

Muráth

et al. 2022

Advanced Drug Delivery Reviews

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Section: Gu Et Al Intercalated Low Molecular Weight Heparin By Addingmentioning

confidence: 99%

Section: Biomedical Applications Of Ldh-biopolymer Hybridsmentioning

confidence: 99%

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Pavlović

Szerlauth

Muráth

et al. 2022

Advanced Drug Delivery Reviews

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“…hydrogen bond, π-π interactions, ionic and dipolar interactions, hydrophobic force, host-guest and van der Waals interactions) contribute to the formation of the inclusion behavior [31]. Xu et al prepared the intercalation of anion carboxymethyl β-CyD (CM-β-CyD) into layered double hydroxide (LDH) using anionic exchange method [43]. Meanwhile, the inner cavity of β-CyD could also retain drugs like dexamethasone (DEX) and avoid leakage.…”

Section: Without Any Modificationmentioning

confidence: 99%

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

Chen¹,

Zheng²,

Tian³

et al. 2023

Preprint

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Drug delivery systems consist of cyclodextrins (CyDs) have kept constant attention for good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. The unique hollow structure has endowed a lot of functions, such as inclusion of guest molecules, functional modification of active hydroxyl groups, and noncovalent interactions. Besides, the polyhydroxy structure has further extended the functions of CyDs by inter/intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to physicochemical characteristics alteration of the drugs, therapeutic talent, stimulus-responsive switch, self-assemble capability, and fiber formation. This review attempts to list the recent progress of CyDs and discuss their roles in the drug delivery system. Future perspectives of the construction of CyD-based drug delivery systems are also discussed at the end of this review, which may be the possible directions for the construction of more rational and cost-effective delivery vehicles.

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“…The interactions between CyDs and guest molecules (i.e., hydrogen bond, π-π interactions, ionic and dipolar interactions, hydrophobic force, host-guest, and van der Waals interactions) contribute to the formation of the inclusion behavior [ 30 ]. Xu et al prepared the intercalation of anion carboxymethyl β-CyD (CM-β-CyD) into layered double hydroxide (LDH) using an anionic exchange method [ 38 ]. Meanwhile, the inner cavity of β-CyD could also retain drugs like dexamethasone (DEX) and avoid leakage.…”

Section: Applicationmentioning

confidence: 99%

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

et al. 2023

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Cyclodextrins (CyDs) in nano drug delivery systems have received much attention in pursuit of good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. Their unique internal cavity has widened the application of CyDs in drug delivery based on its advantages. Besides this, the polyhydroxy structure has further extended the functions of CyDs by inter- and intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to alteration of the physicochemical characteristics of the drugs, significant therapeutic promise, a stimulus-responsive switch, a self-assembly capability, and fiber formation. This review attempts to list recent interesting strategies regarding CyDs and discusses their roles in nanoplatforms, and may act as a guideline for developing novel nanoplatforms. Future perspectives on the construction of CyD-based nanoplatforms are also discussed at the end of this review, which may provide possible direction for the construction of more rational and cost-effective delivery vehicles.

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Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye

Cited by 18 publications

References 61 publications

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

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