Multifunctional Magnesium Organic Framework-Based Microneedle Patch for Accelerating Diabetic Wound Healing

Abstract

Diabetic wound healing is one of the major challenges in the biomedical fields. The conventional single drug treatments have unsatisfactory efficacy, and the drug delivery effectiveness is restricted by the penetration depth. Herein, we develop a magnesium organic framework-based microneedle patch (denoted as MN-MOF-GO-Ag) that can realize transdermal delivery and combination therapy for diabetic wound healing. Multifunctional magnesium organic frameworks (Mg-MOFs) are mixed with poly­(γ-glutamic acid) (γ-PGA) hydrogel and loaded into the tips of MN-MOF-GO-Ag, which slowly releases Mg2+ and gallic acid in the deep layer of the dermis. The released Mg2+ induces cell migration and endothelial tubulogenesis, while gallic acid, a reactive oxygen species-scavenger, promotes antioxidation. Besides, the backing layer of MN-MOF-GO-Ag is made of γ-PGA hydrogel and graphene oxide-silver nanocomposites (GO-Ag) which further enables excellent antibacterial effects for accelerating wound healing. The therapeutic effects of MN-MOF-GO-Ag on wound healing are demonstrated with the full-thickness cutaneous wounds of a diabetic mouse model. The significant improvement of wound healing is achieved for mice treated with MN-MOF-GO-Ag.

Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration

“…The successful synthesis of Mg-GA MOF was further demonstrated by X-ray diffraction (XRD) and the routine XRD pattern were shown in Fig. 2 B, which was consistent with previous reports [ 42 , 43 ]. The crystallinity of Mg-GA MOF was calculated to be 6.96 (0.07)% ( Fig.…”

Microneedle Patches Integrated with Biomineralized Melanin Nanoparticles for Simultaneous Skin Tumor Photothermal Therapy and Wound Healing

“…Recently, the application of microneedle technology is expanded to wound management for its firm anchoring to tissues in a minimally invasive manner. [49,50] To demonstrate the advantages of MN patch in the treatment of open wound, CINP@SiO 2 -HA hydrogel dressing was utilized as a control. The needle tips of MN patch can pierce into the subcutaneous tissue like a wedge, thus MN patch could firmly contact with the wound tissue, while hydrogel dressing loosely adhered to the wound and displayed obvious gaps (Figure S11, Supporting Information).…”

A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

“…1 , PDA was bound to the PAM network through the interactions between the amino as well as catechol groups in PDA and the amino groups in PAM. Magnesium ions (Mg 2+ ) was incorporated in the hydrogel for the promoting effects on cell proliferation, differentiation, and tissue regeneration [ [24] , [25] , [26] ]. The hybrid crosslinks of covalent bonds and reversible non-covalent bonds in PDA-PAM/Mg 2+ hydrogel conferred favorable self-healing and adhesive capability.…”