Multifunctional Gold Nanorods with Ultrahigh Stability and Tunability for In Vivo Fluorescence Imaging, SERS Detection, and Photodynamic Therapy

Zhang, Yuan; Qian, Jun; Wang, Dan; Wang, Yalun; He, Sailing

doi:10.1002/ange.201207909

Cited by 46 publications

(36 citation statements)

References 28 publications

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“…More recently, an increasing amount of research has been conducted in evaluating and improving photosensitizers to enhance the efficacy of PDT in various cancer types (7)(8)(9)(10)(11)(12)(13)(14). Our particular photosensitizer of interest is indocyanine green (ICG), which is a water-soluble, anionic tricarbocyanine dye commonly used in numerous medical imaging and diagnostic applications (15).…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

2014

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Section: Introductionmentioning

confidence: 99%

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

2014

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“…We concisely discussed here only theranostics study, where SERS would be one key component of tumor detection. In 2013, Zhang et al demonstrated simultaneous detection of tumors and therapeutic study by multifunctional GNRs [64]. In this study, an in vivo tumor target was studied based on passive uptake through 'enhanced permeability and retention' of GNRs in the tumor.…”

Section: Multifunctional Sers Nanotags For Theranosticmentioning

confidence: 98%

Biocompatible Surface-Enhanced Raman Scattering Nanotags for In Vivo Cancer Detection

et al. 2014

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The advancement of surface-enhanced Raman scattering (SERS) is significantly increasing as an ultra-sensitive sensing technology in biomedical research. In this review, we focus on the most recent developments of biocompatible nanoprobes for cancer research. First, we discuss coating approaches to enhance the biocompatibility of SERS substrate and Raman reporters. Furthermore, interesting ligands such as antibodies, aptamers and polypeptides are attached to the surface of nanotags for targeting the cancerous cells in vitro. The unique multiplexing capabilities of the SERS technique have been applied for simultaneous multiple target recognition. Finally, these noninvasive, ultrasensitive tools are mostly highlighted for in vivo tumor detection. Potential application of SERS nanotags in therapeutic study and the possibility of SERS nanotags in biomedical applications are outlined briefly in this review.

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“…5,6 Gold nanoparticles (e.g., nanorods, nanoshells, nanocages, and nanostars) have received great attention as nanotheranostic agents due to their properties including strong localized surface plasmon resonance, in vivo stability, biocompatibility, and facile surface modification via strong thiol---gold chemical bonding. 7,8,9,10,11,12,13,14,15,16,17,18 They have been designed to have strong surface plasmon resonance in the near---infrared (NIR) region, which is considered to be the tissue optical window for biomedical imaging and therapy due to the low optical attenuation in this spectral range (700---900 nm). 19 Those gold nanoparticles have been used for surface---enhanced Raman spectroscopy (SERS), multiphoton microscopy, photothermal therapy (PTT), photodynamic therapy (PDT), drug delivery and other applications.…”

Section: Nanotheranosticsmentioning

confidence: 99%

Multifunctional Gold Nanostars for Cancer Theranostics

Liu¹

2018

Springer Theses

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The prevalence of cancer has increasingly become a significant threat to human health and as such, there exists a strong need for developing novel methods for early detection and effective therapy. Nanotheranostics, a combination of diagnostic and therapeutic functions into a single nanoplatform, has great potential to be used for cancer management by allowing detection, real-time tracking, image-guided therapy and therapeutic response monitoring. Gold nanostars (GNS) with tip-enhanced plasmonics have become one of the most promising platforms for cancer nanotheranostics. This work is aimed at addressing the challenges of sensitive cancer detection, metastasis treatment and recurrence prevention by combining state-of-the-art nanotechnology, molecular imaging and immunotherapy. A multifunctional GNS nanoprobe is developed with capabilities ranging from non-invasive, multi-modality cancer detection using positron emission tomography (PET), magnetic resonance imaging (MRI) and X-ray computed tomography (CT), to intraoperative tumor margin delineation with surface enhanced Raman spectroscopy (SERS) and high-resolution nanoprobe tracking with two-photon photoluminescence (TPL), as well as cancer treatment with photoimmunotherapy. The GNS nanoprobe with PET scans is particularly exceptional in detecting brain malignancies as small as 0.5 mm. To the best of our knowledge, the developed GNS nanoprobe for PET imaging provides the most v sensitive means of brain tumor detection reported so far. In addition, the GNS nanoprobe exhibits superior performance as photon-to-heat transducer and can be used for specific photothermal therapy (PTT). More importantly, GNS-mediated PTT combined with checkpoint inhibitor immunotherapy has been found to trigger a memorized immunoresponse to treat cancer metastasis and prevent recurrence in mouse model studies. Furthermore, a 6-month in vivo toxicity study including body weight monitoring, blood chemistry test and histopathology examination demonstrate GNS nanoparticles' biocompatibility. Therefore, the multifunctional GNS nanoprobe exhibits superior cancer detection and treatment capabilities and has great promise for future clinical translation in cancer management.

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Multifunctional Gold Nanorods with Ultrahigh Stability and Tunability for In Vivo Fluorescence Imaging, SERS Detection, and Photodynamic Therapy

Cited by 46 publications

References 28 publications

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

Biocompatible Surface-Enhanced Raman Scattering Nanotags for In Vivo Cancer Detection

Multifunctional Gold Nanostars for Cancer Theranostics

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