“…According to the recent World Health Organization (WHO) classification, melanomas are subdivided etiologically into those related to sun exposure and those that are not, with the former stratified according to cumulative solar damage (CSD) of the skin into low- and high-CSD melanomas [ 2 , 21 , 30 ]. Melanomas of which the etiology is predominantly unrelated to sun exposure include mucosal, acral, uveal and Spitzoid melanomas, melanomas arising in blue or congenital nevi, and rare melanomas arising in the CNS [ 7 , 21 , 25 , 27 , 31 , 32 , 33 , 34 , 35 ]. In this review, we will focus on melanomas related to sun exposure, including melanomas with low CSD, such as superficial spreading type and nodular melanomas, and with high CSD, such as the lentigo maligna type and desmoplastic melanomas [ 21 , 30 , 36 , 37 ].…”