Multidrug-resistant Acinetobacter baumannii clones persist on hospital inanimate surfaces

Rocha, Igor Vasconcelos; Xavier, Danilo Elias; Almeida, Karoline Rissele Henrique de; Oliveira, Sibele Ribeiro de; Leal, Nilma Cintra

doi:10.1016/j.bjid.2018.08.004

Cited by 26 publications

(22 citation statements)

References 10 publications

(13 reference statements)

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“…These risk factors may be related to the ability of A . baumannii to colonise abiotic surfaces and medical devices, as well as the presence of comorbidities, the use of invasive procedures, and prior use of broad spectrum antibiotics[31–33]. Prior antibiotic exposures are frequently reported as a risk factor for MDR A .…”

Section: Discussionmentioning

confidence: 99%

A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

et al. 2018

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The global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) strains has restricted the therapeutic options available to treat infections due to this pathogen. Understanding the prevalence of such infections and the underlying genetic mechanisms of resistance may help in the implementation of adequate measures to control and prevent acquisition of nosocomial infections, especially in an intensive care unit setting. This study describes the molecular characteristics and risk factors associated with OXA-23-producing A. baumannii infections. A case-control study was undertaken from September/2013 to April/2015. Acquisition of OXA-23-producing A. baumannii was found to be associated with the use of nasogastric tubes, haemodialysis, and the use of cephalosporins. These isolates were only susceptible to amikacin, gentamicin, tigecycline, and colistin, and contained the ISAba1 insertion sequence upstream ofblaOXA-23 and blaOXA-51 genes. Twenty-six OXA-23-producing A. baumannii strains belonged to the ST79 (CC79) clonal group,and patients infected or colonised by these isolates had a higher mortality rate (34.6%). In conclusion, this study showed a dissemination of OXA-23-producing A. baumannii strains that was associated with several healthcare-related risk factors and high mortality rates among intensive care unit patients.

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Section: Discussionmentioning

confidence: 99%

A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

et al. 2018

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“…These represent a great challenge in terms of treatment of infections and the elimination of pathogenic Acinetobacter species. The genome plasticity of A. baumannii further enhances its ability to adapt and persist in hospital environments and has facilitated the emergence of global MDR strains (Imperi et al, 2011;McConnell et al, 2013;Elhosseiny and Attia, 2018;Rocha et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes

et al. 2020

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Sequencing Multiple Brazilian Acinetobacter Genomes genes associated with the synthesis of the capsular antigens were noticeably more variable in the ST113 and ST79 strains. Indeed, several resistance and virulence genes were common to the ST79 and ST113 strains only, despite a greater genetic distance between them, suggesting common means of genetic exchange. Our comparative analysis reveals the spread of multiple STs and the genomic plasticity of A. baumannii from different hospitals in a single metropolitan area. It also highlights differences in the spread of resistance markers and other MGEs between the investigated STs, impacting on the monitoring and treatment of Acinetobacter in the ongoing and future outbreaks.

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“…The samples were collected from four sites including the intensive care units of Surgical, Pediatric, Medical and Medical-Surgical wards of the hospital. The samples were collected on a single occasion, using pre-moistened sterile swabs from environmental surfaces and medical equipment including beds, monitors, linens, ventilators, suction machine, Lobby (furniture), work station and sinks in accordance to suggestions from previous studies [14,15].…”

Section: Study Design and Environmental Samplingmentioning

confidence: 99%

Magnitude and antimicrobial susceptibility patterns of extended-spectrum β-lactamase producing Enterobacteriaceae recovered from environmental samples at Tikur Anbessa Specialized Hospital, Ethiopia

Muktar¹,

Erku²,

Mihret³

et al. 2020

Preprint

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Background The hospital environment especially the intensive care units (ICUs) contributes to the spread of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae, which are contributing to increasing morbidity and mortality rates. We aimed to assess the rate of environmental contamination of ESBL producing Enterobacteriaceae and their antimicrobial susceptibility patterns. Methods A Cross-sectional study was conducted at Tikur Anbessa Specialized Hospital (TASH) from June to July, 2018. A total of 65 environmental swab were taken from inanimate items. All isolates from the inanimate environment were cultured by using ESBL ChromoSelect Agar and identified using conventional bacteriological methods. All ESBL producing Enterobacteriaceae isolates were tested for their antimicrobial susceptibility using the disc diffusion method according to the methods and interpretive criteria of the Clinical and Laboratory Standards Institute (CLSI). Results From a total of 65 environmental swab samples, 16 (24.6%) were ESBL producing Enterobacteriaceae. The most predominant ESBL producing isolates were E. coli (8/16, 50%) and Klebsiella spp (6/16, 37.6%). The Pediatrics and Medical-Surgical ICU exhibited the highest ESBL producing Enterobacteriaceae, each with (37.5%, 6/16). Linens and ventilators were associated with high rates of ESBL isolates positivity each with equal 31.3% detection rate. ESBL producing Enterobacteriaceae isolates had significantly high resistance level to ampicillin (100%), ceftazidime (93.8%), cefepime (87.5%) and cefotaxime (86.7%). However, low resistance level was recorded against amikacin (18.8%). Conclusion The appearance of ESBL producing Enterobacteriaceae among ICUs hospital environment is posing a serious threat for the control of nosocomial infections. The high resistance found from this study shows the need for policies for devising infection control procedures and screening policies for ESBL on a routine basis.

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Multidrug-resistant Acinetobacter baumannii clones persist on hospital inanimate surfaces

Cited by 26 publications

References 10 publications

A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes

Magnitude and antimicrobial susceptibility patterns of extended-spectrum β-lactamase producing Enterobacteriaceae recovered from environmental samples at Tikur Anbessa Specialized Hospital, Ethiopia

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