Microbiological study of neonatal sepsis in a tertiary care hospital of western Uttar Pradesh, India

Garg, Amit; Kumar, Deepesh; Kumar, Sanjeev

doi:10.18203/2320-6012.ijrms20161935

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…On the contrary, Marwah et al found low cephalosporin resistance which was due to common use of ciprofloxacin and amikacin in its place [ 40 ]. Fortunately, all our Klebsiella i solates were carbapenem sensitive unlike in a study by Garg et al, where it showed a 100% carbapenem resistance, probably because of the evolving resistance pattern and inappropriate use of high-end antibiotics [ 41 ].…”

Section: Discussionmentioning

confidence: 80%

Clinical and Bacteriological Profile of Neonatal Sepsis: A Prospective Hospital-Based Study

Jatsho

Nishizawa

Pelzom³

et al. 2020

International Journal of Pediatrics

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Background. Neonatal sepsis remains one of the leading causes of mortality and morbidity in developing countries. With a dearth of data on neonatal sepsis in our country, this study was conducted to determine the incidence of clinical neonatal sepsis and evaluate the clinical, bacteriological, and antimicrobial susceptibility profile of organisms. Material and Methods. A prospective cross-sectional study was conducted in the Neonatal Unit of the National Hospital from 1st January to 31st December 2016. All neonates admitted with suspected clinical sepsis were included. Sepsis screens and cultures were sent under aseptic conditions. Data was analyzed using STATA™ version 12. Clinical features and neonatal and maternal risk factors were analyzed using chi-squared test. Bacteriological profile was analyzed with descriptive statistics. Results. During the study period, incidence of culture positive neonatal sepsis was 19 per 1000 admissions with a blood culture positivity rate of 14%. 54.5% had culture-positive early-onset sepsis (EOS). Prematurity (p=0.012), APGAR<6 (p=0.018), low birth weight (p<0.001), and maternal intrapartum antibiotics (p=0.031) significantly increased risk for culture-positive EOS. Prematurity (p<0.001), low birth weight (p=0.001), and parental nutrition (p=0.007) were significantly associated with increased risk of culture-positive late-onset sepsis. A positive screen had sensitivity of 81.8% and negative predictive value of 87.7%. Gram-negative organisms were most commonly isolated (64.6%). Coagulase-negative Staphylococci (31%) were the commonest isolate followed by Klebsiella pneumoniae (27%) and Acinetobacter (18.8%). Ninety percent of Acinetobacter were carbapenem resistant. Gram-negative sepsis had mortality of 88.9%. Conclusion. Preterm, low birth weight, low APGAR scores, intrapartum antibiotics, and parental nutrition were significantly associated with neonatal sepsis. Coagulase-negative Staphylococci, Klebsiella pneumoniae, and Acinetobacter were the principal causative organisms. Gram-negative organisms had high resistance to commonly used antibiotics.

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Section: Discussionmentioning

confidence: 80%

Clinical and Bacteriological Profile of Neonatal Sepsis: A Prospective Hospital-Based Study

Jatsho

Nishizawa

Pelzom³

et al. 2020

International Journal of Pediatrics

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“…According to the World Health Organization (WHO), 1.6 million newborn babies die worldwide each year as a result of neonatal infections. Despite recent advances in neonatal intensive care and current strategies to treat neonatal sepsis, mortality rates for babies born to mothers who received intrapartum antibiotic prophylaxis (IAP) for Group B Streptococcus have remained stable for more than three decades [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Microbial Pattern of Neonatal Sepsis in the Neonatal Intensive Care Unit of dr. Ramelan Navy Central Hospital

Miranda,

Harahap,

Husada

et al. 2024

International Journal of Pediatrics

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Background. The morbidity and mortality rates from neonatal sepsis remain high. However, there is limited information about the microbial pattern of neonatal sepsis in Indonesia. Microbial patterns can give an overview of the hygiene of an environment and act as a determinant for choosing definitive antibiotic treatment in neonatal sepsis patients. The organisms that cause neonatal sepsis differ from unit to unit and from time to time within the same unit. Objectives. This study is aimed at discovering the microbial pattern of neonatal sepsis in the Neonatal Intensive Care Unit (NICU), dr. Ramelan Navy Central Hospital, in 2021–2022. Methods. This is a retrospective, cross-sectional study that takes secondary data from the NICU and clinical microbiology department of dr. Ramelan Navy Central Hospital. Data that met the inclusion and exclusion criteria available between January 1, 2021, and December 31, 2022, were collected. Patients whose blood cultures were positive for bacterial growth and diagnosed with sepsis were selected as the study sample. Results. Out of 174 samples, 93 (53.4%) were found positive for bacterial infection and diagnosed as neonatal sepsis. Gram-negative isolates (96.8%) were predominant. Sixty-point-two percent of Klebsiella pneumoniae XDR, 19.4% of Klebsiella pneumoniae ESBL, and 8.6% of Burkholderia cepacia XDR were identified. The gram-positive isolates found in this study were only 3 samples (3.2%). Two-point-one percent of MRSA and 1.1% of Staphylococcus haemolyticus MDR were identified. Conclusion. The most common microorganisms causing neonatal sepsis in our NICU were gram-negative bacteria, particularly Klebsiella pneumoniae XDR. Following the recommended infection control procedures, practicing good hand hygiene, and having access to basic supplies and equipment are important to prevent and reduce the incidence of sepsis.

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Microbiological study of neonatal sepsis in a tertiary care hospital of western Uttar Pradesh, India

Cited by 2 publications

References 8 publications

Clinical and Bacteriological Profile of Neonatal Sepsis: A Prospective Hospital-Based Study

Clinical and Bacteriological Profile of Neonatal Sepsis: A Prospective Hospital-Based Study

Microbial Pattern of Neonatal Sepsis in the Neonatal Intensive Care Unit of dr. Ramelan Navy Central Hospital

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