Multifarious anti-biofouling bioprosthetic heart valve materials with the formation of interpenetrating polymer network structures

Lei, Yang; Lan, Xiaorong; He, Zhoukun; Yin, Anlin; Jin, Wanyu; Hu, Quanjun; Wang, Yunbing

doi:10.1016/j.matdes.2021.109803

Cited by 13 publications

(9 citation statements)

References 86 publications

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“…The small openings after decellularization facilitated water and protein infiltration, thus water contact angle (WCA) decreased while protein adsorption increased, which is consistent with previous reports. [25,39] The coagulation experiments showed similar results: After constantly flowed whole blood through PP surfaces, more red blood cells and platelets were visualized on Glut-PP and dCell-PP while blood cells were barely adhered on hydrogel coating PPs (Fig- ure 3A,B). Platelet activation and adhesion on PPs were more ob-vious in platelet-rich plasma, but P/H-PP still exhibited excellent anticoagulation effect (Figure 3C,D).…”

Section: Hemocompatibility Of P/h-ppmentioning

confidence: 74%

“…[22] Biohybrid approaches can improve the biocompatibility of commercial BHV made from glutaraldehyde treated porcine pericardium, yet no effective strategy has been reported to conserve the biological properties of BHV after long-term fatigue test. [25] The combination of natural polymer and synthetic polymer in hydrogel can contribute complementary roles for better mechanical properties and biological properties. [26] In this study, we integrate DN hydrogel into decellularized porcine pericardium (dCell-PP) to shield the matrix with a reliable armor.…”

Section: Introductionmentioning

confidence: 99%

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Double‐Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves

Cheng

Liu

Qian

et al. 2022

Adv Healthcare Materials

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Heart valves have extraordinary fatigue resistance which beat ≈3 billion times in a lifetime. Bioprosthetic heart valves (BHVs) made from fixed heteroplasm that are incrementally used in heart valve replacement fail to sustain the expected durability due to thrombosis, poor endothelialization, inflammation, calcification, and especially mechanical damage induced biocompatibility change. No effective strategy has been reported to conserve the biological properties of BHV after long-term fatigue test. Here, a double-network tough hydrogel is introduced, which interpenetrate and anchor into the matrix of decellularized porcine pericardium (dCell-PP) to form robust and stable conformal coatings and reduce immunogenicity. The ionic crosslinked hyaluronic acid (HA) network mimics the glycocalyx on endothelium which improves antithrombosis and accelerates endothelialization; the chemical crosslinked hydrophilic polyacrylamide (PAAm) network further enhances antifouling properties and strengthens the shielding hydrogels and their interaction with dCell-PP. In vitro and rabbit ex vivo shunt assay demonstrate great hemocompatibility of polyacrylamide/HA hydrogel hybrid PP (P/H-PP). Cell experiments and rat subcutaneous implantation confirm satisfactory endothelialization, biocompatibility, and anticalcification properties. For hydrodynamic experiment, P/H-PP gains full mark at different flow conditions and sustains excellent biomechanical and biological properties after 200 000 000 cycles. P/H double-network hydrogel armoring dCell-PP is a promising progress to extend BHV durability for clinical implantation therapy.

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Section: Hemocompatibility Of P/h-ppmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Double‐Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves

Cheng

Liu

Qian

et al. 2022

Adv Healthcare Materials

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“…Reprinted with permission from Ref. (Lei et al, 2021). coauthors developed a stable superhydrophilic zwitterionic interface on PDMS by covalent silanization of sulfobetaine silane (SBSi) (Yeh et al, 2014).…”

Section: Iols and Cls In Ophthalmologymentioning

confidence: 99%

“…Hydrophilic polymers such as PAA are usually utilized to enhance the anti-biofouling actions of materials ( Zhang et al, 2021c ). Our previous article proposed a strategy to fabricate a hydrophilic-coated anti-biofouling BHV using PAA and PDMS in the inner and outer valves ( Lei et al, 2021 ). We evaluated the anti-biofouling properties, including anti-coagulation, anti-cell adhesion, anti-calcification, and ability to resist BSA adsorption, both in vivo and in vitro ( Figure 7 ).…”

Section: Anti-biofouling Polymers With Special Surface Wettability For Biomedical Applicationsmentioning

confidence: 99%

Anti-Biofouling Polymers with Special Surface Wettability for Biomedical Applications

Yang

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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The use of anti-biofouling polymers has widespread potential for counteracting marine, medical, and industrial biofouling. The anti-biofouling action is usually related to the degree of surface wettability. This review is focusing on anti-biofouling polymers with special surface wettability, and it will provide a new perspective to promote the development of anti-biofouling polymers for biomedical applications. Firstly, current anti-biofouling strategies are discussed followed by a comprehensive review of anti-biofouling polymers with specific types of surface wettability, including superhydrophilicity, hydrophilicity, and hydrophobicity. We then summarize the applications of anti-biofouling polymers with specific surface wettability in typical biomedical fields both in vivo and in vitro, such as cardiology, ophthalmology, and nephrology. Finally, the challenges and directions of the development of anti-biofouling polymers with special surface wettability are discussed. It is helpful for future researchers to choose suitable anti-biofouling polymers with special surface wettability for specific biomedical applications.

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“…In our previous publications, we discussed the relationship between antifouling and surface wettability ( He et al, 2021a ; He et al, 2021b ; Lan et al, 2021 ; Lei et al, 2021 ). For example, we summarized the frequent strategies to achieve anti-biofouling polymers for biomedical applications based on different types of surface wettability ( He et al, 2021a ), including superhydrophilicity ( Figure 1A ), hydrophilicity ( Figure 1B ), hydrophobicity ( Figure 1C ), and superhydrophobicity ( Figure 1D ).…”

Section: Introductionmentioning

confidence: 99%

A versatile “3M” methodology to obtain superhydrophobic PDMS-based materials for antifouling applications

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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Fouling, including inorganic, organic, bio-, and composite fouling seriously affects our daily life. To reduce these effects, antifouling strategies including fouling resistance, release, and degrading, have been proposed. Superhydrophobicity, the most widely used characteristic for antifouling that relies on surface wettability, can provide surfaces with antifouling abilities owing to its fouling resistance and/or release effects. PDMS shows valuable and wide applications in many fields, and due to the inherent hydrophobicity, superhydrophobicity can be achieved simply by roughening the surface of pure PDMS or its composites. In this review, we propose a versatile “3M” methodology (materials, methods, and morphologies) to guide the fabrication of superhydrophobic PDMS-based materials for antifouling applications. Regarding materials, pure PDMS, PDMS with nanoparticles, and PDMS with other materials were introduced. The available methods are discussed based on the different materials. Materials based on PDMS with nanoparticles (zero-, one-, two-, and three-dimensional nanoparticles) are discussed systematically as typical examples with different morphologies. Carefully selected materials, methods, and morphologies were reviewed in this paper, which is expected to be a helpful reference for future research on superhydrophobic PDMS-based materials for antifouling applications.

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Multifarious anti-biofouling bioprosthetic heart valve materials with the formation of interpenetrating polymer network structures

Cited by 13 publications

References 86 publications

Double‐Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves

Double‐Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves

Anti-Biofouling Polymers with Special Surface Wettability for Biomedical Applications

A versatile “3M” methodology to obtain superhydrophobic PDMS-based materials for antifouling applications

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