Multifocal synchronous osteosarcoma: The Scottish bone tumour registry experience

Jones, R. D.; Reid, Richard; Balakrishnan, G.; Barrett, Ann

doi:10.1002/mpo.2950210206

Cited by 26 publications

(23 citation statements)

References 16 publications

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“…3,23 Approximately 70-90% of tumors occur at the ends of long bones, particularly around the knee joint. 3,6,8,23 In the present case, the neoplasms that arose in the metaphyses of multiple long bones in the hind limbs were aggressive sarcomas that exhibited many lines of mesenchymal differentiation, making it difficult to determine the histogenetic classification of this tumor. Immunohistochemistry has been of limited use for the diagnosis of osteosarcoma in human medicine and is used primarily to exclude other neoplastic diseases.…”

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confidence: 69%

“…13,14,20,21,24 Primary osteosarcomas rarely cross joints or invade adjacent bones during early tumorogenesis, but as the tumor increases in size, both events occur more commonly. 8,21,23 Rare cases of multicentric osteosarcoma have been reported in humans and dogs. 3,8,10,14 An osteosarcoma that develops after successful treatment of another osteosarcoma lesion is termed a metachronous osteogenic sarcoma.…”

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confidence: 99%

“…8,21,23 Rare cases of multicentric osteosarcoma have been reported in humans and dogs. 3,8,10,14 An osteosarcoma that develops after successful treatment of another osteosarcoma lesion is termed a metachronous osteogenic sarcoma. 1,8,10 In human medicine, synchronous multicentric osteogenic neoplasms occur most commonly in children, usually under 15 years of age and carry a grave prognosis.…”

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confidence: 99%

“…1,6,8,10 They commonly arise in the metaphyses of long bones, especially the distal femur and proximal tibia. 1,8,14,23 In such cases, it may be difficult to determine whether the neoplasm is multifocal in origin or if the lesions are caused by metastatic disease. Symmetrical and synchronous involvement with distal metaphyseal lesions of identical radiographic character in long bones and sparing of the visceral organs are suggestive of multicentric origin.…”

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confidence: 99%

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Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog

Hoenerhoff¹,

Kiupel²,

Rosenstein³

et al. 2004

Vet Pathol

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Abstract. Apparently synchronous, aggressive, mixed mesenchymal tumors in the right tibia, right femur, left femur, and rib cage produced multiple microscopic metastases in the lungs and macroscopic metastases in the liver, kidney, and spleen in a 1.5-year-old, neutered male, mixed-breed dog. No primary soft tissue tumor mass was present. Microscopically, the neoplasm exhibited osteosarcomatous, chondrosarcomatous, liposarcomatous, leiomyosarcomatous, fibrosarcomatous, angiosarcomatous, and leukocytic differentiation and was diagnosed as a multipotential osteosarcoma with various mesenchymal differentiation. Immunohistochemically, the neoplasm was cytoplasmically immunoreactive for vimentin, osteonectin, osteocalcin, CD 18, CD 31, desmin, and muscle-specific actin. Oil Red O staining was positive within liposarcomatous areas. Skeletal metastases from a primary bone tumor are exceedingly rare in human and veterinary medicine. However, the history, clinical signs, location, microscopic and immunohistochemical features were similar to those described in aggressive, poorly differentiated osteosarcomas of children. In addition, the wide range of mesenchymal tissue differentiation of this neoplasm was unusual, and to the authors' knowledge, an osteosarcoma with this degree of multiple differentiation has not been previously reported in the dog.

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confidence: 69%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog

Hoenerhoff¹,

Kiupel²,

Rosenstein³

et al. 2004

Vet Pathol

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“…Synchronous multifocal osteosarcoma, a rare variant of osteosarcoma, is described as the simultaneous appearance of two or more tumors at any site in the peripheral or axial skeleton. 7,8,10,11,14,15,18,22,25) We present a case of synchronous multifocal osteosarcoma involving the skull presenting with intracerebral hemorrhage.…”

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confidence: 99%

Synchronous Multifocal Osteosarcoma Involving the Skull Presenting With Intracranial Hemorrhage -Case Report-

Sato

Hayashi

Yamamoto

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 40-year-old man presented with a rare case of synchronous multifocal osteosarcoma involving the skull associated with intracerebral hemorrhage, manifesting as sudden headache and left homonymous hemianopia. Computed tomography revealed a skull tumor in the right occipital bone and intracerebral hemorrhage in the right occipital lobe. Gross total resection of the skull tumor with hematoma was performed. The histological diagnosis was osteosarcoma. The tumor cells had invaded into the surrounding brain parenchyma, resulting in intracerebral hemorrhage.

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Metastatic osteosarcoma at diagnosis

Mialou

Philip

Kalifa

et al. 2005

Cancer

237

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Blends of polypropylene (PP) and thermoplastic elastomers (TPE), namely SBS (styrene‐butadiene‐styrene) and SEBS (styrene‐ethylene/1‐butene‐styrene) block copolymers, were prepared to evaluate the effectiveness of the TPE type as an impact modifier for PP and influence of the concentration of elastomer on the polymer properties. Polypropylene homopolymer (PP‐H) and ethylene–propylene random copolymer (PP‐R) were evaluated as the PP matrix. Results showed that TPEs had a nucleating effect that caused the PP crystallization temperature to increase, with SBS being more effective than SEBS. Microstructure characterization tests showed that in most cases PP/SEBS blends showed the smallest rubber droplets regardless of the matrix used. It was seen that SEBS is a more effective toughening agent for PP than SBS. At 0°C the Izod impact strength of the PP‐H/SEBS 30% b/w blend was twofold higher than the SBS strength, with the PP‐R/SEBS 30% b/w blend showing no break. A similar behavior on tensile properties and flexural modulus were observed in both PP/TPE blends. Yield stress and tensile strength decreased and elongation at break increased by expanding the dispersed elastomeric phase in the PP matrix. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 254–263, 2005

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Multifocal synchronous osteosarcoma: The Scottish bone tumour registry experience

Cited by 26 publications

References 16 publications

Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog

Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog

Synchronous Multifocal Osteosarcoma Involving the Skull Presenting With Intracranial Hemorrhage -Case Report-

Metastatic osteosarcoma at diagnosis

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