Multidomain drug delivery systems of β-casein micelles for the local oral co-administration of antiretroviral combinations

Chauhan, Prakram Singh; Abutbul-Ionita, Inbal; Halamish, Hen Moshe; Sosnik, Alejandro; Danino, Dganit

doi:10.1016/j.jcis.2020.12.021

Cited by 19 publications

(2 citation statements)

References 48 publications

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“…NaCN is also responsible for the sustained release of PTX at pH 5 and 7.4. Resveratrol or flutamide-loaded casein micelles exhibited similar results [ 78 ].…”

Section: Types Of Proteins Used As Micelles For Drug Deliverymentioning

confidence: 88%

Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers

et al. 2023

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Proteins-derived polymeric micelles have gained attention and revolutionized the biomedical field. Proteins are considered a favorable choice for developing micelles because of their biocompatibility, harmlessness, greater blood circulation and solubilization of poorly soluble drugs. They exhibit great potential in drug delivery systems as capable of controlled loading, distribution and function of loaded agents to the targeted sites within the body. Protein micelles successfully cross biological barriers and can be incorporated into various formulation designs employed in biomedical applications. This review emphasizes the recent advances of protein-based polymeric micelles for drug delivery to targeted sites of various diseases. Most studied protein-based micelles such as soy, gelatin, casein and collagen are discussed in detail, and their applications are highlighted. Finally, the future perspectives and forthcoming challenges for protein-based polymeric micelles have been reviewed with anticipated further advances.

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“…NaCN is also responsible for the sustained release of PTX at pH 5 and 7.4. Resveratrol or flutamide-loaded casein micelles exhibited similar results [ 78 ].…”

Section: Types Of Proteins Used As Micelles For Drug Deliverymentioning

confidence: 88%

Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers

et al. 2023

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“…[4] Many different oral drug delivery strategies have been investigated for co-delivery of multiple drugs in one dosage form, such as tablets, liposomes, 3D printed macrodevices, micro/nanoparticles, micelles, polymersomes, and dendrimers. [1,[5][6][7][8][9][10][11][12][13] Furthermore, co-delivery and sequential release of different pharmaceutical compounds from orally administered microcapsules has shown promising in vitro and in vivo results as an efficient strategy for the treatment of renal fibrosis. [14] Since 2012, polymeric microdevices with an inner reservoir for loading of drugs have attracted increasing attention for oral drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Sequential Drug Release Achieved with Dual‐Compartment Microcontainers: Toward Combination Therapy

Christfort

Milián‐Guimerá

Kamguyan

et al. 2022

Advanced Therapeutics

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Combination drug therapy is commonly used to treat cancer, diabetes, cardiovascular conditions, and infections. However, these therapies face challenges associated with patient compliance and toxicology. Over the past decades, microdevices have emerged as a promising candidate for oral delivery allowing for targeted drug delivery with a tunable drug release. In the present work, engineered and monodisperse dual‐compartment microdevices are developed to achieve a physical separation of two drugs followed by a sequential release in the gastrointestinal tract. As proof‐of‐concept, the compartments are sealed with two pH‐sensitive polymers of different thicknesses to control the sequential release of propranolol and furosemide. In vitro release studies and in vivo absorption studies in rats confirm a sequential drug release from the two compartments. Unlike other proposed approaches, it is highly advantageous that the drugs can be loaded directly as powders, and that their release can be tuned via optimized coatings to achieve the desired release and absorption profiles. Conclusively, this study lays a strong foundation for the future use of microdevices to enable co‐delivery of drugs followed by a sequential release in close proximity in the gastrointestinal tract.

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Nanomedicines to Improve Oral Delivery of Antiretroviral Drugs

Katari,

Jain

2023

AAPS Advances in the Pharmaceutical Sciences Series

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Multidomain drug delivery systems of β-casein micelles for the local oral co-administration of antiretroviral combinations

Cited by 19 publications

References 48 publications

Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers

Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers

Sequential Drug Release Achieved with Dual‐Compartment Microcontainers: Toward Combination Therapy

Nanomedicines to Improve Oral Delivery of Antiretroviral Drugs

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