Challenges in the Rehabilitation Handling of Large and Localized Oral and Maxillofacial Defects

Khojasteh, Arash; Hosseinpour, Sepanta

doi:10.1007/978-3-030-21583-5_11

Cited by 4 publications

(2 citation statements)

References 116 publications

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“…Bone defects in the oral and maxillofacial region are caused mainly by trauma, various pathology and their surgical treatment, and congenital situations that have functional, esthetic, and psychological effects on patients [7]. These defects remain a major health problem that commonly challenges oral and maxillofacial surgeons, scientists, and healthcare systems.…”

Section: Bonementioning

confidence: 99%

Damage in Dentistry

Franjić¹

2021

J Health Care and Research

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Dentistry is one of the clinical disciplines that is closely related to medicine, but also to the technology of making various devices and placing artificial materials that compensate and/or upgrade lost teeth and surrounding structures. Dentistry is also medically responsible for the treatment of patients with diseases of the oral cavity. The main task of dentistry is healthy teeth and oral cavity, ie their preservation and treatment of damaged teeth. Caries is the most common dental disease, and is caused by the multiplication of bacteria inside the oral cavity due to lack of oral hygiene. If not treated in time, caries penetrates deeper tooth structures and destroys them which leading to tooth decay. The most common symptoms of caries are tooth sensitivity and toothache. If these symptoms occur, it is necessary to perform an examination at the dentist in order to prevent the disease immediately at the beginning and to avoid significant consequences for dental health. If caries is not treated in time, there is a high chance that irreparable damage will occur to the teeth and tooth tissue, which can ultimately result in the loss of one or more teeth.

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Section: Bonementioning

confidence: 99%

Damage in Dentistry

Franjić¹

2021

J Health Care and Research

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“…4–7 Besides, they can develop a structure similar to bone tissue having extra cellular matrix termed as “in vitro bone tissue morphogenesis.” 4,8,9 Moreover, translation of bone tissue engineering to clinical practices has highlighted the demand for construction of large implants for critical-sized bone defects. 10–13 However, application of large grafts is mainly restricted due to limited penetration of cells into the structures, and inhomogeneous nutrient transport, which both reduce cell survival and proliferation within the core regions of the graft. 1,9,14–16 Bioreactor systems can facilitate the construction of functional bone grafts by reinforcing media convection around seeded cells and induction of flow-generated shear stimulation.…”

Section: Introductionmentioning

confidence: 99%

Computational modeling of media flow through perfusion-based bioreactors for bone tissue engineering

Nokhbatolfoghahaei

Bohlouli

Adavi

et al. 2020

Proc Inst Mech Eng H

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Bioreactor system has been used in bone tissue engineering in order to simulate dynamic nature of bone tissue environments. Perfusion bioreactors have been reported as the most efficient types of shear-loading bioreactor. Also, combination of forces, such as rotation plus perfusion, has been reported to enhance cell growth and osteogenic differentiation. Mathematical modeling using sophisticated infrastructure processes could be helpful and streamline the development of functional grafts by estimating and defining an effective range of bioreactor settings for better augmentation of tissue engineering. This study is aimed to conduct computational modeling for newly designed bioreactors in order to alleviate the time and material consuming for evaluating bioreactor parameters and effect of fluid flow hydrodynamics (various amounts of shear stress) on osteogenesis. Also, biological assessments were performed in order to validate similar parameters under implementing the perfusion or rotating and perfusion fluid motions in bioreactors’ prototype. Finite element method was used to investigate the effect of hydrodynamic of fluid flow inside the bioreactors. The equations used in the simulation to calculate the velocity values and consequently the shear stress values include Navier–Stokes and Brinkman equations. It has been shown that rotational fluid motion in rotating and perfusion bioreactor produces more velocity and shear stress compared with perfusion bioreactor. Moreover, implementing the perfusion together with rotational force in rotating and perfusion bioreactors has been shown to have more cell proliferation and higher activity of alkaline phosphatase enzyme as well as formation of extra cellular matrix sheet, as an indicator of bone-like tissue formation.

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Autogenous Block Bone Graft for Horizontal Ridge Augmentation in Implant Dentistry

2022

Essential Techniques of Alveolar Bone Augmentation in Implant Dentistry

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Challenges in the Rehabilitation Handling of Large and Localized Oral and Maxillofacial Defects

Cited by 4 publications

References 116 publications

Damage in Dentistry

Damage in Dentistry

Computational modeling of media flow through perfusion-based bioreactors for bone tissue engineering

Autogenous Block Bone Graft for Horizontal Ridge Augmentation in Implant Dentistry

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