Multifunctional hydroxyapatite nanoparticles for drug delivery and multimodal molecular imaging

Syamchand, Sasidharanpillai S.; George, Sony

doi:10.1007/s00604-015-1504-x

Cited by 108 publications

(40 citation statements)

References 159 publications

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“…Hydroxyapatite (HAp) is a well-known biomaterial that has been used as bone tissue because of its excellent bioactivity. [98] Our group fabricated AIEgen (4,4′-(1,2-diphenylethene-1,2-diyl)bis(4,1-phenylene))bis-(methylene) diphosphonic acid (PATPE) (Figure 7a) into HAp to construct AIEgen-functionalized hollow mesoporous nanocapsules with the assistance of surfactant cetyltrimethylammonium bromide (CTAB) (MHAp-FL) (Figure 7b). [99] The PATPE links with HAp by P-O-Ca covalent bonding, which can limit the rotation of molecules, leading to the resulting materials emit strong blue fluorescence at 487 nm (Figure 7c).…”

Section: Drug Deliverymentioning

confidence: 99%

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

2016

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Inorganic materials functionalized with organic fluorescent molecules combine advantages of them both, showing potential applications in biomedicine, chemosensors, light-emitting, and so on. However, when more traditional organic dyes are doped into the inorganic materials, the emission of resulting hybrid materials may be quenched, which is not conducive to the efficiency and sensitivity of detection. In contrast to the aggregation-caused quenching (ACQ) system, the aggregation-induced emission luminogens (AIEgens) with high solid quantum efficiency, offer new potential for developing highly efficient inorganic-organic hybrid luminescent materials. So far, many AIEgens have been incorporated into inorganic materials through either physical doping caused by aggregation induced emission (AIE) or chemical bonding (e.g., covalent bonding, ionic bonding, and coordination bonding) caused by bonding induced emission (BIE) strategy. The hybrid materials exhibit excellent photoactive properties due to the intramolecular motion of AIEgens is restricted by inorganic matrix. Recent advances in the fabrication of AIEgens-functionalized inorganic-organic hybrid materials and their applications in biomedicine, chemical sensing, and solid-state light emitting are presented.

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Section: Drug Deliverymentioning

confidence: 99%

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

2016

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“…Without the presence of the material fluorescence (Figure f,h), it is difficult to determine the precise location of the HA material within bone tissue and to determine its relative interrelation with the bone tissue if only observed from Figure e,g. Previously developed superparamagnetic, fluorescent, or luminomagnetic HA‐based materials have been used mainly for the multimodal imaging of cells and molecules and for drug delivery, rather than for long‐term tracking of implanted bone repair materials. The novel HYH‐Fe material created in this study will be of use for hospitals and clinicians for the long‐term or lifelong monitoring of the effects of bone repair in patients, as well as for the synergistic promotion of osteogenesis when combined with SMF.…”

Section: Resultsmentioning

confidence: 99%

Synergistic Effects of Novel Superparamagnetic/Upconversion HA Material and Ti/Magnet Implant on Biological Performance and Long‐Term In Vivo Tracking

Zou

Man

et al. 2019

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To solve the clinical challenges presented by the long‐term tracking of implanted hydroxyapatite (HA) bone repair material and to investigate the synergistic effects of superparamagnetic HA and a static magnetic field (SMF) on the promotion of osteogenesis, herein a new type of superparamagnetic/upconversion‐generating HA material (HYH‐Fe) is developed via a two‐step doping method, as well as a specially‐designed titanium implant with a built‐in magnet to provide a local static magnetic field in vivo. The results show that the prepared HYH‐Fe material maintains the crystal structure of HA and exhibits good cytocompatibility. The combined use of the superparamagnetic HYH‐Fe material and SMF can effectively and synergistically promote osteogenesis/osteointegration surrounding the Ti implants. In addition, the HYH‐Fe material exhibits distinct advantages in terms of both long‐term fluorescence tracking and microcomputed tomography (micro‐CT) tracking. The new material and tracking strategy in this study provide scientific feasibility and will have important clinical value for long‐term tracking and evaluation of implanted materials and the bone repair effect.

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“…In Apart from molecular targeting strategies, CaP NPs are also interesting materials for alternative targeting approaches such as magnetic driving. In this respect, several recent studies reported on the obtainment of magnetic CaP NPs by doping with iron ions [160,165,176,[254][255][256][257][258] or by the encapsulation of iron oxide phases [259][260][261][262][263][264]. Magnetic CaPs can be remotely controlled in the organism by employing external magnetic fields [28,254,265,266].…”

Section: Future Approaches and Perspectivesmentioning

confidence: 99%

Calcium phosphate-based nanosystems for advanced targeted nanomedicine

Esposti

Carella

Adamiano

et al. 2018

Drug Development and Industrial Pharmacy

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Synthetic calcium phosphates (CaPs) are the most widely accepted bioceramics for the repair and reconstruction of bone tissue defects. The recent advancements in materials science have prompted a rapid progress in the preparation of CaPs with nanometric dimensions, tailored surface characteristics, and colloidal stability opening new perspectives in their use for applications not strictly related to bone. In particular, the employment of CaPs nanoparticles as carriers of therapeutic and imaging agents has recently raised great interest in nanomedicine. CaPs nanoparticles, as well as other kinds of nanoparticles, can be engineered to specifically target the site of the disease (cells or organs), thus minimizing their dispersion in the body and undesired organism-nanoparticles interactions. The most promising and efficient approach to improve their specificity is the 'active targeting', where nanoparticles are conjugated with a targeting moiety able to recognize and bind with high efficacy and selectivity to receptors that are highly expressed only in the therapeutic site. The aim of this review is to give an overview on advanced targeted nanomedicine with a focus on the most recent reports on CaP nanoparticles-based systems, specifically designed for the active targeting. The distinctive characteristics of CaP nanoparticles with respect to the other kinds of nanomaterials used in nanomedicine are also discussed.

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Multifunctional hydroxyapatite nanoparticles for drug delivery and multimodal molecular imaging

Cited by 108 publications

References 159 publications

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

Synergistic Effects of Novel Superparamagnetic/Upconversion HA Material and Ti/Magnet Implant on Biological Performance and Long‐Term In Vivo Tracking

Calcium phosphate-based nanosystems for advanced targeted nanomedicine

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