Multifunctional Fe₅C₂ Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography‐Guided Photothermal Therapy

Abstract

Fe5 C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell. By conjugating a new class of affinity proteins (ZHER2:342), they can target to tumor cells with low cytotoxicity, and kill them through laser irritation. It is also possible to ablate tumors under guidance by MRI and PTT without noticeable side effects.

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

“…69 This technique is employed in this study to confirm the radiosensitization properties of the Bi 2 Se 3 -CS-RGD NSs. The T 2 -weighted MR images of HeLa tumors using an EG 1.5 T clinical MR scanner equipped with a small animal imaging (Figure 11c) compared with the control group.…”

Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

“…Given its many key merits, PA imaging as one of the fastest‐growing molecular imaging technologies has been proved effective in tumor detection and molecular characterization 83. In addition, consistent with the principle for photothermal therapy (PTT) that requires efficient conversion of photon energy into heat, PA imaging is ideal to pair with PTT to develop optical theranostics 84. However, the endogenous contrast is limited to hemoglobin, lipids, and melanin.…”

The effect of neighbor distance of magnetic nanoparticle clusters on magnetic resonance relaxation properties

“…Superparamagnetic iron oxide (SPIO) nanoparticles are effective magnetic resonance imaging (MRI) contrast agents for molecular and cellular imaging including tumor diagnosis, gene expression, cellular trafficking and angiogenesis imaging [1][2][3][4][5][6]. They are strong enhancers of proton relaxation with superior MR transverse relaxation (T 2 ) shortening effects, and can be used at a much lower concentration than paramagnetic agents [7][8][9].…”

“…For this reason, considerable interests have focused on the properties of SPIO nanoparticles including their size, morphology, dopant, coating thickness and degree of SPIO nanocrystal clustering to obtain high-performance T 2 MRI contrast agents [10,11]. Of which, the size of the nanoparticles is one of the key parameters that the T 2 -weighted MR signal intensity decreases with increasing core size [12], but particles with inorganic core diameters beyond 20 nm are usually no longer superparamagnetic at room temperature [6]. Incorporation of a magnetic dopant, such as Mn 2?…”