Multifocal lumbar myxopapillary ependymoma presenting with drop metastasis: a case report and review of the literature

Tabor, Joanna K; Ryu, Brendan; Schneider, Daniel J.; Sciubba, Daniel M.; Narayana, Ashwatha; Zlochower, Avraham; Amico, Randy S D'

doi:10.1038/s41394-022-00513-x

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…Nine patients were managed by subtotal resection, and five received adjuvant radiotherapy. Despite receiving radiation, one case had local recurrence after subtotal resection and three years of follow-up; however, most patients reported symptomatic improvement with no tumor progression ( 6 , 9 - 18 ).…”

Section: Discussionmentioning

confidence: 97%

Myxopapillary Ependymoma–a Case Report of Rare Multicentric Subtype and Literature Review

AlMatrafi¹,

Aseeri²,

Alqahtani³

et al. 2023

Med Arch

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Background: Myxopapillary ependymoma is a rare type of primary spinal tumor, it is distinctly a slow-growing tumor that originates in the conus medullaris, cauda equina, or film terminals and is rarely identified as a multicentric type. Myxopapillary ependymoma has a unique histological characteristic and is associated with a generally better prognosis. Objective: We present a case of a rare multicentric myxopapillary ependymoma. Case presentation: A 28-year-old male with 1-year history of low back pain and 3 months of radiating pain to left lower limb with perianal anesthesia. Magnetic resonance imaging (MRI) exhibited a large intradural intramedullary lesion from the level of the conus medullaris extending to the filum terminals at the level of T12 to L3 with smaller multiple enhancing lesions seen opposite to L4 and L5 level as well as within the exiting nerve roots, at the left side of L1/L2 and L2/L3 and right side of L3/L4 and L5/S1 level. The patient underwent surgical resection with significant improvement in symptoms and no tumor progression on follow up MRI scan. Conclusion: We hereby present a case of multicentric myxopapillary ependymoma with a literature review of the previous reported cases. We believe that our study will make a significant contribution to the literature and will be of interest to the readership regarding of the rarity of multicentric Myxopapillary ependymoma and it will help in decision making for the proper surgical Intervention on these kinds of cases.

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Section: Discussionmentioning

confidence: 97%

Myxopapillary Ependymoma–a Case Report of Rare Multicentric Subtype and Literature Review

AlMatrafi¹,

Aseeri²,

Alqahtani³

et al. 2023

Med Arch

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“…2 Local recurrence occurs commonly following surgical resection, even after decade-long quiescence, and long-term monitoring and care are recommended. 1,3 Treatment for MPE is not standardized. In general, it is thought that gross total resection is an optimal course of treatment; however, the efficacy of adjuvant therapy remains controversial.…”

Section: Introductionmentioning

confidence: 99%

“…5,[7][8][9] In addition, MPEs rarely metastasize outside of the cerebrospinal axis, and pediatric patients show higher rates of central nervous system dissemination and extramedullary presentation than adults. 1,[10][11][12] A few published cases that show MPEs spread outside the neuroaxis into other organ systems, most commonly to the lymphatic system. 13,14 Here we describe a case in which a primary spinal MPE metastasized to the pleura, lung parenchyma, and intravascular space and mimicked the presentation of pulmonary embolism.…”

Section: Introductionmentioning

confidence: 99%

“…Myxopapillary ependymomas (MPEs) are rare neoplastic tumors arising from ependymal glial cells of the spinal cord; incidence is 0.5 to 0.8 per 100,000 people/year. 1 MPEs are the most common tumor of the cauda equina region, and the average age of onset is in the third or fourth decade of life. 1 MPEs are considered benign; however, they were upgraded to Grade II neoplasms in the 2021 World Health Organization (WHO) classification of Tumors of the Central Nervous System.…”

Section: Introductionmentioning

confidence: 99%

“…1 MPEs are the most common tumor of the cauda equina region, and the average age of onset is in the third or fourth decade of life. 1 MPEs are considered benign; however, they were upgraded to Grade II neoplasms in the 2021 World Health Organization (WHO) classification of Tumors of the Central Nervous System. 2 Local recurrence occurs commonly following surgical resection, even after decade-long quiescence, and long-term monitoring and care are recommended.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Myxopapillary Ependymoma Metastasis Mimicking Pulmonary Embolism: An Illustrative Case

Fecker,

Maanum,

Shahin

et al. 2024

Asian J Neurosurg

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Myxopapillary ependymomas (MPEs) are rare spinal cord tumors with low rates of metastasis outside of the neuraxis. Gross total resection of MPEs can significantly improve progression-free survival; however, adjunctive treatment remains unstandardized. A 29-year-old female with a history of spina bifida occulta surgical correction and lower back pain presented with dyspnea and tachycardia. A large pulmonary artery mass was discovered consistent with pulmonary thromboembolism. It was subsequently determined to be an intravascular metastasis secondary to sacral MPE. Standardization of MPE treatment and clinical suspicion of spinal neoplasm in the setting of chronic back pain with undetermined origin are of value.

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Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients

Zhang

Wang

et al. 2023

Eur Spine J

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Multifocal lumbar myxopapillary ependymoma presenting with drop metastasis: a case report and review of the literature

Cited by 6 publications

References 31 publications

Myxopapillary Ependymoma–a Case Report of Rare Multicentric Subtype and Literature Review

Myxopapillary Ependymoma–a Case Report of Rare Multicentric Subtype and Literature Review

Myxopapillary Ependymoma Metastasis Mimicking Pulmonary Embolism: An Illustrative Case

Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients

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