Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects

Oral administration of tepoxalin in the horse: A PK/PD study

“…The high concentration of vehicle (DMSO 0.4%) used in the in vitro experimental design performed by Brideau and co-workers may account for this difference. In fact, it is well known that DMSO possesses anti-inflammatory activity, by inhibiting platelet aggregation induced by arachidonic acid in a concentration-dependent manner (Santos et al, 2003). After drug exposure, the production of TXB2 by platelets was significantly suppressed, but the production of PGE2 and LTB4 by LPS-and calciumstimulated white blood cells, respectively, was not significantly altered.…”

Adverse reactions during stem cell infusion in children treated with autologous and allogeneic stem cell transplantation

“…8 DMSO is essential for maintaining cell viability in the cryopreserved state but is toxic to cells when thawed and causes several ARs through histamine release resulting in cough, bronchospasm, hypotension, bradycardia and flushing. 25 Although many infusion-related ARs are attributable to DMSO, cellular therapy labs have established protocols to reduce this risk such as lowering the DMSO concentration to 5% in the final product, fractionated infusions and washing. 9 Many studies have shown a clear relationship between DMSO and incidence and/or severity of ARs.…”

Low temperature cell pausing: an alternative short-term preservation method for use in cell therapies including stem cell applications

“…Osmotic imbalances can injure cells and programmed cell death may be induced upon thawing (Mathew et al 2002). Further to this, dimethyl sulfoxide (DMSO), the most frequently used CPA, is considered toxic to cells at ambient temperatures (Hunt 2011) and may induce cell differentiation (Santos et al 2003). Patients infused with DMSO-preserved cells can also experience adverse reactions (Cox et al 2012).…”