Multidrug resistance in Gram-negative bacteria that produce extended-spectrum β-lactamases (ESBLs)

Giamarellou, Helen

doi:10.1111/j.1469-0691.2005.01160.x

Cited by 71 publications

(67 citation statements)

References 115 publications

(140 reference statements)

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“…izolatları daha çok Kuzey Afrika ülkeleri, Hindistan ve Güney Kore'den rapor edilmektedir CTX-M enzimleri ise plazmid aracılı GSBL'ler içinde TEM ve SHV enzimleri ile çok ilişkili olmayan oldukça yeni bir ailedir ve başlıca S.Typhimurium ve E.coli'de saptanmış-lardır 27 . CTX-M enzimlerinden ilki, Almanya'da 1989 yılında E.coli suşunda saptanmış; CTX-M-1 olarak adlandırılmış ve CTX-M türevleri günümüzde 69'a kadar ulaşmıştır 26,27 . Klinik suşlarda, CTX-M enzimlerini kodlayan genler genellikle boyutu 7 kb'dan 160 kb'a kadar değişen plazmidler üzerinde yerleşmiştir.…”

Section: Discussionunclassified

Molecular Epidemiology, Antimicrobial Resistance and Characterization of Extended-Spectrum Beta-Lactamases of Salmonella enterica Serotype Paratyphi B Clinical Isolates

Bayramoğlu¹,

Özgümüş²,

Kolayli³

et al. 2014

Mikrobiyol Bul

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Section: Discussionunclassified

Molecular Epidemiology, Antimicrobial Resistance and Characterization of Extended-Spectrum Beta-Lactamases of Salmonella enterica Serotype Paratyphi B Clinical Isolates

Bayramoğlu¹,

Özgümüş²,

Kolayli³

et al. 2014

Mikrobiyol Bul

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“…Methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are two of the commonest MDR pathogens at present causing worldwide concern. 1,2 It is reported that 69.8% of all S. aureus isolates are resistant to oxacillin, 3 while ESBL-producing E. coli accounts for 11% of all E. coli isolates in Hong Kong. 4 Antimicrobial photodynamic inactivation (PDI) is perhaps an alternative strategy to combat these MDR pathogens.…”

Section: Introductionmentioning

confidence: 99%

A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens

Tang

Hamblin

Yow

2007

Journal of Infection and Chemotherapy

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Photodynamic inactivation (PDI) has been investigated to cope with the increasing incidence of multidrug-resistant (MDR) pathogens. In Hong Kong, methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are the two commonest MDR pathogens. Here, we studied the photodynamic inactivation (PDI) mediated by poly-L-lysine chlorin(e6) conjugate (pL-ce6) and toluidine blue O (TBO) in clinical MRSA and ESBL producing E. coli, together with their corresponding American Type Culture Collection (ATCC) strains. Both pL-ce6 and TBO mediated a light-and drug dose-dependent efficacy for the four pathogens. pL-ce6 was more effective. pL-ce6 at 8 µM, 30 Jcm −2 , attained 5 log killing for ESBL-producing E. coli and E. coli (ATCC 25922); 4 log killing for MRSA, and 3 log killing for S. aureus (ATCC 25923). TBO at 80 µM, 30 Jcm −2 , only exhibited 3 log killing in MRSA and 2 log killing in S. aureus (ATCC 25923). TBO (400 µM, 30 Jcm −2 ) induced equal killing for ESBLproducing E. coli and E. coli (ATCC 25922). Our studied MRSA isolate responded better than S. aureus (ATCC 25923). Thus, pL-ce6-mediated PDI in other MRSA isolates deserves further investigation.

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“…Generally, ESBL has been found all over the world; for example, previous studies have reported that the prevalence of ESBL in Europe is higher than the United States, but lower than South America and Asia (Giamarellou, 2005). Asia is almost certainly a part of the world, in which the prevalence of ESBLs is very high among GNBs; however, Figure 1: Representation of the frequency of ESBL production (no.…”

Section: Introductionmentioning

confidence: 99%

Extended-Spectrum Beta-Lactamase Producing Gram Negative Bacteria in Iran: A Review

Leylabadlo¹,

Pourlak²,

Bialvaei³

et al. 2017

AJID

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Background: The emergence and spread of extended spectrum β-lactamase (ESBL)-producing Gram-negative bacteria (GNB), particularly in Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa, have increased all over the world. ESBLs are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. The rate of nosocomial infections caused by ESBL-producing GNB in Asia Pacific has increased and several studies have identified their prevalence in the region. The aim of this study is to review the prevalence of ESBL-producing GNB in the West Asia and the Middle East with a particular focus on Iran. Materials and Methods: The available evidence from various studies (Microbia and clinical studies, retrieved from the PubMed, and Scopus databases) regarding the ESBL producing Gram negative bacteria in Iran were evaluated. Results:In almost all parts of the country, high resistance has been observed, especially in the central part of Iran. Up to 89.8% Escherichia coli, 72.1% Klebsiella pneumonia, 84.2% Acinetobacter baumannii, and 83.8% Pseudomonas aeruginosa isolates are ESBL positive. Conclusion:The present study showed the increasing prevalence of ESBLs in different regions of Iran, which could be useful to strategic policy towards reducing reduce their prevalence.

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Multidrug resistance in Gram-negative bacteria that produce extended-spectrum β-lactamases (ESBLs)

Cited by 71 publications

References 115 publications

Molecular Epidemiology, Antimicrobial Resistance and Characterization of Extended-Spectrum Beta-Lactamases of Salmonella enterica Serotype Paratyphi B Clinical Isolates

Molecular Epidemiology, Antimicrobial Resistance and Characterization of Extended-Spectrum Beta-Lactamases of Salmonella enterica Serotype Paratyphi B Clinical Isolates

A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens

Extended-Spectrum Beta-Lactamase Producing Gram Negative Bacteria in Iran: A Review

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