Multifunctional MoS2 composite nanomaterials for drug delivery and synergistic photothermal therapy in cancer treatment

Liu, Jiamei; Lu, Kaida; Gao, Fucheng; Zhao, Li; Li, Hui; Jiang, Yanyan

doi:10.1016/j.ceramint.2022.04.244

Cited by 16 publications

(6 citation statements)

References 51 publications

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“…After loading with DOX, MoS 2 –PEI–HA–DOX could release drugs in the tumor acidic microenvironment and be guided by PET imaging for cancer chemotherapy. Similarly, Liu et al 247 . reported an MoS 2 composite nanosheet material BBPL–MoS 2 –LP, in which the lipoic acid (LA)–PEG and LA–PEI‐modified MoS 2 was combined with biotin–BSA through amide bonds and loaded DOX to achieve synergistic targeted chemo‐PTT.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 98%

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Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 98%

“…Similarly, Liu et al. 247 reported an MoS 2 composite nanosheet material BBPL–MoS 2 –LP, in which the lipoic acid (LA)–PEG and LA–PEI‐modified MoS 2 was combined with biotin–BSA through amide bonds and loaded DOX to achieve synergistic targeted chemo‐PTT.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…Increasingly, MoS 2 is used to treat cancer due to its excellent photothermal properties. According to Liu et al, a novel MoS 2 composite nanosheet was synthesized with a lamellar structure and good water solubility, which was highly photothermal-converting and biocompatible [122]. On composite nanosheets, DOX was loaded at 34.43%.…”

Section: Mos 2 -Based Therapy 431 Mos 2 -Based Drug Deliverymentioning

confidence: 99%

MoS₂ nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications

Harini,

Girigoswami,

Pallavi

et al. 2023

Nano Futures

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The unique physicochemical properties of MoS2 nanocomposites have drawn escalation in attention for the diagnosis and therapy of cancer. Mostly the 2D forms of MoS2 find application in sensing, catalysis, and theranostics, where it was traditionally applied in lubrication and battery industries as electrodes or intercalating agents. As nanostructures, MoS2 has a very high surface-to-volume ratio, and that helps in the engineering of structures and surfaces to promote absorption of a wide range of therapeutics and biomolecules through covalent or non-covalent interaction. This surface engineering provides excellent colloidal stability to MoS2 and makes them ideal nanomedicines with higher selectivity, sensitivity, and biomarker sensing ability. Furthermore, MoS2 exhibits exceptionally well optical absorption of NIR radiation and photothermal conversion, which helps in the NIR-responsive release of payloads in photothermal and photodynamic therapy. There are several reports that the fabricated MoS2 nanomedicines can selectively counter the tumor microenvironment, which leads to the accumulation of therapeutics or imaging agents in the diseased tissues to improve the therapeutic effects decreasing the adverse effects on the healthy cells. An overview of the basic structure and properties of MoS2 is presented in this article, along with an elaborative description of its morphology. At the same time, an attempt was made in this review to summarize the latest developments in the MoS2 structure, surface engineering, and nanocomposite formulations for improving biocompatibility, bioavailability, biomolecular sensing, and theranostic applications.

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“…The increase in cell temperature causes enzyme release and cell lysis, leading to cell necrosis, protein denaturation, and cancer cell death [ 13 ]. Some photothermal agents have significant drawbacks, including high cost, poor photothermal stability, low photothermal conversion efficiency, and the possibility of toxicity and adverse effects [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

et al. 2023

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Conventional cancer therapies, such as radiotherapy and chemotherapy, can have long-term side effects. Phototherapy has significant potential as a non-invasive alternative treatment with excellent selectivity. Nevertheless, its applicability is restricted by the availability of effective photosensitizers and photothermal agents, and its low efficacy when it comes to avoiding metastasis and tumor recurrence. Immunotherapy can promote systemic antitumoral immune responses, acting against metastasis and recurrence; however, it lacks the selectivity displayed by phototherapy, sometimes leading to adverse immune events. The use of metal-organic frameworks (MOFs) in the biomedical field has grown significantly in recent years. Due to their distinct properties, including their porous structure, large surface area, and inherent photo-responsive properties, MOFs can be particularly useful in the fields of cancer phototherapy and immunotherapy. MOF nanoplatforms have successfully demonstrated their ability to address several drawbacks associated with cancer phototherapy and immunotherapy, enabling an effective and low-side-effect combinatorial synergistical treatment for cancer. In the coming years, new advancements in MOFs, particularly regarding the development of highly stable multi-function MOF nanocomposites, may revolutionize the field of oncology.

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Multifunctional MoS2 composite nanomaterials for drug delivery and synergistic photothermal therapy in cancer treatment

Cited by 16 publications

References 51 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

MoS₂ nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

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Multifunctional MoS2 composite nanomaterials for drug delivery and synergistic photothermal therapy in cancer treatment

Cited by 16 publications

References 51 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

MoS2 nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

Contact Info

Product

Resources

About

MoS₂ nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications