Spontaneous multicentric soft tissue sarcoma in a captive African pygmy hedgehog (&lt;i&gt;Atelerix albiventris&lt;/i&gt;): case report and literature review

Díaz‐Delgado, Josué; Pool, Roy R.; Hoppes, Sharman; Cerezo, Argiñe; Quesada‐Canales, Óscar

doi:10.1292/jvms.17-0003

Cited by 15 publications

(9 citation statements)

References 38 publications

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“…The few retrospective studies that have been conducted on hedgehogs and their diseases have focused primarily on neoplastic disease or clinical diagnoses, and have been based on zoopathological research [ 5 , 8 , 14 , 21 ]. Many case reports have been published on captive African hedgehogs [ 3 , 12 , 15 , 17 , 20 ], most of which have focused on neoplastic disease. The aim of this study was to reveal the incidence of various diseases in captive African pygmy hedgehogs in Japan by using histopathological data.…”

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confidence: 99%

A retrospective study of disease incidence in African pygmy hedgehogs (Atelerix albiventris)

Okada¹,

Kondo

Sumi³

et al. 2018

The Journal of Veterinary Medical Science

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The African pygmy hedgehog (Atelerix albiventris) is becoming a popular pet in Japan. The aim of this study was to determine the incidence of various diseases in African pygmy hedgehogs. We histologically investigated 105 samples from 100 privately-owned pet African pygmy hedgehogs that were submitted to two laboratories (North Lab and Patho Labo) between 2012 and 2017. Tissues submitted for this study were taken from female reproductive organs (33 cases; 31.43%), skin (20 cases; 19.05%), and the oral mucosa (19 cases; 18.1%). The most common histological diagnoses included endometrial stromal nodules identified as benign uterine neoplasia (14 cases; 13.33%); endometrial polyps identified as non-neoplastic polyps (7 cases; 6.67%), gingival hyperplasia and chronic suppurative inflammation in the oral mucosa (11 cases; 10.48%), fibrosarcomas in the skin (8 cases; 7.62%), and mammary tumors (8 cases; 7.62%). In this study, lymphoma and oral squamous cell carcinoma were less common than in the previous reports. The present study revealed the disease prevalence in captive African pygmy hedghogs that were histopathologically examined.

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confidence: 99%

A retrospective study of disease incidence in African pygmy hedgehogs (Atelerix albiventris)

Okada¹,

Kondo

Sumi³

et al. 2018

The Journal of Veterinary Medical Science

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“…Hematopoietic tumors are the second most frequently occurring group of tumors, accounting for 11% of all tumors in four-toed hedgehogs [ 4 , 17 ]. Reports describing details of hematopoietic tumors in four-toed hedgehogs remain limited [ 2 , 8 ]. Some case reports have described clinical courses and pathological features of HS in four-toed hedgehogs, occurring at the subcutis, brain, mesenteric lymph node and intraabdominal mass of unknown origin including dissemination form [ 7 , 10 , 13 , 14 ].…”

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Primary localized histiocytic sarcoma of the lumbar vertebrae in a four-toed hedgehog (Atelerix albiventris)

Koizumi¹,

Okumura

Kondo

2020

J. Vet. Med. Sci.

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We describe a case of primary localized histiocytic sarcoma of the lumbar vertebrae in a four-toed hedgehog. The case showed aggressive osteolysis of lumbar vertebrae on radiography, and a soft-tissue mass effacing this region was noted, suggesting a neoplastic lesion. No metastatic lesions were apparent. Antemortem diagnosis was challenging, and necropsy was performed. Histopathological and immunohistochemical findings were consistent with localized histiocytic sarcoma. This report provides documentation of the clinical and pathologic features of an unusual form of histiocytic sarcoma localizing to lumbar vertebrae in a four-toed hedgehog.

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“…Anisokaryosis and anisocytosis were marked, and multinucleate giant cells were observed occasionally. Mitotic count was 50 per 2.37 mm 2 . Metastases of the neoplastic cells were recognized in the jejunum, ileum, liver, lung, spleen, and epicardium.…”

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confidence: 99%

“…1 Pet African pygmy hedgehogs frequently succumb to neoplasms at relatively young ages, and the CNS is often affected. 2,5,8,11,12 Therefore, neoplasms should be included in differential diagnoses of hedgehogs showing neurologic signs, and thorough examination of the CNS is important even in cases with apparent WHS-related lesions.…”

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Wobbly hedgehog syndrome with disseminated histiocytic sarcoma and lateral ventricular meningioma in an African pygmy hedgehog

et al. 2020

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An 8-mo-old male African pygmy hedgehog was anorectic and ataxic; physical examination revealed tetraparesis and a gangrenous left hindlimb. Analgesic and supportive care were administered, but the animal died 3 d after presentation. Postmortem examination revealed a histiocytic sarcoma in a mesenteric lymph node with metastasis to several organs, multifocal vacuolation in the cerebral and cerebellar white matter, and a meningioma in the left lateral ventricle. We diagnosed wobbly hedgehog syndrome (WHS) with disseminated histiocytic sarcoma and lateral ventricular meningioma. Ventricular meningioma, a rare neoplasm in veterinary and human patients, has not been reported previously in hedgehogs, to our knowledge. The neurologic signs in our case were probably caused by the WHS-related vacuolar lesions and are consistent with those of reported WHS cases. Duration of illness was shorter than is typical of WHS cases, which might be related to the disseminated histiocytic sarcoma. Clinical relevance of the lateral ventricular meningioma was not evident because the ventricular mass was localized and not invasive.

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Spontaneous multicentric soft tissue sarcoma in a captive African pygmy hedgehog (<i>Atelerix albiventris</i>): case report and literature review

Cited by 15 publications

References 38 publications

A retrospective study of disease incidence in African pygmy hedgehogs (<i>Atelerix albiventris</i>)

A retrospective study of disease incidence in African pygmy hedgehogs (<i>Atelerix albiventris</i>)

Primary localized histiocytic sarcoma of the lumbar vertebrae in a four-toed hedgehog (<i>Atelerix albiventris</i>)

Wobbly hedgehog syndrome with disseminated histiocytic sarcoma and lateral ventricular meningioma in an African pygmy hedgehog

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