Regenerative techniques for maxillofacial hard tissue reconstruction like other tissue engineering procedures is based on three principle elements; stem cells, scaffolds, and growth factors. The balanced scenario of bone induction and conduction is a critical issue in every bone regeneration procedure [1]. Current approaches used in clinical circumstances to reconstruct bony defects include different bone grafting methods, such as autologous bone grafts, allografts, bone-graft substitutes, distraction osteogenesis, and guided bone regeneration. Bone-graft substitutes have been developed to be used as scaffolds to promote cell migration, proliferation and differentiation for bone regeneration without need to violate other tissue from a donor site [2.[