Multifunctional nanoclusters of NaYF4:Yb3+,Er3+ upconversion nanoparticle and gold nanorod for simultaneous imaging and targeted chemotherapy of bladder cancer

Cho, Suehyun K.; Su, Lih-Jen; Mao, Chongchang; Wolenski, Connor; Flaig, Thomas W.; Park, Won

doi:10.1016/j.msec.2018.12.113

Cited by 39 publications

(27 citation statements)

References 47 publications

(17 reference statements)

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“…Through optoporation-assisted chemotherapy, the system could significantly reduce the effective dosage of cisplatin. The constructed nanoparticles showed great potential in clinical application [ 110 ].…”

Section: Multifunctional Nanoparticlesmentioning

confidence: 99%

Application of nanotechnology in the diagnosis and treatment of bladder cancer

Luo

Wang

et al. 2021

J Nanobiotechnol

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Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for management improvements in clinic. Nanotechnology has been proposed as an effective method to improve theranosis efficiency for both non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). For example, gold nanoparticles (AuNPs) have been developed for simple, fast and sensitive urinary sample test for bladder cancer diagnosis. Nanoparticles targeting bladder cancers can facilitate to distinguish the normal and abnormal bladder tissues during cystoscopy and thus help with the complete removal of malignant lesions. Both intravenous and intravesical agents can be modified by nanotechnology for targeted delivery, high anti-tumor efficiency and excellent tolerability, exhibiting encouraging potential in bladder cancer treatment. Photosensitizers and biological agents can also be delivered by nanotechnology, intermediating phototherapy and targeted therapy. The management of bladder cancer remained almost unchanged for decades with unsatisfactory effect. However, it is likely to change with the fast-developed nanotechnology. Herein we summarized the current utility of nanotechnology in bladder cancer diagnosis and treatment, providing insights for the future designing and discovering novel nanoparticles for bladder cancer management. Graphical Abstract

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Section: Multifunctional Nanoparticlesmentioning

confidence: 99%

Application of nanotechnology in the diagnosis and treatment of bladder cancer

Luo

Wang

et al. 2021

J Nanobiotechnol

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“…In cell experiments, functionalized nanoclusters exerted obvious cytotoxic effects relative to those without antibody modifications. The use of monoclonal antibodies to modify nanocarriers is proposed to effectively reduce the dosage and maximize the therapeutic effects of drugs ( Cho et al, 2019 ).…”

Section: Specific Targeted Therapeutic Nanocarriers For Bladder Cancermentioning

confidence: 99%

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

et al. 2021

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Bladder cancer is one of most common malignant urinary tract tumor types with high incidence worldwide. In general, transurethral resection of non-muscle-invasive bladder cancer followed by intravesical instillation of chemotherapy is the standard treatment approach to minimize recurrence and delay progression of bladder cancer. However, conventional intravesical chemotherapy lacks selectivity for tumor tissues and the concentration of drug is reduced with the excretion of urine, leading to frequent administration and heavy local irritation symptoms. While nanomedicines can overcome all the above shortcomings and adhere to the surface of bladder tumors for a long time, and continuously and efficiently release drugs to bladder cancers. The rapid advances in targeted therapy have led to significant improvements in drug efficacy and precision of targeted drug delivery to eradicate tumor cells, with reduced side-effects. This review summarizes the different available nano-systems of targeted drug delivery to bladder cancer tissues. The challenges and prospects of targeted therapy for bladder cancer are additionally discussed.

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“…In order to improve the efficiency of targeted binding by antibody, Cho constructed an imaging-guided therapeutic UCNPs with shell of Au nanorod by PEGylation process. 122 The C-225 antibody was further attached to the NaYF 4 NPs-Au to target epidermal growth factor receptor (EGFR) overexpressed bladder cancer cells. Within 2 h of incubation, it can target binding to EGFR-positive cancer cells rather than EGFR-negative cells.…”

Section: Tumor Therapymentioning

confidence: 99%

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

et al. 2020

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Rare earth-doped nanoparticles have been widely used in disease diagnosis, drug delivery, tumor therapy, and bioimaging. Among various bioimaging methods, the fluorescence imaging technology based on the rare earth-doped nanoparticles can visually display the cell activity and lesion evolution in living animals, which is a powerful tool in biological technology and has being widely applied in medical and biological fields. Especially in the band of near infrared (700–1700 nm), the emissions show the characteristics of deep penetration due to low absorption, low photon scattering, and low autofluorescence interference. Furthermore, the rare earth-doped nanoparticles can be endowed with the water solubility, biocompatibility, drug-loading ability, and the targeting ability for different tumors by surface functionalization. This confirms its potential in the cancer diagnosis and treatment. In this review, we summarized the recent progress in the application of rare earth-doped nanoparticles in the field of bioimaging and tumor treatment. The luminescent mechanism, properties, and structure design were also discussed.

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Multifunctional nanoclusters of NaYF4:Yb3+,Er3+ upconversion nanoparticle and gold nanorod for simultaneous imaging and targeted chemotherapy of bladder cancer

Cited by 39 publications

References 47 publications

Application of nanotechnology in the diagnosis and treatment of bladder cancer

Application of nanotechnology in the diagnosis and treatment of bladder cancer

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

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