Multifocal and Multicentric Tumors

Werra, Carlo De; Donzelli, Ivana; Perone, Mario; Micco, Rosa Di; Orabona, Gianclaudio

doi:10.1007/978-88-470-1095-6_9

Cited by 11 publications

(10 citation statements)

References 10 publications

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“…This is in line with the data showing a difference in histology, pathologic grade, and receptor status at a higher percentage in patients with differing Oncotype Dx than in patients with similar Oncotype Dx. The possibility exists that the multiple primaries are actually a single primary with extension that is not able to be seen either radiographically or pathologically 20–22. If this were the case, one would expect to see correlation between distance between tumors and similarity of Oncotype Dx score, which was not the case in our analysis.…”

Section: Discussionmentioning

confidence: 76%

“…The possibility exists that the multiple primaries are actually a single primary with extension that is not able to be seen either radiographically or pathologically. [20][21][22] If this were the case, one would expect to see correlation between distance between tumors and similarity of Oncotype Dx score, which was not the case in our analysis.…”

Section: Discussionmentioning

confidence: 81%

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Oncotype Dx Results in Multiple Primary Breast Cancers

Toole

Kidwell

Poznak

2014

Breast Cancer�(Auckl)

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PURPOSETo determine whether multiple primary breast cancers have similar genetic profiles, specifically Oncotype Dx Recurrence Scores, and whether obtaining Oncotype Dx on each primary breast cancer affects chemotherapy recommendations.METHODSA database of patients with hormone receptor-positive, lymph node-negative, breast cancer was created for those tumors that were sent for Oncotype Dx testing from the University of Michigan Health System from 1/24/2005 to 2/25/2013.Retrospective chart review abstracted details of tumor location, histopathology, distance between tumors, Oncotype Dx results, and chemotherapy recommendations.RESULTSSix hundred and sixty-six patients for whom Oncotype Dx testing was sent were identified, with 22 patients having multiple breast tumor specimens sent. Of the 22 patients who had multiple samples sent for analysis, chemotherapy recommendations were changed in 6 of 22 patients (27%) based on significant differences in Oncotype Dx Recurrence Scores. Qualitatively, there seems to be a greater difference in genetic profile in tumors appearing simultaneously on different breasts when compared to multiple tumors on the same breast. There was no association between distance between tumors and difference in Oncotype Dx scores for tumors on the same breast.CONCLUSIONSOncotype Dx testing on multiple primary breast cancers altered management in regards to chemotherapy recommendations and should be considered for multiple primary breast cancers.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 81%

Oncotype Dx Results in Multiple Primary Breast Cancers

Toole

Kidwell

Poznak

2014

Breast Cancer�(Auckl)

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“…Multifocal tumours originate from a unique cellular clone and grow multifocally within a single organ, whilst multicentric tumours do not exhibit a clonal relationship, with respect to their carcinogenesis, yet they can develop simultaneously in more than one organ (de Werra ). The mechanism has yet to be fully elucidated; however, when deciding appropriate treatment or surgery for tumours of paired organs it is particularly important to consider if bilateral disease represents metastasis or results from genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Bilateral leiomyoma in the testes of a horse

Stoll

Tucker

Witte

et al. 2014

Equine Veterinary Education

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Summary A 19‐year‐old Hackney pony was referred to a veterinary teaching hospital for further investigation of left‐sided scrotal enlargement. Both testes were normally positioned within the scrotum and there was no pain on palpation. Ultrasonography revealed multiple masses of soft tissue echogenicity, located adjacent to the testicular parenchyma. They were hyperechoic when compared to the testicular parenchyma and affected both testes. Surgical excision was performed by closed castration. Gross examination revealed firm, white, nodular masses of varying size on the surface of both testes. The cut surface of individual masses had a dense, whorling, fibrous and somewhat shiny appearance. The histopathological diagnosis was bilateral, multicentric, well differentiated leiomyoma of the tunica albuginea. The smooth muscle origin was confirmed by immunohistochemical staining with an anti‐human monoclonal antibody reactive to smooth muscle actin. This is the first report of a bilateral, multicentric, leiomyoma in the testes of a horse confirmed by histopathology and immunohistochemistry. This case highlights that neoplasia should be considered as a differential for bilateral testicular enlargement.

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“…Metastasis in the present case is unlikely given absence of lymphovascular invasion in tissue sections examined and in the lungs. Multifocality and multicentricity are two somewhat confusing concepts in tumor development [ 7 ]. While multifocal tumors (typically due to local/regional metastasis) originate from a unique cellular clone and grow multifocally in a single organ, multicentric tumors develop simultaneously in more than one organ but without a clonal relationship with respect to their carcinogenesis [ 7 ].…”

mentioning

confidence: 99%

“…Multifocality and multicentricity are two somewhat confusing concepts in tumor development [ 7 ]. While multifocal tumors (typically due to local/regional metastasis) originate from a unique cellular clone and grow multifocally in a single organ, multicentric tumors develop simultaneously in more than one organ but without a clonal relationship with respect to their carcinogenesis [ 7 ]. Therapeutic response differences may exist between single (unicentric), multicentric and multiple (regional metastatic) tumors [ 7 ].…”

mentioning

confidence: 99%

Spontaneous multicentric soft tissue sarcoma in a captive African pygmy hedgehog (<i>Atelerix albiventris</i>): case report and literature review

Díaz‐Delgado

Pool

Hoppes

et al. 2017

The Journal of Veterinary Medical Science

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This report describes the clinical, macroscopic, histopathological and immunohistochemical features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum. Histologic, histochemical and immunohistochemical analyses supported a diagnosis of multicentric poorly differentiated spindle cell sarcoma with fibrosarcomatous, storiform and myxoid foci. The high incidence of neoplasia and cross similarities renders the African hedgehog a suitable species for comparative pathology studies.

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Multifocal and Multicentric Tumors

Cited by 11 publications

References 10 publications

Oncotype Dx Results in Multiple Primary Breast Cancers

Oncotype Dx Results in Multiple Primary Breast Cancers

Bilateral leiomyoma in the testes of a horse

Spontaneous multicentric soft tissue sarcoma in a captive African pygmy hedgehog (<i>Atelerix albiventris</i>): case report and literature review

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