Multiepitope peptide-loaded virus-like particles as a vaccine against hepatitis B virus-related hepatocellular carcinoma

Ding, Fei-Xiang; Wang, Fang; Lu, Yiming; Li, Ka; Wang, Kaihui; He, Xiaozhou; Sun, Shuhan

doi:10.1002/hep.22816

Cited by 69 publications

(59 citation statements)

References 44 publications

(100 reference statements)

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“…This is likely due to a lower tendency for metastasis towards the perihepatic lymph nodes and a higher rate of encapsulation in ICC patients with HBV (66,67). In addition, the immunological memory caused by a previous HBV infection may be quickly activated by the HBV-relevant ICC, promoting antitumour immunity (68,69).…”

Section: Overall Survivalmentioning

confidence: 99%

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

Qin

Zhang

et al. 2017

Molecular and Clinical Oncology

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Abstract. High Glasgow Prognostic Score (GPS) has been associated with poor prognosis in patients with lung, ovarian, colorectal and renal cancer, as well as hepatocellular carcinoma. The aim of this study was to investigate the prognostic value of GPS in patients with intrahepatic cholangiocarcinoma (ICC) undergoing partial hepatectomy. A total of 72 patients with pathologically confirmed ICC were classified according to their GPS scores assigned based on the preoperative levels of C-reactive protein (CRP) and albumin. Their clinicopathological data were retrospectively assessed using univariate and multivariate analysis to determine their association with overall survival and recurrence. High GPS scores in ICC patients were associated with preoperative levels of CRP (P<0.001) and albumin (P<0.001), frequency of ascites accumulation (P=0.035), lymph node metastasis (P=0.002) and tumour size (P=0.005). On univariate analysis, preoperative levels of CRP (P<0.001), albumin (P=0.016) and carbohydrate antigen 19-9 (P=0.038), hepatitis B virus (HBV) positivity (P=0.009), occurrence of lymph node metastasis (P=0.001), Child-Pugh class B (P=0.013) and high tumour-node-metastasis (TNM) stage (P=0.002) were found to be associated with the 1-and 3-year overall survival. Multivariate analysis suggested that GPS score (HR=2.037, 95% CI: 1.092-3.799, P=0.025), TNM classification (HR=2.000, 95% CI: 1.188-3.367, P=0.009) and HBV positivity (HR=0.559 95% CI: 0.328-0.953, P=0.032) were independently associated with patient survival. High GPS scores also predicted ICC recurrence. In conclusion, our results demonstrated that GPS may serve as an independent marker of prognosis in patients with ICC following partial hepatectomy.

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Section: Overall Survivalmentioning

confidence: 99%

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

Qin

Zhang

et al. 2017

Molecular and Clinical Oncology

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“…65 Ichihashi et al subcutaneously vaccinated HLA-A24 transgenic mice with the three most immunogenic and highly conserved epitopes among three different influenza A virus subtypes (H1N1, H3N2, and H5N1), and the results showed that more than half of the mice survived a lethal influenza virus challenge during both effector and memory CTL phases. 69 These researchers immunized HLA-A*0201…”

Section: Kloverpris Et Al Induced Novel Cd8mentioning

confidence: 99%

“…69 Muderspach et al conducted a Phase I trial to evaluate the peptide vaccines HPV16 E7 [12][13][14][15][16][17][18][19][20] and E7 [86][87][88][89][90][91][92][93] . 70 These researchers immunized 18 HLA-A2-positive women with high-grade cervical or vulvar intraepithelial neoplasia who were positive for HPV16.…”

Section: Kloverpris Et Al Induced Novel Cd8mentioning

confidence: 99%

Advances in the study of HLA-restricted epitope vaccines

Zhao¹,

Zhang

Cong³

2013

vaccines

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“…COX-2 321 (p321, ILIGETIKI) were used as a positive control in the T2 binding and ELISPOT assay [19]. Irrelevant peptide HBc [18][19][20][21][22][23][24][25][26][27] (FLPSDFFPSI) was selected as a negative control in the cytotoxic assay in vitro. The IA b -restricted HBV core antigen-derived T helper epitope (sequence 128-140: TPPAYRPPNAPIL) was used as the T helper epitope in the in vivo assay [20,21].…”

Section: Methodsmentioning

confidence: 99%

Identification of a Novel CD8+ T Cell Epitope Derived from Cancer‐Testis Antigen MAGE‐4 in Oesophageal Carcinoma

Gao

et al. 2011

Scand J Immunol

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MAGE‐4 is considered as an attractive cancer‐testis (CT) antigen for tumour immunotherapy, and it is overexpressed in oesophageal carcinoma (EC). To identify MAGE‐4‐derived HLA‐A2 restricted epitopes, native peptides and their analogues were predicted with prediction programs. The native peptide, p286 (KVLEHVVRV), and its analogues, p286‐1Y2L and p286‐1Y2L9L, showed potent binding affinity and stability towards HLA‐A*0201 molecule. Cytotoxic T lymphocytes (CTLs) induced by p286‐1Y2L9L could release IFN‐γ in ELISPOT assay. In cytotoxicity assay, p286‐1Y2L9L showed the capability to induce specific CTLs which could lyse the target cancer cells from both PBMCs of healthy donors and HLA‐A2.1/Kb transgenic mice. Our results indicated that the peptide p286‐1Y2L9L could serve as a novel candidate epitope to develop peptide vaccines against oesophageal carcinoma.

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Multiepitope peptide-loaded virus-like particles as a vaccine against hepatitis B virus-related hepatocellular carcinoma

Abstract: To develop a hepatitis B virus (HBV) therapeutic vaccine that can induce a broad but specific immune response and significant antitumor effects both in vivo and in vitro, we inserted HBV X protein (HBx)-derived epitopes HBx

Cited by 69 publications

References 44 publications

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

Advances in the study of HLA-restricted epitope vaccines

Identification of a Novel CD8+ T Cell Epitope Derived from Cancer‐Testis Antigen MAGE‐4 in Oesophageal Carcinoma

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