Multidrug resistant neonatal sepsis in Peshawar, Pakistan

Rahman, Salim Ur

doi:10.1136/fn.87.1.f52

Cited by 79 publications

(80 citation statements)

References 18 publications

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“…In this study the gram negative rods were the main cause of septicaemia. [8][9][10][11][12] Identified as E.coli 22 (27.50%), Klebsiella pneumonia 14(17.50%), Pseudomonas 10 (12.50%), this is approximately same as Rao Pooja et al says that Klebsiella spp. (15.5%), in another study isolation rate of K. pneumonia, S. aureus, E. coli were 22.41%, 18.37%, 6.12% respectively.…”

Section: Discussionsupporting

confidence: 65%

Microbiological study of neonatal sepsis in a tertiary care hospital of western Uttar Pradesh, India

Garg

Kumar

2016

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 65%

Microbiological study of neonatal sepsis in a tertiary care hospital of western Uttar Pradesh, India

Garg

Kumar

2016

Int J Res Med Sci

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“…Recent data from Pakistan also revealed that Staph. aureus, klebsiella, and E. coli were the common organisms isolated in neonatal units at Karachi 11,12 .…”

Section: Discussionmentioning

confidence: 99%

Bacteriological Analysis and Antibiotic Sensitivity Pattern of Blood Culture Isolates in Kanti Children Hospital

Karki

Kumar

Manandhar

2010

J. Nepal Paedtr. Soc.

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Introduction: As antibiotic sensitivity pattern to common pathogen has been changing day by day, so it has been necessary to study about bacteriological analysis and antibiotic sensitivity pattern. Therefore, the purpose of this study was to analyze on data on bacteremia in children, the pathogen involved and sensitivity pattern. Objectives: The aim of this study was to determine the bacteriological profile and antibiotic sensitivity pattern of blood culture isolates from Kanti Children Hospital. Method: All blood culture reports (n=9856) during one year period (April 2007 to March 2008 included in the study were analyzed and the sensitivity pattern were recorded. In this retrospective study, we reviewed records of patients from Kanti Children Hospital from April 2007 to March 2008. Results: The positivity of blood culture was 4.2% (414/9856). Out of them, 269 (65%) were positive for Staphylococcus aures, 121(29.3%) E coli, 13(3.1%) Klebsiella pneumonia, 6(1.4%) Streptococcus pneumonia and 5(1.2%) Streptococcus viridence. Staphylococcus aureus was found most sensitive to Chloramphenicol (88.8%) followed by Amikacin (87.5%), Ofloxacin (76.5%), Ciprofloxacin (72%) and least sensitive to Ampicillin, Cloxacillin and Penicillin. E.coli was found most sensitive to Amikacin (74.7%) followed by Ofloxacin (69.9%), Ciprofloxacin (56.4%) and least sensitive to Cephalexin, Gentamycin and Ampicillin. Klebsiella pneumoniae was found most sensitive to Amikacin (91.7%) followed by Ofloxacin (87.5%), Chloramphenical (81.8%) and least sensitive to Cotrimoxazole and Gentamycin. It is 100% resistance to Ampicillin and Erythromycin. Streptococcus pneumoniae was most sensitive to Penicillin, Chloramphenical (100%) followed by Ampicillin and Erythromycin (83.3%) and least sensitive to Cotrimoxazole. Streptococcus viridence was most sensitive to Chloramphenical (100%) followed by Erythromycin (80%), Penicillin (75%) and least sensitive to Cotrimoxazole. Conclusion: This highlights the variable nature of antibiotic susceptibility patterns both in time and location around different geographical locations and within the same country as well. Therefore, it is advisable to continuously evaluate the sensitivity-resistance pattern of isolates so as to make a rational use of antibiotics.

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“…[7][8][9][10] Regular institutional-level surveillance is needed because of the constant shift in regional and institutional neonatal sepsis pathogen profiles and antimicrobial susceptibility patterns. 7,11,12 Ampicillin and gentamicin are the World Health Organization' s recommended firstline antibiotics for the empirical treatment of early-onset neonatal sepsis. 13 Periodic validation of this empirical antibiotic treatment regimen against the institution' s pathogen profile is required.…”

Section: Introductionmentioning

confidence: 99%

Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

Mudzikati

Dramowski

2015

Southern African Journal of Infectious Diseases

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Background: Septicaemia is the third most common cause of neonatal death after prematurity and birth asphyxia. The prevalence of neonatal sepsis and the spectrum of causative microorganisms fluctuates over time, thus facility-specific surveillance of neonatal bloodstream infections is important. Increasing levels of antimicrobial resistance documented worldwide, necessitate regular monitoring of institutional resistance patterns to ensure appropriate and effective empirical antimicrobial therapy. Method:The laboratory blood culture reports and patient records from a neonatal unit at a Botswana referral hospital were retrospectively reviewed to determine the one-year prevalence of neonatal sepsis and the antimicrobial susceptibility patterns of common pathogens. Results: Of 909 neonates investigated for suspected sepsis using 1 119 blood cultures, 89 (9.8%) had laboratory-confirmed episodes of bloodstream infection (septicaemia). The most prevalent pathogens included Klebsiella pneumoniae (29.4%), group B streptococcus (16.3%) and Escherichia coli (11.9%). Blood culture contamination rates were high at 18.6% (208/1 119). Gramnegative pathogens showed low susceptibility to gentamicin (40%) and cefotaxime (47%), but high susceptibility to amikacin (86%). Streptococci and enterococci were moderately sensitive to ampicillin (79%), and fully susceptible to vancomycin. Methicillin-resistant Staphylococcus aureus was not isolated. Exposure to maternal syphilis and previous antibiotic exposure were significantly associated with neonatal septicaemia. Conclusion: Neonatal sepsis is common, with a predominance of Gram-negative pathogens. The high rate of blood culture contamination should be addressed. Emerging antibiotic resistance may require clinicians to review currently used antibiotics for the empirical treatment of late-onset neonatal septicaemia.

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Multidrug resistant neonatal sepsis in Peshawar, Pakistan

Cited by 79 publications

References 18 publications

Microbiological study of neonatal sepsis in a tertiary care hospital of western Uttar Pradesh, India

Microbiological study of neonatal sepsis in a tertiary care hospital of western Uttar Pradesh, India

Bacteriological Analysis and Antibiotic Sensitivity Pattern of Blood Culture Isolates in Kanti Children Hospital

Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

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