Multifunctional MOF‐Based Microneedle Patch With Synergistic Chemo‐Photodynamic Antibacterial Effect and Sustained Release of Growth Factor for Chronic Wound Healing

Abstract

Chronic wound healing is a major challenge in biomedicine. Conventional therapies are usually associated with poor drug permeability, low bioavailability, risk of antimicrobial resistance, and require frequent administration. Therefore, a novel formulation with reduced antibiotic dosage, improved drug delivery efficiency, and low application frequency is of remarkable interest for chronic wound healing. Herein, a multifunctional microneedle (MN) patch is presented to achieve rapid wound healing via efficient chemo-photodynamic antibacterial effect and sustained release of growth factors at the wound bed. When the MN patch pierces the skin, MN tips carrying both low dosage of antibiotics and bioactive small molecule-encapsulated metal-organic frameworks (MOFs) rapidly dissolve and subsequently deliver the payloads to the wound. Upon light irradiation, MOF-based nanoparticles robustly convert O 2 into 1 O 2 , which acts synergistically with chemotherapy to remove pathogenic bacteria from the wound, exhibiting excellent chemo-photodynamic antibacterial performance with a tenfold reduction in the required antibiotic amount. The nanoparticles can achieve a continuous release of growth factors in the wound tissue, promoting the formation of epithelial tissue and neovascularization, thereby further accelerating chronic wound healing. Collectively, the designed multifunctional MOF-based MN patches offer a simple, safe, and effective alternative for chronic wound management.

Multifunctional MXene-doped photothermal microneedles for drug-resistant bacteria-infected wound healing

“…The repair and regeneration of the epithelium are a significant guarantee of skin integrity and play a crucial role in the process of wound healing. 46,47 In addition to visual observation, the tissue changes during the wound healing process were further evaluated via H&E staining (Fig. 8d and e).…”

Microneedle systems: cell, exosome, and nucleic acid based strategies

“…Current research focuses on the local delivery of photosensitizers in photodynamic therapy to minimize systemic uptake and enhance the treatment of infected wounds, tumors, and hyperplastic scarring. 34,35 An important aspect of soluble MNs is the use of materials with different dissolution rates. This allows for sequential therapy, where fast-dissolving components provide rapid symptomatic relief while slow-dissolving components target specific disease conditions.…”

Chlorella‐Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds

“…Therefore, effective elimination of microbes and regulation of the wound microenvironment are critical for the treatment of chronic diabetic wounds. Antibiotics, [ 8 ] therapeutic gases, [ 9,10 ] cationic polymers, [ 11–13 ] and biologically active species [ 14,15 ] have been used to eliminate microbes in chronic wounds. Thereinto, cationic poly(ionic liquid) (PIL), a substance that is not prone to inducing bacterial resistance, has been used to treat bacterial infections.…”