Anti-Biofouling Polymers with Special Surface Wettability for Biomedical Applications

He, Zhoukun; Yang, Xiaochen; Wang, Na; Mu, Linpeng; Pan, Jing; Lan, Xiaorong; Li, Hongmei; Dèng, Fēi

doi:10.3389/fbioe.2021.807357

Cited by 27 publications

(20 citation statements)

References 147 publications

(183 reference statements)

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“…The photo-induced hydrophilicity of TiO 2 has been reported in many pieces of literature ( Carp et al, 2004 ). Excellent hydrophilicity is considered to facilitate biofouling resistance ( He et al, 2021 ). Compared with the non-photo-functionalized UNT-Ag@TiO 2 NPs coatings, the photo-functionalized UV-Ag@TiO 2 NPs coatings showed a significant decrease in WCA and exhibited strong photo-induced hydrophilicity ( Figure 2D ), which means that photo-functionalized nanoparticle coatings may be somehow more anticoagulant and antibacterial than their counterparts in the group.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide

Xiao

Dai

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Silver nanoparticles (AgNPs) are widely used because of their excellent antimicrobial properties. However, the poor hemocompatibility limits the application of AgNPs in blood contact materials. General approaches to improve the hemocompatibility of AgNPs-containing surfaces are to construct barrier layers or co-immobilize anticoagulant biomolecules. But such modification strategies are often cumbersome to prepare and have limited applications. Therefore, this study proposes a simple UV-photo-functionalization strategy to improve the hemocompatibility of AgNPs. We loaded AgNPs onto titanium dioxide (TiO2) nanoparticles to form a composite nanoparticles (Ag@TiO2NPs). Then, UV treatment was performed to the Ag@TiO2NPs, utilizing the diffusible photo-induced anticoagulant properties of TiO2 nanoparticles to enhance the hemocompatibility of AgNPs. After being deposited onto the PU surface, the photo-functionalized Ag@TiO2NPs coating showed excellent antibacterial properties against both Gram-positive/Gram-negative bacteria. Besides, In vitro and ex-vivo experiments demonstrated that the photo-functionalized Ag@TiO2NPs coating had desirable hemocompatibility. This modification strategy can provide a new solution idea to improve the hemocompatibility of metal nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide

Xiao

Dai

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…Moreover, the binding of Vit D to the PEG and combining with Cur on one scaffold enhanced its hydrophilicity. The hydrophilicity of the scaffold plays an important role in biological effects, which could enhance the appropriate for blood coagulation, osteogenic induction, and osteointegration ( He et al, 2021a ; He et al, 2021b ). Therefore, mimicking the in vivo environment and the natural physiological microenvironment, drug release testing at pH 7.4 was required to ensure adequate drug delivery in the defect and complete osseointegration success ( Nourbakhsh et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold

Al-Bishari

Al-Shaaobi²,

Al-Bishari³

et al. 2022

Front. Bioeng. Biotechnol.

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The accelerating bone healing process is still a major challenge in clinical orthopedics, especially in critical-sized bone defects. Recently, Nanofiber membranes are showing increasing attention in the biomedical field due to their good biocompatibility, mechanical stability, and the ability to work as a drug carrier to achieve localized and sustained drug delivery. Herein, a multifunction nanofiber membrane loaded with vitamin D (Vit D) and curcumin (Cur) was successfully fabricated using electrospinning technology. In addition, we innovatively modified Vit D with PEG to improve the hydrophilicity of PCL nanofibers. The vitro results of CCK-8, alkaline phosphatase (ALP) and mineralization demonstrated that the PCL/Vit D-Cur membrane had great potential for enhancing the proliferation/differentiation of osteoblasts. Moreover, the synergistic effect of Vit D-Cur loaded PCL nanofiber membrane showed a superior ability to improve the anti-inflammatory activity through M2 polarization. Furthermore, in vivo results confirmed that the defect treated with PCL/Vit D-Cur nanofiber membrane was filled with the newly formed bone after 1 month. These results indicate that the Vit D/Cur loaded membrane can be applied for potential bone regeneration therapy.

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“…Biofouling means the undesired adsorption and adhesion of biomolecules, cells, or microorganisms, and the formation of microbial films on material surfaces [ 26 ]. Since these biofouling components would induce inflammatory responses and potentially cause infection and/or immunologic rejection, the property of anti-biofouling is significantly relevant to the durability and security of medical applications, for example, medical implants, contact lenses, catheters, hemodialyzers, biosensors, and respirators [ 26 , 27 , 28 , 29 ]. Antifouling polymers or coatings modified onto these medical devices change their surface characteristics and thus improve biocompatibility and the performance in resisting biofouling.…”

Section: The Main Types Of Iols Used For Pco Prophylaxismentioning

confidence: 99%

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

Zhang

Zhang²,

Chen³

et al. 2022

Pharmaceutics

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Posterior capsular opacification (PCO) is the most common complication resulting from cataract surgery and limits the long-term postoperative visual outcome. Using Nd:YAG laser-assisted posterior capsulotomy for the clinical treatment of symptomatic PCO increases the risks of complications, such as glaucoma, retinal diseases, uveitis, and intraocular lens (IOL) pitting. Therefore, finding how to prevent PCO development is the subject of active investigations. As a replacement organ, the IOL is implanted into the lens capsule after cataract surgery, but it is also associated with the occurrence of PCO. Using IOL as a medium for PCO prophylaxis is a more facile and efficient method that has demonstrated various clinical application prospects. Thus, scientists have conducted a lot of research on new intraocular lens fabrication methods, such as optimizing IOL materials and design, and IOL surface modification (including plasma/ultraviolet/ozone treatment, chemical grafting, drug loading, coating modification, and layer-by-layer self-assembly methods). This paper summarizes the research progress for different types of intraocular lenses prepared by different surface modifications, including anti-biofouling IOLs, enhanced-adhesion IOLs, micro-patterned IOLs, photothermal IOLs, photodynamic IOLs, and drug-loading IOLs. These modified intraocular lenses inhibit PCO development by reducing the residual intraoperative lens epithelial cells or by regulating the cellular behavior of lens epithelial cells. In the future, more works are needed to improve the biosecurity and therapeutic efficacy of these modified IOLs.

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Anti-Biofouling Polymers with Special Surface Wettability for Biomedical Applications

Cited by 27 publications

References 147 publications

Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide

Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide

Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

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