Diabetic foot ulcers (DFUs) represent a common and challenging
wound in clinical practice. The treatment of DFUs is hindered by various
factors, including increased inflammation, impaired cell migration
and proliferation, and abnormal blood vessel formation due to oxidative
stress in a hyperglycemic environment. To enhance the therapeutic
outcomes of DFUs, we have developed an intelligent hydrogel through
modification with catechol and phenylboronic ester grafts. This hydrogel
exhibits high glucose responsiveness and adhesiveness. The experiments
have demonstrated that the dissociation of boronic ester bonds enables
dynamic regulation of the diabetic microenvironment, allowing controlled
release of antidiabetic drugs, thereby effectively promoting wound
healing. The hydrogel possesses excellent tissue adhesion, conforming
seamlessly to the skin and offering effective protection against external
stresses during the tissue repair process in diabetic wounds. Research
findings indicate that the hydrogel efficiently scavenges free radicals,
ameliorating the oxidative stress at the wound site. Simultaneously,
it facilitates cell migration, propelling angiogenesis, improving
the healing process of diabetic wounds, and enhancing collagen deposition
and tissue remodeling. This adhesive and glucose-responsive antioxidant
hydrogel holds immense potential in the treatment of DFUs.