Multifunctional metal–organic frameworks-based biocatalytic platforms: recent developments and future prospects

Bilal, Muhammad; Adeel, Muhammad; Rasheed, Tahir; Iqbal, Hafiz M.N.

doi:10.1016/j.jmrt.2018.12.001

Cited by 101 publications

(45 citation statements)

References 95 publications

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“…These multi-functional sites further enhance interest in MOFs materials. Presently, four well-established methodologies are being used to develop functional sites in the MOF architecture such as organic ligands, the introduction of various guest components, both metal clusters and organic ligands, and constructing an array with functional sites which include guest molecules with another functional site [10][11][12][13][14]. These approaches make MOFs an optimum platform to design and manufacture functionally fabricated materials.…”

Section: Introductionmentioning

confidence: 99%

“…These approaches make MOFs an optimum platform to design and manufacture functionally fabricated materials. Figure 1 illustrates a schematic representation of various synthesis routes, considerable properties, and applications of MOFs [14]. From the catalysis perspectives, MOFs materials present fascinating advantages, as catalysts, over others in practice, and conventional catalytic materials, such as clays, zeolites, or mesoporous silica.…”

Section: Introductionmentioning

confidence: 99%

“…From the catalysis perspectives, MOFs materials present fascinating advantages, as catalysts, over others in practice, and conventional catalytic materials, such as clays, zeolites, or mesoporous silica. Among several notable multifunctional catalytic potentialities of MOFs, some can be highlighted: (1) the structural tunability, (2) diversity of MOF components, i.e., linkers, nodes, and pores, (3) various catalytic sites in a single MOF, (4) the highly tunable and uniform porous environments, (5) recognition and transport of products and substrates, (6) the well-defined and adjustable framework allows to comprehend the catalytic mechanism, (7) structure-function relationship at the molecular level, and (8) rigorous catalysis in a wide array of catalytic reactions [6,13,14].…”

Section: Introductionmentioning

confidence: 99%

“…A schematic overview of MOF synthesis, properties, and applications. Reprinted from Bilal et al[14] an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/). Copyright (2018) Brazilian Metallurgical, Materials and Mining Association.…”

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confidence: 99%

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Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

et al. 2020

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Metal-organic frameworks (MOFs) are a fascinating class of porous crystalline materials constructed by organic ligands and inorganic connectors. Owing to their noteworthy catalytic chemistry, and matching or compatible coordination with numerous materials, MOFs offer potential applications in diverse fields such as catalysis, proton conduction, gas storage, drug delivery, sensing, separation and other related biotechnological and biomedical applications. Moreover, their designable structural topologies, high surface area, ultrahigh porosity, and tunable functionalities all make them excellent materials of interests for nanoscale applications. Herein, an effort has been to summarize the current advancement of MOF-based materials (i.e., pristine MOFs, MOF derivatives, or MOF composites) for electrocatalysis, photocatalysis, and biocatalysis. In the first part, we discussed the electrocatalytic behavior of various MOFs, such as oxidation and reduction candidates for different types of chemical reactions. The second section emphasizes on the photocatalytic performance of various MOFs as potential candidates for light-driven reactions, including photocatalytic degradation of various contaminants, CO2 reduction, and water splitting. Applications of MOFs-based porous materials in the biomedical sector, such as drug delivery, sensing and biosensing, antibacterial agents, and biomimetic systems for various biological species is discussed in the third part. Finally, the concluding points, challenges, and future prospects regarding MOFs or MOF-based materials for catalytic applications are also highlighted.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

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“…The microenvironment in nanostructures plays an important role in enzymatic activity [27][28][29]. The microenvironmental modification of nanocarriers can enhance the enzymatic catalytic activity and catalytic performance characteristics, which has received more and more attention [30][31][32][33]. ε-Poly-L-lysine (EPL)-modified mesoporous titanium dioxide (M-TiO 2 ) with negative charges for immobilized enzymes displayed strong storage stability, thermal stability, and good reusability [28].…”

Section: Introductionmentioning

confidence: 99%

Alkaline Modification of a Metal–Enzyme–Surfactant Nanocomposite to Enhance the Production of L-α-glycerylphosphorylcholine

Cao

et al. 2019

Catalysts

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Microenvironment modification within nanoconfinement can maximize the catalytic activity of enzymes. Phospholipase A1 (PLA1) has been used as the biocatalyst to produce high value L-α-glycerylphosphorylcholine (L-α-GPC) through hydrolysis of phosphatidylcholine (PC). We successfully developed a simple co-precipitation method to encapsulate PLA1 in a metal–surfactant nanocomposite (MSNC), then modified it using alkalescent 2-Methylimidazole (2-Melm) to promote catalytic efficiency in biphasic systems. The generated 2-Melm@PLA1/MSNC showed higher catalytic activity than PLA1/MSNC and free PLA1. Scanning electron microscopy and transmission electron microscopy showed a typical spherical structure of 2-Melm@PLA1/MSNC at about 50 nm, which was smaller than that of 2-Melm@MSNC. Energy disperse spectroscopy, N2 adsorption isotherms, Fourier transform infrared spectrum, and high-resolution X-ray photoelectron spectroscopy proved that 2-Melm successfully modified PLA1/MSNC. The generated 2-Melm@PLA1/MSNC showed a high catalytic rate per unit enzyme mass of 1.58 μmol mg-1 min-1 for the formation of L-α-GPC. The 2-Melm@PLA1/MSNC also showed high thermal stability, pH stability, and reusability in a water–hexane biphasic system. The integration of alkaline and amphiphilic properties of a nanocomposite encapsulating PLA1 resulted in highly efficient sequenced reactions of acyl migration and enzymatic hydrolysis at the interface of a biphasic system, which cannot be achieved by free enzyme.

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Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Liang

2020

Adv Funct Materials

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Biocatalytic metal-organic framework (MOF) composites, synthesized by interfacing MOFs with biocatalytic components, possess the unprecedented synergetic properties that is hard to achieve by the conventional strategies, represents one of the next-generation composite materials for diverse biotechnological applications. Until now , research on the applications of biocatalytic MOFs is still in its preliminary stage, with a wide variety of studies being focusing on the bioprotection role of MOFs. However, their diversity of building units, molecular-scale tunability, modular synthetic routes, and more detailed understanding of the heterogeneous MOF-biointerface could even lead to completely new applications and potentials beyond our current imagination. The most recent rapid advanced progress in biocatalytic MOFs present ground-breaking applications in smart and tunable biocatalysis, precision nanomedicine, vaccine and gene delivery, biosensing and nano-biohybrids. Herein, the general and advanced synthesis strategies for improving the materials properties of biocatalytic MOFs, from tuning biocatalytic activity to framework stability to synergistic properties with other materials, are summarized. Then, the latest state-of-the-art applications of the biocatalytic MOF systems and recent advanced developments that are shaping this emerging field are surveyed. Finally, to define promising research directions, a critical evaluation and future prospects for the potential applications of biocatalytic MOFs are provided.

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Multifunctional metal–organic frameworks-based biocatalytic platforms: recent developments and future prospects

Cited by 101 publications

References 95 publications

Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Alkaline Modification of a Metal–Enzyme–Surfactant Nanocomposite to Enhance the Production of L-α-glycerylphosphorylcholine

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

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