Multifunctional Dual Ionic-Covalent Membranes for Wound Healing

Li, Zhi; Chen, Sihao; Wu, Baiqing; Liu, Zulan; Cheng, Longdi; Bao, Yu; Ma, Yan; Chen, Lei; Tong, Xiaoling; Dai, Fangyin

doi:10.1021/acsbiomaterials.0c01512

Cited by 34 publications

(23 citation statements)

References 40 publications

(76 reference statements)

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“…In the early phase of wound healing, a race between cells and bacteria to the surface of the wound occurs 52 . Therefore, the antibacterial wound dressings play an important role in preventing wound infection, so that they can shorten the inflammatory stage and then promote wound healing 35,53 . In this study, the antibacterial effect of SF/PCL/MH membranes against E. coli, S. aureus , and C. albicans was investigated.…”

Section: Resultsmentioning

confidence: 99%

“…The antibacterial activity against E. coli, S. aureus , and C. albicans was evaluated as our previous study 35 . In short, the first step, E. coli , S. aureus , and C. albicans bacterial fluid (10 8 –10 9 CFU/ml) were diluted 10,000 times with liquid medium and PBS to obtain a standard bacterial solution (1.5 × 10 5 ~ 3.5 × 10 5 ).…”

Section: Methodsmentioning

confidence: 99%

“…The antibacterial activity against E. coli, S. aureus, and C. albicans was evaluated as our previous study. 35 In short, the first step, E. coli, S. aureus, and C. albicans bacterial fluid (10 8 -10 9 CFU/ml) were diluted 10,000 times with liquid medium and PBS to obtain a standard bacterial solution (1.5 Â 10 5 $ 3.5 Â 10 5 ). Then, the samples (0.1 g, sterilization), 0.03 mol/ml PBS and 1 ml standard bacterial solution were added into a 50 ml centrifuge tube and cultured at 37 C incubators for 18 h. The bacterial culture without samples was set as negative control and the bacterial culture with 25 μl gentamicin sulfate (GS) was set as positive control.…”

Section: Antibacterial Activity Of Sf/pcl/ Mh Membranesmentioning

confidence: 99%

“…52 Therefore, the antibacterial wound dressings play an important role in preventing wound infection, so that they can shorten the inflammatory stage and then promote wound healing. 35,53 In this study, the antibacterial effect of SF/PCL/MH membranes against E. coli, S. aureus, and C. albicans was investigated. As shown in Figure 7, after E. coli, S. aureus, and C. albicans were cultured together with different membranes for 18 h, the number of bacteria was remarkably reduced with the increase of MH content, indicating the enhanced antibacterial effect to E. coli, S. aureus, and C. albicans.…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Silk fibroin/polycaprolactone nanofibrous membranes loaded with natural Manuka honey for potential wound healing

Lan

Zhang

et al. 2021

J of Applied Polymer Sci

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Antibacterial wound dressing, an effective barrier between the wound and the foreign environment, has the ability to inhibit and even kill the bacteria around the wound so that it can accelerate the wound healing. However, the loaded antibacterial agents of antibiotics and metal ions on wound dressings caused the new problems of drug resistance and toxicity. To develop a novel wound dressing with the natural antibacterial property agent, here, natural Manuka honey (MH), silk fibroin (SF), and polycaprolactone (PCL) were mixed to prepare nanofibrous membranes by electrospinning. The SEM observation showed the good microscopic morphology of SF/PCL/MH nanofibrous membranes that the fibers were even and smooth. With the addition of MH, the membranes gained the accepted stress and the excellent flexibility to adapt to wound contour. In addition, their hydrophilic property was beneficial to cell adhesion and proliferation. Most importantly, SF/PCL/MH nanofibrous membranes exhibited excellent sustained release effect and antibacterial properties.The antibacterial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans reached 99.88%, 99.70%, and 98.95%, respectively when 75% natural antimicrobial agent MH was loaded. Moreover, SF/PCL/MH membranes showed good cytocompatibility. These results indicated the fabricated SF/PCL/MH nanofibrous membranes are a kind of novel dressing with good antimicrobial property.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Antibacterial Activity Of Sf/pcl/ Mh Membranesmentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

See 2 more Smart Citations

Silk fibroin/polycaprolactone nanofibrous membranes loaded with natural Manuka honey for potential wound healing

Lan

Zhang

et al. 2021

J of Applied Polymer Sci

Self Cite

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“…As the largest organ of the human body, the skin can be used to protect the human body from harm and the invasion of other microorganisms. 1 Bacterial infections caused by injures of the skin can delay wound healing and cause unpredictable harm. 2 However, wound dressing can be used to cover wounds or other injuries, and promote wound healing.…”

Section: Introductionmentioning

confidence: 99%

A conductive, antibacterial, and antifouling hydrogel based on zwitterion

Ding

Wang

et al. 2021

J of Applied Polymer Sci

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This paper proposes a cationic double-network hydrogel, which has good electrical conductivity, antibacterial properties, antiprotein adsorption, and mechanical properties. The cationic polymer formed a conductive path in the hydrogel network, so that the gel had good conductivity. With the increase of carboxybetaine ester, the conductivity gradually increases. As a sensor, hydrogel could respond quickly to strains such as stretching and bending. In addition, the hydrogel showed excellent antibacterial properties against Escherichia coli, the antibacterial rate can reach up to 99%. After hydrolysis, the hydrogel showed stable antiprotein adsorption performance. The tensile strength of the gel could reach 1.05 MPa, and the elongation at break was 474.31%. Therefore, this gel may be used for dressing and electronic skin. And the morphology of the hydrogel was characterized by FT-IR, X-ray diffraction, and SEM.

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Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Xiong

Qian

Lü

et al. 2023

Adv Funct Materials

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Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing physical and mental challenges for patients due to the lack of efficient curative therapy. Despite considerable advances in pharmacological and surgical approaches, clinical trials for DFU patients remain disappointing due to the local overactive and excessive inflammation. Immunomodulatory hydrogels has significant advantages to overcome the clinical challenge of DFUs therapy. Here, recent fabrication and regenerative advances in the utilization of functional hydrogels for altering the immune microenvironment of DFUs are comprehensively reviewed. The pathological features and the healing processes of DFUs, followed by summarizing the physicochemical properties essential for the design of regenerative hydrogels for immunomodulation in DFUs, are briefly introduced. Then, the potential immuno-therapeutic modalities of hydrogels and emerging trends used to treat DFUs via multitherapeutic approaches and enhanced efficacy and safety are discussed. Taken together, by linking the structural properties of hydrogels to their functions in DFU therapy with a particular focus on immunomodulatory stimuli, this review can promote further advances in designing advanced hydrogels for DFUs, resulting in improved diabetic wound repair through translation into clinical setting in the near future.

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Multifunctional Dual Ionic-Covalent Membranes for Wound Healing

Cited by 34 publications

References 40 publications

Silk fibroin/polycaprolactone nanofibrous membranes loaded with natural Manuka honey for potential wound healing

Silk fibroin/polycaprolactone nanofibrous membranes loaded with natural Manuka honey for potential wound healing

A conductive, antibacterial, and antifouling hydrogel based on zwitterion

Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

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