Multifrequency high precise subTHz-THz-IR spectroscopy for exhaled breath research

Вакс, В. Л.; Домрачева, Е. Г.; Приползин, С. И.; Chernyaeva, M. B.

doi:10.1117/12.2236686

Cited by 9 publications

(6 citation statements)

References 3 publications

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“…Для исследования легколетучих органических соединений (ЛОС) основным методом инструментального анализа компонентного состава выдыхаемого воздуха является масс-спектрометрия [1], а также, в меньшей степени, иные аналитические методы, например, инфракрасная или эмиссионная спектроскопия [2][3][4][5]. Широкое применение масс-спектрометрии для изучения газового состава выдоха обусловлено высокой чувствительностью и специфичностью данного метода анализа.…”

Section: инструментальные методы исследования волатома выдоха человекаunclassified

“…Вместе с тем методы исследования химического состава выдыхаемого воздуха для задач здравоохранения в настоящее время применяются недостаточно, несмотря на значительное число веществ [17, [29][30][31], а также заболеваний, для которых возможна оценка с использованием данного метода анализа [32][33][34][35]. Основными альтернативами методу масс-спектрометрической детекции являются технология электронного носа [5,[36][37][38], а также методы инфракрасной или эмиссионной спектроскопии [2][3][4]. Несмотря на то что приборы такого типа значительно дешевле масс-спектрометров, их низкая специфичность и чувствительность, а в случае технологии электронного носа также и низкая робастность затрудняют их широкое применение в научной и клинической практике.…”

Section: инструментальные методы исследования волатома выдоха человекаunclassified

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Volatomics in healthcare: technical basis and clinical application

Silantyev

Tuter

Bykova

et al. 2023

jour

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Volatilome is a collection of all volatile compounds, both organic and inorganic, the source of which is the object under study. Unlike the metabolome, which includes only compounds of endogenous origin, the concept of volatilome includes substances of both endogenous and exogenous origin. Exhaled air volatilome contains thousands of metabolites and volatile organic compounds (VOCs), which are formed both in the respiratory tract and in the systems of internal organs and tissues. The study of the chemical composition of human exhalation can provide clinically useful information about the state of human health, while the studies are non-invasive and safe for the patient. The instrumental methods used in the study of human volatilome make it possible to online examine large numbers of patients. All this contributes to a high interest on the part of the medical community in the study of human exhaled air volatilome and suggests that the methods of these research methods have a high potential for implementation in clinical practice.

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Section: инструментальные методы исследования волатома выдоха человекаunclassified

Volatomics in healthcare: technical basis and clinical application

Silantyev

Tuter

Bykova

et al. 2023

jour

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“…Normal human respiratory gas is a mixture of various gases containing hundreds of volatile organic compounds (VOCs) and large amounts of nitrogen (N 2 ), water (H 2 O) and carbon dioxide (CO 2 ). These gases derived from the blood by passive diffusion across the pulmonary alveolar membrane, and variation in the concentration of biomarker molecules is closely related to various metabolic diseases [1][2][3][4]. Breath gas analysis is intrinsically safe and noninvasive, opens a direct and unique window onto the blood composition, and offers a new approach for screening and early diagnosis of respiratory disease.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Lou

Jing

Wang

et al. 2019

Biomed. Opt. Express

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A spectroscopic detection system for the accurate monitoring of carbon dioxide (CO 2 ) in exhaled breath was realized by tunable diode laser absorption spectroscopy (TDLAS) in conjunction with a vertical-cavity surface-emitting laser (VCSEL) and a multipass cell with an effective optical path-length of 20 m. The VCSEL diode emitting light with an output power of 0.8 mW, covered the strong absorption line of CO 2 at 6330.82 cm −1 by drive-current tuning. The minimum detectable concentration of 0.769% for CO 2 detection was obtained, and a measurement precision of approximately 100 ppm was achieved with an integration time of 168 s. Real-time online measurements were carried out for the detection of CO 2 expirograms from healthy subjects, different concentrations were obtained in dead space and alveolar gas. The exhaled CO 2 increased significantly with the increasing physical activity, reaches its maximal value at the beginning of respiratory compensation and then decreased slightly until maximal exercise. The developed measurement system has a great potential to be applied in practice for the detection of pulmonary diseases associated with CO 2 retention.

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“…Although such sensor arrays offer portable and rapidly responding breath detection capabilities, specific biomarker identification and inter-device comparability remain problematic [40]. Vaks et al [41] and Shorter et al [42] selected a different approach by combining light sources emitting complementary wavelengths or wavelength regimes (i.e., subTHz, THz, IR, etc.) into a single setup, demonstrating, at least partially, online analysis [42].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Analytical Platform Based on Field-Asymmetric Ion Mobility Spectrometry, Infrared Sensing, and Luminescence-Based Oxygen Sensing for Exhaled Breath Analysis

Hagemann

Repp

Mizaikoff

2019

Sensors

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The reliable online analysis of volatile compounds in exhaled breath remains a challenge, as a plethora of molecules occur in different concentration ranges (i.e., ppt to %) and need to be detected against an extremely complex background matrix. Although this complexity is commonly addressed by hyphenating a specific analytical technique with appropriate preconcentration and/or preseparation strategies prior to detection, we herein propose the combination of three different detector types based on truly orthogonal measurement principles as an alternative solution: Field-asymmetric ion mobility spectrometry (FAIMS), Fourier-transform infrared (FTIR) spectroscopy-based sensors utilizing substrate-integrated hollow waveguides (iHWG), and luminescence sensing (LS). By carefully aligning the experimental needs and measurement protocols of all three methods, they were successfully integrated into a single compact analytical platform suitable for online measurements. The analytical performance of this prototype system was tested via artificial breath samples containing nitrogen (N2), oxygen (O2), carbon dioxide (CO2), and acetone as a model volatile organic compound (VOC) commonly present in breath. All three target analytes could be detected within their respectively breath-relevant concentration range, i.e., CO2 and O2 at 3-5 % and at ~19.6 %, respectively, while acetone could be detected with LOQs as low as 165-405 ppt. Orthogonality of the three methods operating in concert was clearly proven, which is essential to cover a possibly wide range of detectable analytes. Finally, the remaining challenges toward the implementation of the developed hybrid FAIMS-FTIR-LS system for exhaled breath analysis for metabolic studies in small animal intensive care units are discussed.

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Multifrequency high precise subTHz-THz-IR spectroscopy for exhaled breath research

Cited by 9 publications

References 3 publications

Volatomics in healthcare: technical basis and clinical application

Volatomics in healthcare: technical basis and clinical application

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Hybrid Analytical Platform Based on Field-Asymmetric Ion Mobility Spectrometry, Infrared Sensing, and Luminescence-Based Oxygen Sensing for Exhaled Breath Analysis

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