Multifocal primary amelanotic meningeal melanomas mimicking lymphoma: a case report and literature review

Abstract

Primary meningeal melanoma is a rare type of melanocytic cancer originating from the melanocytes of the leptomeninges. It commonly presents as a solitary mass, and multifocal amelanotic lesions were scarcely reported. Diagnosis of multifocal melanoma is particularly challenging, clinically and diagnostically, especially in the absence of cutaneous nevi and melanin pigment. Surgical biopsy result is the gold standard. In this case study, we present an uncommon case of multifocal primary amelanotic meningeal melanomas mimicking lymphomas in the skull base and near the Sylvian fissure, which serves to provide reference value to the clinical diagnosis. Physicians should be aware of the existence of this special type in the clinical work.

Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment

“…Unlike other brain tumors, primary CNS melanomas are affected by the paramagnetic effect of melanin. Tumors with more than 10% melanin content typically exhibit high signal intensity on T1‐weighted images and low signal intensity on T2‐weighted images, referred to as a “melanocyte” pattern, and vice versa (Arantes et al., 2011; Cao et al., 2020; Escott, 2001; Farrokh et al., 2001; Kang et al., 2006; Küsters‐Vandevelde, Küsters, et al., 2015; Rosenthal et al., 2003c; Roser et al., 2004; Szathmari et al., 2016; Tosaka et al., 2001; Varela‐Poblete et al., 2022). Anaplastic or hypopigmented melanomas show a low or equal signal on T1‐weighted images and a moderately high signal on T2‐weighted images.…”

Two New Prenylated Glycine Derivatives from the Marine‐Derived Fungus Fusarium sp. TW56‐10

“…The genus, Fusarium , one of the most bioactive compound producers, was first described and defined as endophytic fungus on Malamaceae plants, and more than 1000 species have been found in plants and marine sediments by now [3,4] . Large number of researches have proved that Fusarium owned potential ability to produce diverse secondary metabolites like polyketides, [5–7] alkaloids, [8–10] terpenoids, [11–14] peptides, [15,16] and steroids, [17,18] a majority of which possessed multiple bioactivity, such as cytotoxic, [13,17] antifungal, [15,17] anti‐inflammatory, [14] antiproliferative [16] and so on.…”