Multidisciplinary approach to understand the pathogenesis of gastric cancer

Shang, Juan

doi:10.3748/wjg.v11.i27.4131

Cited by 35 publications

(26 citation statements)

References 62 publications

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“…Infection with strains possessing CagA is more common among people with peptic ulceration or gastric adenocarcinoma. Since CagA + infection may be associated with development of atrophic gastritis, CagA + infection is believed to be a risk factor for intestinal-type GC [14]. The 1DE western blotting technique is a very useful tool for seroepidemiological survey, since it detects both former and current H. pylori infection.…”

Section: Protein Virulence Factors and Diagnosis Of Infectionmentioning

confidence: 99%

Helicobacter pylori: immunoproteomics related to different pathologies

Bernardini¹,

Braconi²,

Lusini³

et al. 2007

Expert Review of Proteomics

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Helicobacter pylori is a Gram-negative bacterium that causes ulcer, atrophic gastritis, adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Moreover, an ongoing controversial role of this bacterium infection has been suggested in the etiopathogenesis of some extradigestive diseases. The humoral response to H. pylori during a natural infection can be used for diagnostic purposes and as a basis for vaccine development. Host-pathogen interactions may be investigated by means of immunoproteomics, which provides global information about relevant specific and nonspecific antigens, and thus might be suitable to identify novel vaccine candidates or serological markers of H. pylori infection as well as of different related diseases. In this review, we describe how several research groups used H. pylori proteomics combined with western blotting analysis, using sera from patients affected with different H. pylori-related pathologies, to investigate potential associations between host immune response and clinical outcomes of H. pylori infection, resulting in the rapid identification of novel, highly immunoreactive antigens.

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Section: Protein Virulence Factors and Diagnosis Of Infectionmentioning

confidence: 99%

Helicobacter pylori: immunoproteomics related to different pathologies

Bernardini¹,

Braconi²,

Lusini³

et al. 2007

Expert Review of Proteomics

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“…Gastric cancer is one of the most common causes of cancer-related death in China [1] . Its incidence in Jiangsu Province of China is particularly high, and its mortality rate is much higher than the national average [2] .…”

Section: Introductionmentioning

confidence: 99%

Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients

Jiang

Shen²,

Wu³

et al. 2010

WJG

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“…Gastric cancer is one of the most common causes of cancer death in China [1]. The early clinical detection of gastric cancer was less than 15%, and about 85% cases were advanced gastric cancer [2].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin

Jiang

Zheng

et al. 2011

PLoS ONE

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BackgroundThe goal of this study is to evaluate the effectiveness of S-1/Oxaliplatin vs. Doxifluridine/Oxaliplatin regimen and to identify miRNAs as potential prognostic biomarkers in gastric cancer patients. The expression of candidate miRNAs was quantified from fifty-five late stage gastric cancer FFPE specimens.Experimental DesignGastric cancer patients with KPS>70 were recruited for the trial. The control group was treated with 400 mg/twice/day Doxifluridine plus i.v. with Oxaliplatin at 130 mg/m2/first day/4 week cycle. The testing group was treated with S-1 at 40 mg/twice/day/4 week cycle plus i.v. with Oxaliplatin at 130 mg/m2/first day/4 week cycle. Total RNAs were extracted from normal and gastric tumor specimens. The levels of miRNAs were quantified using real time qRT-PCR expression analysis.ResultsThe overall objective response rate (CR+PR) of patients treated with S-1/Oxaliplatin was 33.3% (CR+PR) vs. 17.6% (CR+PR) with Doxifluridine/Oxaliplatin for advanced stage gastric cancer patients. The average overall survival for patients treated with S-1/Oxaliplatin was 7.80 month vs. 7.30 month with patients treated with Doxifluridine/Oxaliplatin. The expression of miR-181b (P = 0.022) and miR-21 (P = 0.0029) was significantly overexpressed in gastric tumors compared to normal gastric tissues. Kaplan-Meier survival analysis revealed that low levels of miR-21 expression (Log rank test, hazard ratio: 0.17, CI = 0.06–0.45; P = 0.0004) and miR-181b (Log rank test, hazard ratio: 0.37, CI = 0.16–0.87; P = 0.018) are closely associated with better patient's overall survival for both S-1 and Doxifluridine based regimens.ConclusionPatients treated with S-1/Oxaliplatin had a better response than those treated with Doxifluridine/Oxaliplatin. miR-21 and miR-181b hold great potential as prognostic biomarkers in late stage gastric cancer.

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Multidisciplinary approach to understand the pathogenesis of gastric cancer

Cited by 35 publications

References 62 publications

Helicobacter pylori: immunoproteomics related to different pathologies

Helicobacter pylori: immunoproteomics related to different pathologies

Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients

Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin

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