Microneedle systems: cell, exosome, and nucleic acid based strategies

Zhang, Shufei; Yang, Lian; Liu, Jianfeng; Li, Hanyue; Hong, Shasha; Hong, Li

doi:10.1039/d3bm01103h

Cited by 3 publications

(1 citation statement)

References 86 publications

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“…To preserve the biological activity of EVs and control their release during long-term damage repair, the use of biocompatible biomaterials or biological devices for EV delivery has been extensively explored [ 182 ]. MNs emerge as a promising strategy for efficient EV delivery, combining minimally invasive and intelligent modulation properties with the pro-angiogenic, pro-tissue regeneration, and anti-inflammatory properties of EVs, presenting a promising avenue for therapeutic applications [ 13 , 183 , 184 ].…”

Section: Extracellular Vesicles-loaded Microneedles: a Promising Dire...mentioning

confidence: 99%

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Wang,

Cheng,

2024

Pharmaceutics

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Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential for facilitating effective drug delivery, vaccination, and targeted sample extraction. Extracellular vesicles (EVs), serving as cargo for MNs, are naturally occurring nanovesicles secreted by cells and characterized by novel biomarkers, low immunogenicity, and cell-source-specific traits. MNs prove instrumental in extracting EVs from the sample fluid, thereby facilitating a promising diagnostic and prognostic tool. To harness the therapeutic potential of EVs in tissue repair, MNs with sustained delivery of EVs leverage micron-sized channels to enhance targeted site concentration, demonstrating efficacy in treating various diseases, such as Achillea tendinopathy, hair loss, spinal cord injury, and diabetic ulcers. EV-loaded MNs emerge as a promising platform for repair applications of skin, cardiac, tendon, hair, and spinal cord tissues. This review commences with an overview of MNs, subsequently delving into the role of EVs as cargo for MNs. The paper then synthesizes the latest advancements in the use of EV-loaded MNs for tissue regenerative repair, extending to research progress in extracting EVs from MNs for disease diagnosis and prognostic evaluations. It aims to offer valuable insights and forecast future research trajectories with the hope of inspiring innovative ideas among researchers in this field.

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Section: Extracellular Vesicles-loaded Microneedles: a Promising Dire...mentioning

confidence: 99%

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Wang,

Cheng,

2024

Pharmaceutics

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Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices

Babu,

Vishwas,

Khursheed

et al. 2023

Drug Deliv. and Transl. Res.

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Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review

Duval,

Wyse,

Tsang

et al. 2024

J Ovarian Res

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Extracellular vesicles (EVs), particles enriched in bioactive molecules like proteins, nucleic acids, and lipids, are crucial mediators of intercellular communication and play key roles in various physiological and pathological processes. EVs have been shown to be involved in ovarian follicular function and to be altered in two prevalent gynecological disorders; polycystic ovarian syndrome (PCOS) and endometriosis. Ovarian follicles are complex microenvironments where folliculogenesis takes place with well-orchestrated interactions between granulosa cells, oocytes, and their surrounding stromal cells. Recent research unveiled the presence of EVs, including exosomes and microvesicles, in the follicular fluid (FFEVs), which constitutes part of the developing oocyte’s microenvironment. In the context of PCOS, a multifaceted endocrine, reproductive, and metabolic disorder, studies have explored the dysregulation of these FFEVs and their cargo. Nine PCOS studies were included in this review and two miRNAs were commonly reported in two different studies, miR-379 and miR-200, both known to play a role in female reproduction. Studies have also demonstrated the potential use of EVs as diagnostic tools and treatment options. Endometriosis, another prevalent gynecological disorder characterized by ectopic growth of endometrial-like tissue, has also been linked to aberrant EV signaling. EVs in the peritoneal fluid of women with endometriosis carry molecules that modulate the immune response and promote the establishment and maintenance of endometriosis lesions. EVs derived from endometriosis lesions, serum and peritoneal fluid obtained from patients with endometriosis showed no commonly reported biomolecules between the eleven reviewed studies. Importantly, circulating EVs have been shown to be potential biomarkers, also reflecting the severity of the pathology. Understanding the interplay of EVs within human ovarian follicles may provide valuable insights into the pathophysiology of both PCOS and endometriosis. Targeting EV-mediated communication may open avenues for novel diagnostic and therapeutic approaches for these common gynecological disorders. More research is essential to unravel the mechanisms underlying EV involvement in folliculogenesis and its dysregulation in PCOS and endometriosis, ultimately leading to more effective and personalized interventions.

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Microneedle systems: cell, exosome, and nucleic acid based strategies

Abstract: Cells, exosomes, and nucleic acids play crucial roles in biomedical engineering, holding substantial clinical potential. However, their utility is often hindered by various drawbacks, including cellular immunogenicity, and instability of...

Cited by 3 publications

References 86 publications

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices

Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review

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