Molecular Epidemiology, Antimicrobial Resistance and Characterization of Extended-Spectrum Beta-Lactamases of Salmonella enterica Serotype Paratyphi B Clinical Isolates

Bayramoğlu, Gülçin; Özgümüş, Osman Birol; Kolayli, Fetiye; Kamburoğlu, A; Beşli, Yeşim; Dinc, Ugur; Tosun, İlknur; Aydın, Faruk

doi:10.5578/mb.7389

Cited by 3 publications

(3 citation statements)

References 12 publications

(16 reference statements)

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“…Almost 50% of patients were found resistant to ceftriaxone in our study; studies from different parts of the world also show that ceftriaxone resistance is increasing [9,10]. However, some studies from Pakistan have shown less than one percent resistance to ceftriaxone [6].…”

Section: Discussionsupporting

confidence: 54%

“…Increasing resistance of Salmonella Typhi is alarming; new extensively drug-resistant (XDR) strains reported first time in Pakistan, resistant not only to first-line drugs and ciprofloxacin but also resistant to ceftriaxone, had spread globally, including the USA [8]. Studies have shown that resistance to ceftriaxone is increasing globally [9,10]. This rise in antibiotic resistance has increased morbidity, mortality, and treatment cost of typhoid fever [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Sensitivity Pattern of Salmonella Typhi: Emergence of Resistant Strains

Shah

Nadeem²,

Syed

et al. 2020

Cureus

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Background Typhoid fever is still an important public health problem in developing countries. Increasing resistance of Salmonella Typhi to antibiotics is alarming. New extensively drug-resistant strains of Salmonella reported first time in Pakistan, resistant not only to first-line drugs and ciprofloxacin but also resistant to ceftriaxone, had spread globally, including the USA. Due to this continuously changing pattern of antimicrobial resistance in typhoid fever due to Salmonella Typhi, there is a substantial need to study the resistance pattern of Salmonella Typhi frequently in different areas to detect the new resistant strains timely. The objective of this study was to evaluate the current trends in the resistance pattern of Salmonella Typhi in a tertiary care hospital in Northern Punjab.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Sensitivity Pattern of Salmonella Typhi: Emergence of Resistant Strains

Shah

Nadeem²,

Syed

et al. 2020

Cureus

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“…Studies from different parts of the world also show that ceftriaxone resistance is increasing (Bayramoglu et al, 2014). However, some studies have shown less than one percent resistance to ceftriaxone (Qamar et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Socio-Demographic Factors Affecting the Prevalence of Typhoid Fever Among Febrile Patients in Kebbi State, Nigeria

Faruku,

Sarkinfada,

Hafiz

et al. 2024

dujopas

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Typhoid fever is a life-threatening public health disease caused by the bacterium Salmonella Typhi. The disease is a significant health concern in underdeveloped and most developing countries, especially in Asia and Africa (including Nigeria). The study was aimed at determining the prevalence and sociodemographic factors associated with typhoid fever among febrile patients attending three selected hospitals in Kebbi State, Nigeria. A hospital based cross sectional study was carried out among 406 febrile patients suspected of typhoid fever aged 1-70 years (mean age 34 years) in three selected health facilities of Kebbi State, Nigeria from February2021 to October, 2021. Approximately 20 ml and 10 ml of venous blood was collected from adults and children respectively. Blood culture and biochemical tests were carried out. Patients were administered structured questionnaires to evaluate the level of knowledge and practice toward the disease. Data obtained from respondents was analysed by descriptive statistics. In this study, the culture identified Salmonella Typhi prevalence of typhoid fever among febrile study subjects in Kebbi State was 6.4%. A higher prevalence was recorded among males (7.5%) than in females (5.0%) participants. Patients within the age range of 11- 20 years had the highest prevalence (14.8%), those with informal education recorded 11.2%. It was observed that rural area dwellers had higher prevalence (9.4%). Out of 26 isolates, 25 were susceptible to cefotaxime, 11 isolates were resistant to cotrimoxazole and amoxicillin-clavulanate antibiotics. Salmonella enterica serovar Typhi is an important and common cause of febrile illness in our population. Lack of good quality drinking water in rural areas has a greater impact on the burden of typhoid fever among study participants. Cefotaxime and ciprofloxacin therapy are suitable treatments for typhoid fever. The identification of sociodemographic characteristics associated with the disease are of great importance in providing holistic preventive approach and control strategies of the disease.

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Effects of sub-MIC antibiotic concentrations on biofilm production of Salmonella Infantis

Tezel

Akçelik

Yüksel

et al. 2016

Biotechnology & Biotechnological Equipment

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In the present study, 13 Salmonella Infantis strains, which have been originated from Turkey, were selected due to their clinical and industrial relevance, sufficient biofilm producing capability and multidrug resistance. Although all tested strains were built up of thin pellicle, optimum pellicle formation has occurred at 28 C. All S. Infantis biofilms were categorized as 'bdar' morphotype following the incubation at both 20 and 28 C, while they were categorized as 'saw' morphotype at 37 C. Under a certain incubation temperature (28 C), 84.62% of strains have formed strong biofilm structures. By using the disk diffusion method, high levels of resistance have been observed among tested bacteria against nalidixic acid (100%), spectinomycin (100%), streptomycin (92.3%), tetracycline (92.3%), kanamycin (76.9%) and neomycin (76.9%). Further studies were performed with S. Infantis DMC 12 strain, due to its capability to produce biofilm and multidrug resistance phenotype. Gentamycin (>64 mg/mL, 2 £ MIC) and tetracycline (>128 mg/mL, 4 £ MIC) were determined as the most effective antibiotics against biofilm formation. The biofilm forms have showed increased antimicrobial resistance when it was compared to the planktonic bacteria. The highest resistance rates of the biofilm bacteria were observed to neomycin (12 £ MIC) followed by spectinomycin (10 £ MIC) and streptomycin (10 £ MIC). Biofilm structure was induced as a result of nalidixic acid, spectinomycin, tetracycline and neomycin treatment at sub-MIC concentrations of tested antibiotics.

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Molecular Epidemiology, Antimicrobial Resistance and Characterization of Extended-Spectrum Beta-Lactamases of Salmonella enterica Serotype Paratyphi B Clinical Isolates

Cited by 3 publications

References 12 publications

Antimicrobial Sensitivity Pattern of Salmonella Typhi: Emergence of Resistant Strains

Antimicrobial Sensitivity Pattern of Salmonella Typhi: Emergence of Resistant Strains

Socio-Demographic Factors Affecting the Prevalence of Typhoid Fever Among Febrile Patients in Kebbi State, Nigeria

Effects of sub-MIC antibiotic concentrations on biofilm production of Salmonella Infantis

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