Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration

Zhuang, Jingwen; Hang, Ruiyue; Sun, Ruoyue; Ding, Yanshu; Yao, Xin; Hang, Ruiqiang; Sun, Hui; Bai, Long

doi:10.3389/fchem.2022.984131

Cited by 8 publications

(5 citation statements)

References 74 publications

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“…8 Exosomes made from stem cells, for example, can be used in cell-free therapies and have advantages over using actual stem cells, including not inducing an immune response against them, lowering the risk of thromboembolism, and evaluation in line with pharmacological agents. 13,25,26 Exosomes can control and have an impact on cell death throughout the network repair process. Because SPM exosomes include proteins that can control M1/2 macrophage polarization, they are effective at enhancing the quality of tendon/ligament integration into bone.…”

Section: Discussionmentioning

confidence: 99%

Prospect of Exosome in Ligament Healing: A Systematical Review

Yanuar,

Agustina,

Budhiparama

et al. 2023

SCCAA

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Aim The relationship between ligaments and bone is a complex and heterogeneous junction involving bone, mineralized fibro cartilage, non-mineralized fibro cartilage and ligaments. Mesenchymal stem cells (MSC) can be used in vivo to control inflammation and aid in tissue repair, according to studies. This review focused on using exosomes as an alternative to MSC, as a cell-free therapy for modulating the remodelling process. Methods To conduct a systematic review of the literature, the phrases “exosome” and “ligament” or “tendon” and “extracellular vesicle” and “stem cells” were used as the search keywords in PubMed (MEDLINE), OVID, the Cochrane Library, and Science Direct. From the literature, 73 studies in all were found. Six studies were included in this systematic review after full-text evaluation. Results Six included studies covered a range of MSC types, isolation techniques, animal models, and interventions. Biomechanical results consistently indicated the beneficial impact of conditioned media, vesicles, and exosomes on treating tendons and ligaments. Noteworthy findings were the reduction of inflammation by iMSC-IEVs, chondrocyte protection by iPSC-EVs (extracellular vesicles generated by inflammation-primed adipose-derived stem cells), osteolysis treatment using DPSC-sEVs (small extracellular vesicles derived from dental pulp stem cells), and the contribution of exosome-educated macrophages to ligament injury wound healing. Conclusion Exosomes may serve as a cell-free therapeutic substitute for modulating the remodelling process, particularly in ligament healing.

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Section: Discussionmentioning

confidence: 99%

Prospect of Exosome in Ligament Healing: A Systematical Review

Yanuar,

Agustina,

Budhiparama

et al. 2023

SCCAA

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show abstract

“…Importantly, ncRNAs are present in exosomes that perform diverse functions including bone remodeling and bone-related disease [ 102 ]. BMSCs, osteoclasts, osteoblasts, lymphocytes, and macrophages secrete exosomes that regulate bone metabolism [ 103 ]. In bone metabolism, osteoblast differentiation is intercepted by exosomes secreted by osteoclasts [ 104 ].…”

Section: Exosomal Ncrnas and Bone Stem Cellsmentioning

confidence: 99%

Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders

Mishra

Kumar

Mishra

et al. 2023

Cells

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Stem cells’ self-renewal and multi-lineage differentiation are regulated by a complex network consisting of signaling factors, chromatin regulators, transcription factors, and non-coding RNAs (ncRNAs). Diverse role of ncRNAs in stem cell development and maintenance of bone homeostasis have been discovered recently. The ncRNAs, such as long non-coding RNAs, micro RNAs, circular RNAs, small interfering RNA, Piwi-interacting RNAs, etc., are not translated into proteins but act as essential epigenetic regulators in stem cells’ self-renewal and differentiation. Different signaling pathways are monitored efficiently by the differential expression of ncRNAs, which function as regulatory elements in determining the fate of stem cells. In addition, several species of ncRNAs could serve as potential molecular biomarkers in early diagnosis of bone diseases, including osteoporosis, osteoarthritis, and bone cancers, ultimately leading to the development of new therapeutic strategies. This review aims to explore the specific roles of ncRNAs and their effective molecular mechanisms in the growth and development of stem cells, and in the regulation of osteoblast and osteoclast activities. Furthermore, we focus on and explore the association of altered ncRNA expression with stem cells and bone turnover.

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“…Firstly, the efficacy of BMSCs in cell therapy depends on their ability to homing and long-term implantation into the injured site. The contribution of BMSCs in promoting new angiogenesis has been confirmed in animal models, but human clinical trials are not widely applied ( Zhuang et al, 2022 ). Previous reports showed that the number of CD34 + , C-kit + , or Flk-1 + cells, and the markers of endothelial lineage cells had increased in the wound healing process after the treatment of BMSCs conditioned medium ( Wu et al, 2007 ).…”

Section: Current Treatment Strategies For Iuamentioning

confidence: 99%

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels

Wu,

Lei,

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Intrauterine adhesion (IUA), also referred to as Asherman Syndrome (AS), results from uterine trauma in both pregnant and nonpregnant women. The IUA damages the endometrial bottom layer, causing partial or complete occlusion of the uterine cavity. This leads to irregular menstruation, infertility, or repeated abortions. Transcervical adhesion electroreception (TCRA) is frequently used to treat IUA, which greatly lowers the prevalence of adhesions and increases pregnancy rates. Although surgery aims to disentangle the adhesive tissue, it can exacerbate the development of IUA when the degree of adhesion is severer. Therefore, it is critical to develop innovative therapeutic approaches for the prevention of IUA. Endometrial fibrosis is the essence of IUA, and studies have found that the use of different types of mesenchymal stem cells (MSCs) can reduce the risk of endometrial fibrosis and increase the possibility of pregnancy. Recent research has suggested that exosomes derived from MSCs can overcome the limitations of MSCs, such as immunogenicity and tumorigenicity risks, thereby providing new directions for IUA treatment. Moreover, the hydrogel drug delivery system can significantly ameliorate the recurrence rate of adhesions and the intrauterine pregnancy rate of patients, and its potential mechanism in the treatment of IUA has also been studied. It has been shown that the combination of two or more therapeutic schemes has broader application prospects; therefore, this article reviews the pathophysiology of IUA and current treatment strategies, focusing on exosomes combined with hydrogels in the treatment of IUA. Although the use of exosomes and hydrogels has certain challenges in treating IUA, they still provide new promising directions in this field.

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Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration

Cited by 8 publications

References 74 publications

Prospect of Exosome in Ligament Healing: A Systematical Review

Prospect of Exosome in Ligament Healing: A Systematical Review

Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels

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