Multidrug resistant Enterococcus faecium isolate from cholangitis/cholecystitis in a dog

Abstract

Mucocele and cholecystitis were diagnosed in a 10 year‐old Shetland‐sheepdog presenting aspecific clinical signs. Blood examinations and ultrasonography investigation were performed before to surgical approach, which allowed to collect biopsies and samples for bacteriological analyses. In addition, the patient was subjected to cholecystectomy. A multidrug resistant Enterococcus faecium was isolated from the gallbladder specimens. On the basis of antimicrobial susceptibility test, nitrofurantoin was used. The correct bacteriological diagnosis is necessary to set up effective therapy, influencing the patient's prognosis and improving the recovery time.

Does Nitrofurantoin Improve the Portfolio of Vets against Resistant Bacteria in Companion Animals?

“…The authors explained that the multidrug resistance of these two strains is commonly due to the exchange of mobile genetic elements among Enterococci, and that the presence of the same genotypes of Enterococcus spp. isolated from various animals and humans has been previously reported, suggesting interspecies transmission of strains [41].…”

“…A deep insight into the clinical application of nitrofurantoin is provided by Sposato and colleagues, who described how a successful therapeutic outcome was obtained by treating multidrug-resistant E. faecium [41]. This bacterium was isolated in a 10-year-old Shetland sheepdog affected by cholecystitis, referred for aspecific signs and symptoms.…”

“…After cholecystectomy and the collection of samples and biopsies, it was possible to isolate two strains of multiresistant E. faecium, susceptible to nitrofurantoin. The authors decided to administer nitrofurantoin following the standard dosage regimen of 5 mg/kg, every 8 h, orally, achieving a complete recovery and normalization of blood parameters after 77 days [41]. The authors explained that the multidrug resistance of these two strains is commonly due to the exchange of mobile genetic elements among Enterococci, and that the presence of the same genotypes of Enterococcus spp.…”

“…Digestive system [19,30,31,41] Genitourinary system [17,20,21,24,25,29,35,37,40,42] Integumentary system [38,39] Respiratory system [27] Whole body [18,[22][23][24]…”