Antibiotic resistance in uropathogenic enterobacteria

Abstract

Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enterobacteriaceae and to study their antibiotic resistance profiles, thus contributing to the surveillance of antibioresistance. This is a retrospective study over a period of three years (2018-2020) including urine samples taken in the region of Rabat-Salé-Zaire and examined at the laboratory of Epidemic Diseases in National Institute of Hygiene of Rabat. Enterobacteriaceae were the most frequent germs with a predominance of Escherichia coli (68%) followed by Klebsiella pneumoniae (23%). Extended-spectrum beta-lactamase-producing Enterobacteriaceae accounted for 10.5%. The highest resistance was observed with amoxicillin, followed by ticarcillin, cefalotin, trimethoprim/sulfamethoxazole, amoxicillin+clavulanic acid, nalidixic acid and finally ciprofloxacin and norfloxacin. The aminoglycosides and the 2nd and 3rd cephalosporins were the most active molecules. The sensitivity of imipenem and ertapenem was 100%. This study shows the worrying appearance of resistance to the usual antibiotics in uropathogenic enterobacteria. Rational prescription of antibiotics and monitoring of the evolution of bacterial resistance are necessary in each region.

Extended-spectrum beta-lactamase and Antibiotic susceptibility pattern in uropathogens.

“…20 Penicillin, cephalosporins, trimethoprimsulfamethoxazole, quinolones, carbapenems, aminoglycosides, 2nd, and 3rd generation cephalosporins were the most active compounds against these uropathogens, according to an analysis of non-ESBL generating strains' susceptibility to the antibiotics utilised (E. coli and K.pneumoniae). 21 The finding in our study is similar to the above study. CONCLUSION Alarmingly, 35.9% of inpatients (hospitalized) and 16.9% of outpatients (community) in the current investigation were ESBL-positive, with all extended-spectrum beta-lactamase-producing strains being multi-drug resistant.…”

Antibiotic Resistance in the Uropathogenic Enterobacteria Isolated from Patients Attending General Reference Hospital (GRH) of Niamey, Niger

“…The ticarcillin resistance rate was 95.22%. This is higher than that reported in a study by Jamila et al on antibiotic resistance in uropathogenic enterobacteria [35]. However, the resistance rate to piperacillin + tazobactam was 34.13%.…”

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

“…Our study found the prevalence of CA-UTIs is 24.27% among symptomatic patients. The observed rate is higher than the levels recorded previously in Italy (20.4%) [17], and in Morocco (17.9%) [18]. UTIs are one of the most common CA-bacterial infectious diseases worldwide, affecting patients of both genders [19].…”

“…The second most common species were Klebsiella pneumoniae and Proteus mirabilis, each of which was represented by 13 strains (11.20%). Al-Naqshbandi and Chawsheen [23] and Orrett [24] have mentioned similar results for K. pneumoniae and P. mirabilis, respectively [17,18]. Other bacterial species were infrequently isolated, namely Klebsiella oxytoca (n = 3) and Enterobacter cloacae (n = 3) followed by Enterobacter aerogenes (n= 2).…”