Multidrug-Resistant Hospital Bacteria: Epidemiological Factors and Susceptibility Profile

Jara, Marisa Castro; Frediani, A. V.; Zehetmeyer, Fabiane Knepper; Bruhn, Fábio Raphael Pascoti; Müller, Milene Ribeiro; Miller, Róger Giusti; Nascente, Patrícia da Silva

doi:10.1089/mdr.2019.0209

Cited by 19 publications

(15 citation statements)

References 26 publications

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“…The emergence of multidrug-resistant (MDR) bacteria severely affects the health of animals, adversely affecting the economics of the livestock industry ( 4 , 5 ). Meanwhile, it also causes significant threats to patients because MDR bacteria affecting humans are closely associated with animal sources ( 6 , 7 ). In particular, “last-resort” antimicrobial resistance genes (ARGs) are continually emerging, such as the bla NDM ( 8 ), mcr ( 9 ), and tet (X) families ( 10 , 11 ), in Gram-negative bacilli.…”

Section: Introductionmentioning

confidence: 99%

Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China

Zhou

et al. 2022

Microbiol Spectr

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Section: Introductionmentioning

confidence: 99%

Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China

Zhou

et al. 2022

Microbiol Spectr

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“…The remarkable efficacy of antibiotics has encouraged their overuse, leading to an increase in bacterial resistance to these molecules and the appearance of multi-resistant strains. These bacteria, essentially of hospital origin, have spread widely in the community, creating a major public health problem [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance in uropathogenic enterobacteria

et al. 2021

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Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enterobacteriaceae and to study their antibiotic resistance profiles, thus contributing to the surveillance of antibioresistance. This is a retrospective study over a period of three years (2018-2020) including urine samples taken in the region of Rabat-Salé-Zaire and examined at the laboratory of Epidemic Diseases in National Institute of Hygiene of Rabat. Enterobacteriaceae were the most frequent germs with a predominance of Escherichia coli (68%) followed by Klebsiella pneumoniae (23%). Extended-spectrum beta-lactamase-producing Enterobacteriaceae accounted for 10.5%. The highest resistance was observed with amoxicillin, followed by ticarcillin, cefalotin, trimethoprim/sulfamethoxazole, amoxicillin+clavulanic acid, nalidixic acid and finally ciprofloxacin and norfloxacin. The aminoglycosides and the 2nd and 3rd cephalosporins were the most active molecules. The sensitivity of imipenem and ertapenem was 100%. This study shows the worrying appearance of resistance to the usual antibiotics in uropathogenic enterobacteria. Rational prescription of antibiotics and monitoring of the evolution of bacterial resistance are necessary in each region.

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“…The escalating bacterial resistance to antimicrobial agents represents a critical global issue demanding immediate attention [13]. E. coli has emerged as a prominent contributor to antimicrobial resistance, with MDR strains becoming increasingly prevalent [14]... This is particularly worrying given the current paucity of new compounds active against MDR-GNB [15].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of geraniol against E. coli infection by regulating YDIV

Long,

Dai,

Wang

et al. 2024

Preprint

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Purpose Geraniol, an active component found in the essential oil of various medicinal plants, possesses a wide range of antibacterial properties, including against E. coli. Nevertheless, the precise inhibitory mechanism of geraniol on E. coli remains elusive. Methods Co-cultivation of multidrug-resistant Escherichia coli with geraniol was performed to investigate changes in biomass, gene expression, intracellular iron concentration, phagocytic activity, and complement-mediated killing ability. Additionally, protein expression alterations were assessed to evaluate the regulatory effects of geraniol. Results The compound geraniol demonstrated a downregulation of ydiv and iron metabolism gene fepA, fecB and fhuF expression. Concomitantly, it was observed that linalool led to a decrease in intracellular iron ion concentration. Meanwhile, treatment of E. coli with geraniol resulted in a downregulation of ompW gene expression. Additionally, it led to a decrease in the killing ability of antiserum complement and an increase in the phagocytic capacity of macrophages. Furthermore, geraniol demonstrated augmented binding effects, possibly facilitated through hydrogen bonding, relying on structural simulation or MST. Conclusion These results suggested for the first time that geraniol by regulating the iron transport-related proteins YdiV, thereby decreasing the ability of antiserum complement, and an increase in the phagocytic capacity of macrophages exerting inhibited E. coli.

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Multidrug-Resistant Hospital Bacteria: Epidemiological Factors and Susceptibility Profile

Cited by 19 publications

References 26 publications

Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China

Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China

Antibiotic resistance in uropathogenic enterobacteria

Mechanism of geraniol against E. coli infection by regulating YDIV

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