Multidrug donor preconditioning protects steatotic liver grafts against ischemia-reperfusion injury

Heesen, Maximilian von; Seibert, Katharina; Hulser, Matthias; Scheuer, Cláudia; Wagner, Mathias; Menger, Michael D.; Schilling, Martin K.; Moussavian, M. R.

doi:10.1016/j.amjsurg.2011.01.026

Cited by 25 publications

(27 citation statements)

References 45 publications

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“…Twenty-seven studies utilizing the thiobarbituric acid reactive substances assay showed significantly increased levels of MDA in steatotic livers post-IRI [20,21,23,25,28,32,34,38,40,44,46,48,52,54,55,57,[61][62][63]69,[71][72][73][75][76][77][78] while Nakano and colleagues [17] reported similar levels of perfusate MDA to that seen from lean livers. Serviddio et al [47] also reported a significant increase in mitochondrial 4-hydroxy-2-nonenal-protein adducts post-IRI in steatotic livers.…”

Section: Lipid Peroxidationmentioning

confidence: 95%

“…Glutamate dehydrogenase is a mitocho ndrial enzyme and increases in glutamate dehydrogenase release were used to reflect leakage from damaged or necrotic hepatocytes [67]. Eleven studies reported on glutamate dehydrogenase and in all cases, steatotic livers showed a significant increase in glutamate dehydrogenase levels in the perfusate post-IRI indicating increased mitochondrial damage in steatotic livers [61,62,67,68,[71][72][73][74][75][76][77].…”

Section: Glutamate Dehydrogenase and Superoxidementioning

confidence: 99%

“…QUORUM Diagram. [18]; b, [19]; c, [20]; d, [21]; e, [22]; f, [23], g, [24]; h, [25]; i, [26]; j, [27]; k, [28]; l, [29]; m, [30]; n, [17]; o, [31]; p, [32]; q, [33]; r, [34]; s, [35]; t, [36]; u, [37] [38]; b, [39]; c, [40]; d, [41]; e, [42]; f, [43]; g, [44]; h, [45]; i, [46]; j, [47]; k, [48]; l, [49]; m, [50]; n, [51]; o, [52] [62]; c, [63]; d, [64]; e, [65]; f, [66]; g, [67]; h, [68]; i, [69]; j, [70]; k, [71]; l, [17]; m, [60]; n, [72]; o, [73]<...>…”

Section: Papers Identified From Reference Lists N=19mentioning

confidence: 99%

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Effect of Hepatic Steatosis on Bioenergetic Function During Hepatic Ischemia-reperfusion: A Systematic Review

Chu¹

2013

TOTRANSJ

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Abstract:Background: The impact of hepatic steatosis on bioenergetics following hepatic ischemia-reperfusion injury (IRI) remains controversial and is associated with variable reports on its outcome. Large numbers of studies have been published examining the relationship between hepatic steatosis and cellular bioenergetics following hepatic IRI. This systematic review evaluates these studies.Methods: An electronic search of the Medline and Embase databases (January 1946 to June 2012) was performed to select studies that reported relevant outcomes in animal models or patients with hepatic steatosis subjected to IRI.Results: A total of 489 articles were identified, of which 63 animal studies met the predefined criteria and were included in the study. There was large variation in the type of animal model, duration and type of IRI utilized and histological description of hepatic steatosis. Bioenergetic impairments appear to increase the susceptibility of steatotic livers to IRI. The most common impairment was decreased adenosine triphosphate recovery with increased oxidative stress following IRI. Impaired mitochondrial function play a key role in the susceptibility of steatotic livers to IRI.Conclusions: Animals with >30% hepatic steatosis have been shown to have poor outcome following IRI. Despite limitations of different experimental models and inconsistency in histological description, impaired mitochondrial function and bioenergetics appear to be important mediators in the decreased tolerance of steatotic livers to IRI. Future studies need to be consistent and clinically relevant to further improve our understanding of this issue.

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Section: Lipid Peroxidationmentioning

confidence: 95%

Section: Glutamate Dehydrogenase and Superoxidementioning

confidence: 99%

Section: Papers Identified From Reference Lists N=19mentioning

confidence: 99%

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Effect of Hepatic Steatosis on Bioenergetic Function During Hepatic Ischemia-reperfusion: A Systematic Review

Chu¹

2013

TOTRANSJ

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“…The authors observed that the addition of melatonin induced a decrease of TNF-α and intercellular adhesion molecule 1 (ICAM1) levels (ICAM1 is induced by TNF-α and IL-1), with a significant attenuation of hepatic leukocyte infiltration, vacuolization, and cell death. This group also observed that with the multidrug treatment, MDA levels also lowered liver enzymes and excretory liver function levels were recovered to nearly control levels (von Heesen et al 2012). These authors also used another multidrug treatment based on curcumin (50 mg/kg intragastric), simvastatin (5 mg/kg intrasgastric), NAC (150 mg/kg i.p.…”

Section: Liver Transplantationmentioning

confidence: 96%

Potential benefits of melatonin in organ transplantation: a review

Esteban‐Zubero

García-Gil

López-Pingarrón

et al. 2016

Journal of Endocrinology

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Organ transplantation is a useful therapeutic tool for patients with end-stage organ failure; however, graft rejection is a major obstacle in terms of a successful treatment. Rejection is usually a consequence of a complex immunological and nonimmunological antigen-independent cascade of events, including free radical-mediated ischemia-reperfusion injury (IRI). To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. Melatonin (N-acetyl-5-methoxytryptamine) is a powerful antioxidant and ant-inflammatory agent synthesized from the essential amino acidl-tryptophan; it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. Melatonin has proven to be a potentially useful therapeutic tool in the reduction of graft rejection. Its benefits are based on its direct actions as a free radical scavenger as well as its indirect antioxidative actions in the stimulation of the cellular antioxidant defense system. Moreover, it has significant anti-inflammatory activity. Melatonin has been found to improve the beneficial effects of preservation fluids when they are enriched with the indoleamine. This article reviews the experimental evidence that melatonin is useful in reducing graft failure, especially in cardiac, bone, otolaryngology, ovarian, testicular, lung, pancreas, kidney, and liver transplantation.

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“…Several experimental strategies can be applied to either the donor or the graft. Pharmacological preconditioning was successfully used in rats with resulting reduced inflammatory responses, parenchymal dysfunction, and injury [55] . Heat-shock preconditioning is a method to induce endogenous protective heat-shock proteins by exposure to heat, and is applied 3-48 h before organ procurement [56] .…”

Section: Interventionsmentioning

confidence: 99%

Strategies to optimize the use of marginal donors in liver transplantation

Pezzati

Ghinolfi

Simone

et al. 2015

WJH

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Liver transplantation is the treatment of choice for end stage liver disease, but availability of liver grafts is still the main limitation to its wider use. Extended criteria donors (ECD) are considered not ideal for several reasons but their use has dramatically grown in the last decades in order to augment the donor liver pool. Due to improvement in surgical and medical strategies, results using grafts from these donors have become acceptable in terms of survival and complications; nevertheless a big debate still exists regarding their selection, discharge criteria and allocation policies. Many studies analyzed the use of these grafts from many points of view producing different or contradictory results so that accepted guidelines do not exist and the use of these grafts is still related to non-standardized policies changing from center to center. The aim of this review is to analyze every step of the donationtransplantation process emphasizing all those strategies, both clinical and experimental, that can optimize results using ECD.

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Multidrug donor preconditioning protects steatotic liver grafts against ischemia-reperfusion injury

Cited by 25 publications

References 45 publications

Effect of Hepatic Steatosis on Bioenergetic Function During Hepatic Ischemia-reperfusion: A Systematic Review

Effect of Hepatic Steatosis on Bioenergetic Function During Hepatic Ischemia-reperfusion: A Systematic Review

Potential benefits of melatonin in organ transplantation: a review

Strategies to optimize the use of marginal donors in liver transplantation

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