Multidrug-Resistant Campylobacer jejuni on Swine Processing at a Slaughterhouse in Eastern Spain

Marín, Clara; Lorenzo-Rebenaque, Laura; Moreno-Moliner, Judith; Sevilla‐Navarro, Sandra; Montero, Estefanía; Chinillac, Ma Carmen; Jordá, Jaume; Vega, Santiago

doi:10.3390/ani11051339

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…These facts point to the consequences of intensive antibiotic application. which promotes intense selection pressure on MDR Campylobacter at the end of slaughter processing, aggravating the problem at the interface of food consumption and human disease [53].…”

Section: Resistance Of Campylobacter Isolatesmentioning

confidence: 99%

Agents of Campylobacteriosis in Different Meat Matrices in Brazil

Takeuchi

Melo

Dumont

et al. 2022

IJERPH

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We aimed to identify the prevalence of thermophilic species of Campylobacter in meats of different species available on the Brazilian commercial market and to determine the genetic diversity, antimicrobial resistance and virulence potential of the isolates. A total of 906 samples, including chicken, beef and pork carcasses and chicken and beef livers, were purchased in retail outlets, and prevalences of 18.7% (46/246), 3.62% (5/138), 10.14% (14/138), 3.62% (5/138) and 4.47% (11/132), respectively, were identified, evidencing the dissemination of genotypes in the main producing macro-regions. Of all isolates, 62.8% were classified as multidrug resistant (MDR), with resistance to amoxicillin-clavulanate (49.4%), tetracycline (51.8%) and ciprofloxacin (50.6%) and co-resistance to macrolides and fluoroquinolones (37.1%). Multivirulent profiles were identified mainly in isolates from chicken carcasses (84.8%), and the emergence of MDR/virulent strains was determined in pork isolates. All isolates except those from chicken carcasses showed a high potential for biofilm formation (71.4% luxS) and consequent persistence in industrial food processing. For chicken carcasses, the general virulence was higher in C. jejuni (54.3%), followed by C. coli (24%) and Campylobacter spp. (21.7%), and in the other meat matrices, Campylobacter spp. showed a higher prevalence of virulence (57.2%). The high rates of resistance and virulence reinforce the existence of strain selection pressure in the country, in addition to the potential risk of strains isolated not only from chicken carcasses, but also from other meat matrices.

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Section: Resistance Of Campylobacter Isolatesmentioning

confidence: 99%

Agents of Campylobacteriosis in Different Meat Matrices in Brazil

Takeuchi

Melo

Dumont

et al. 2022

IJERPH

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“…These novel solutions are very useful to farmers as recently it has been reported that cattle and chickens are an important reservoir of campylobacters, associated with human disease, and resistant to erythromycin, ampicillin, tetracycline, nalidixic acid and ciprofloxacin [28]. Measures implemented at the slaughterhouse, rather than at the farm, must also be considered since contamination can also occur in such environments [29]; however, the management involved in farming activities seems to take priority in preventing Campylobacter spp. spreading in livestock [30].…”

Section: Campylobacter Spp Overviewmentioning

confidence: 99%

Overview of Virulence and Antibiotic Resistance in Campylobacter spp. Livestock Isolates

Bunduruș¹,

Balta²,

Ştef³

et al. 2023

Antibiotics

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Campylobacter remains the most prevalent foodborne pathogen bacterium responsible for causing gastroenteritis worldwide. Specifically, this pathogen colonises a ubiquitous range of environments, from poultry, companion pets and livestock animals to humans. The bacterium is uniquely adaptable to various niches, leading to complicated gastroenteritis and, in some cases, difficult to treat due to elevated resistance to certain antibiotics. This increased resistance is currently detected via genomic, clinical or epidemiological studies, with the results highlighting worrying multi-drug resistant (MDR) profiles in many food and clinical isolates. The Campylobacter genome encodes a rich inventory of virulence factors offering the bacterium the ability to influence host immune defences, survive antimicrobials, form biofilms and ultimately boost its infection-inducing potential. The virulence traits responsible for inducing clinical signs are not sufficiently defined because several populations have ample virulence genes with physiological functions that reflect their pathogenicity differences as well as a complement of antimicrobial resistance (AMR) systems. Therefore, exhaustive knowledge of the virulence factors associated with Campylobacter is crucial for collecting molecular insights into the infectivity processes, which could pave the way for new therapeutical targets to combat and control the infection and mitigate the spread of MDR bacteria. This review provides an overview of the spread and prevalence of genetic determinants associated with virulence and antibiotic resistance from studies performed on livestock animals. In addition, we have investigated the relevant coincidental associations between the prevalence of the genes responsible for pathogenic virulence, horizontal gene transfer (HGT) and transmissibility of highly pathogenic Campylobacter strains.

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“…Although the data indicated that most bacteria are still sensitive to individual antimicrobials, the multi-resistance characteristics of foodborne pathogens have been referred to as an important issue [ 173 , 174 ].…”

Section: Surveillance Of Antibiotic Resistance In the Slaughterhousementioning

confidence: 99%

The Importance of the Slaughterhouse in Surveilling Animal and Public Health: A Systematic Review

García‐Díez

Saraiva

Moura

et al. 2023

Veterinary Sciences

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From the point of public health, the objective of the slaughterhouse is to guarantee the safety of meat in which meat inspection represent an essential tool to control animal diseases and guarantee the public health. The slaughterhouse can be used as surveillance center for livestock diseases. However, other aspects related with animal and human health, such as epidemiology and disease control in primary production, control of animal welfare on the farm, surveillance of zoonotic agents responsible for food poisoning, as well as surveillance and control of antimicrobial resistance, can be monitored. These controls should not be seen as a last defensive barrier but rather as a complement to the controls carried out on the farm. Regarding the control of diseases in livestock, scientific research is scarce and outdated, not taking advantage of the potential for disease control. Animal welfare in primary production and during transport can be monitored throughout ante-mortem and post-mortem inspection at the slaughterhouse, providing valuable individual data on animal welfare. Surveillance and research regarding antimicrobial resistance (AMR) at slaughterhouses is scarce, mainly in cattle, sheep, and goats. However, most of the zoonotic pathogens are sensitive to the antibiotics studied. Moreover, the prevalence at the slaughterhouse of zoonotic and foodborne agents seems to be low, but a lack of harmonization in terms of control and communication may lead to underestimate its real prevalence.

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Multidrug-Resistant Campylobacer jejuni on Swine Processing at a Slaughterhouse in Eastern Spain

Cited by 7 publications

References 47 publications

Agents of Campylobacteriosis in Different Meat Matrices in Brazil

Agents of Campylobacteriosis in Different Meat Matrices in Brazil

Overview of Virulence and Antibiotic Resistance in Campylobacter spp. Livestock Isolates

The Importance of the Slaughterhouse in Surveilling Animal and Public Health: A Systematic Review

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