Multifluid electrospinning for multi-drug delivery systems: pros and cons, challenges, and future directions

Tabakoglu, Sahranur; Kołbuk, Dorota

doi:10.1039/d2bm01513g

Cited by 52 publications

(31 citation statements)

References 234 publications

(288 reference statements)

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“…Pharmacologically active agents (also known as therapeutics or drugs) are used in medicine to control or stop the progression of disease [ 1 , 2 ]. Improved delivery methods and a better understanding of how drug administration affects safety and efficacy have been thoroughly discussed [ 3 , 4 ]. Drug delivery systems (DDSs) are technological systems that comprehensively regulate the distribution of drugs in the organism in terms of space, time, and dose [ 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Drug Delivery Systems: From Synthetic Polypeptide Vesicles to Outer Membrane Vesicles

Zhou

et al. 2023

Pharmaceutics

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Nanomedicine is a broad field that focuses on the development of nanocarriers to deliver specific drugs to targeted sites. A synthetic polypeptide is a kind of biomaterial composed of repeating amino acid units that are linked by peptide bonds. The multiplied amphiphilicity segment of the polypeptide could assemble to form polypeptide vesicles (PVs) under suitable conditions. Different from polypeptide vesicles, outer membrane vesicles (OMVs) are spherical buds of the outer membrane filled with periplasmic content, which commonly originate from Gram-negative bacteria. Owing to their biodegradability and excellent biocompatibility, both PVs and OMVs have been utilized as carriers in delivering drugs. In this review, we discuss the recent drug delivery research based on PVs and OMVs. These related topics are presented: (1) a brief introduction to the production methods for PVs and OMVs; (2) a thorough explanation of PV- and OMV-related applications in drug delivery including the vesicle design and biological assessment; (3) finally, we conclude with a discussion on perspectives and future challenges related to the drug delivery systems of PVs and OMVs.

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Section: Introductionmentioning

confidence: 99%

Bio-Inspired Drug Delivery Systems: From Synthetic Polypeptide Vesicles to Outer Membrane Vesicles

Zhou

et al. 2023

Pharmaceutics

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“…These properties can support cell synthesis of specific proteins and other biochemical and biological processes required for healthy tissue growth [28,83]. Therefore, electrospun fibers have become excellent candidates for various applications, such as catalysis [84], filtration [85], water treatment [86][87][88][89], biosensors [90][91][92], food packaging [93,94], cosmetics [95] and biomedicine [96][97][98][99][100][101].…”

Section: Introduction Of Electrospinning Technologymentioning

confidence: 99%

Recent Progress of Electrospun Herbal Medicine Nanofibers

et al. 2023

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Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability of the extract of raw herbs and bioactive compounds is poor because of their low water solubility. In order to overcome the solubility issues, electrospinning technology can offer a delivery alternative to resolve them. The electrospun fibers have the advantages of high specific surface area, high porosity, excellent mechanical strength and flexible structures. At the same time, various natural and synthetic polymer-bound fibers can mimic extracellular matrix applications in different medical fields. In this paper, the development of electrospinning technology and polymers used for incorporating herbal medicine into electrospun nanofibers are reviewed. Finally, the recent progress of the applications of these herbal medicine nanofibers in biomedical (drug delivery, wound dressing, tissue engineering) and food fields along with their future prospects is discussed.

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“…Thereby, the poor solubility of drugs pose a long-existing and difficult challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology ( Butreddy et al, 2021 ; Cai et al, 2021 ; Feng and Hao, 2021 ; Salerno and Netti, 2021 ; Sultana et al, 2021 ; Obeidat and Al-Natour, 2022 ). Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue ( Esim and Hascicek, 2021 ; Tabakoglu et al, 2022 ; Tang et al, 2022a ; Vega-Vásquez et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

Ge¹,

Ding

et al. 2023

Front. Bioeng. Biotechnol.

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The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology. Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue. In this study, a combination strategy of top-down process (electrospinning) and bottom-up (self-emulsifying) was demonstrated to be useful for enhancing the dissolution of a typical poorly water-soluble anticancer model drug (paclitaxel, PTX). With polyvinylpyrrolidone (PVP K90) as the filament-forming matrix and drug carrier, polyoxyethylene castor oil (PCO) as emulsifier, and triglyceride (TG) as oil phase, Both a single-fluid blending process and a coaxial process were utilized to prepare medicated nanofibers. Scanning electron microscope and transmission electron microscope (TEM) results clearly demonstrated the morphology and inner structures of the nanofibers. The lipid nanoparticles of emulsions after self-emulsification were also assessed through TEM. The encapsulation efficiency (EE) and in vitro dissolution tests demonstrated that the cores-shell nanofibers could provide a better self-emulsifying process int terms of a higher EE and a better drug sustained release profile. Meanwhile, an increase of sheath fluid rate could benefit an even better results, suggesting a clear process-property-performance relationship. The protocols reported here pave anew way for effective oral delivery of poorly water-soluble drug.

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Multifluid electrospinning for multi-drug delivery systems: pros and cons, challenges, and future directions

Abstract: The electrospinning method has been widely used to produce nano/micro fibers for a wide variety of applications. As a drug delivery system, electrospun fibers display many advantages such as controlled...

Cited by 52 publications

References 234 publications

Bio-Inspired Drug Delivery Systems: From Synthetic Polypeptide Vesicles to Outer Membrane Vesicles

Bio-Inspired Drug Delivery Systems: From Synthetic Polypeptide Vesicles to Outer Membrane Vesicles

Recent Progress of Electrospun Herbal Medicine Nanofibers

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

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