Multidimensional Assessment of Voice Characteristics After Radiotherapy for Early Glottic Cancer

Leeuw, Irma M. Verdonck‐de; Hilgers, Frans J. M.; Keus, Ronald B.; Beinum, Florien J. Koopmans–van; Greven, A. J.; Jong, J.M.A. de; Vreeburg, G. C. M.; Bartelink, Harry

doi:10.1097/00005537-199902000-00014

Cited by 62 publications

(47 citation statements)

References 18 publications

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“…Patients treated by endolaryngeal laser surgery did not rate their voice as poorer than those after radiotherapy. This stands in contrast with most objective voice evaluations comparing these treatment modalities [5,11,15,17]. The negative impact of radiotherapy on the ability of swallowing solid food and xerostomia was significant.…”

Section: Discussionmentioning

confidence: 71%

Quality of life after treatment for early laryngeal carcinoma

Stoeckli¹,

M²,

Schneider³

et al. 2001

European Archives of Oto-Rhino-Laryngology

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Radiotherapy and surgery for early laryngeal cancer achieve comparably good results in patient survival, and the choice of treatment between them is being influenced increasingly by the expected voice quality and quality of life (QoL). The superiority of vocal function after radiotherapy has been shown in previous objective voice assessment studies. This study compared the QoL of long-term survivors after endoscopic laser surgery or radiotherapy for early laryngeal carcinoma. QoL was evaluated with two validated questionnaires: the global EORTC QLQ-C30 and the head- and neck-specific EORTC QLQ-H&N35. A total of 62 patients were included. Among 56 patients completing the questionnaires (90% completion rate) 40 were treated by endoscopic CO2 laser surgery and 16 with radiation therapy. All 56 patients showed a good global QoL with no significant difference between the two treatment modalities. The head- and neck-specific evaluation revealed significantly better scores for surgically treated patients in questions about swallowing of solid food, xerostomia, and tooth problems, but no difference in questions about voice quality. Both treatment modalities achieve good QoL after treatment of early laryngeal tumors. Irradiated patients mainly complain about xerostomia related problems. In contrast to objective measurements long-term survivors after surgery do not rate their voice poorer than irradiated patients. The EORTC questionnaires are validated and useful tools in assessing QoL and should further be used in prospective trials.

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Section: Discussionmentioning

confidence: 71%

Quality of life after treatment for early laryngeal carcinoma

Stoeckli¹,

M²,

Schneider³

et al. 2001

European Archives of Oto-Rhino-Laryngology

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“…Voice impairment in patients after treatment for early glottic cancer has been reported in several studies, ranging from 14 to 92% of the patients [1,6,9,16,24,25]. Furthermore, several studies on the inXuence of voice problems on quality of life revealed that in 27 up to 58% of the patients experienced diYculties in communication abilities leading to a disrupted social life [3,8,12,17,[19][20][21][22]25].…”

Section: Introductionmentioning

confidence: 99%

“…To enable quick screening on voice problems, a short 5-item voicescreening questionnaire was developed and validated, which proved to be feasible in clinical practice [22]. A more detailed multidimensional voice analysis protocol is however recommended for monitoring voice intervention and for research purposes [24], including a structured questionnaire such as the Voice handicap index (VHI). The VHI is a validated 30-item questionnaire measuring psychosocial handicapping eVects of voice disorders [7] and is used in several studies on patients after treatment for early glottic cancer with mean VHI scores ranging from 12 to 34 points [3,8,12,19].…”

Section: Introductionmentioning

confidence: 99%

Voice in early glottic cancer compared to benign voice pathology

Gogh

Mahieu

Kuik

et al. 2007

Eur Arch Otorhinolaryngol

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The purpose of this study is to compare (Dutch) Voice Handicap Index (VHIvumc) scores from a selected group of patients with voice problems after treatment for early glottic cancer with patients with benign voice disorders and subjects from the normal population. The study included a group of 35 patients with voice problems after treatment for early glottic cancer and a group of 197 patients with benign voice disorders. Furthermore, VHI scores were collected from 123 subjects randomly chosen from the normal population. VHI reliability was high with high internal consistency and test-retest stability. VHI scores of glottic cancer patients were similar to those of patients with voice problems due to benign lesions. Both groups of patients were clearly deviant from the normal population. Within the normal population, 16% appeared to have not-normal voices. Based on ROC curves a cut-oV score of 15 points was deWned to identify patients with voice problems in daily life. A clinical relevant diVerence score of 10 points was deWned to be used for individual patients and of 15 points to be used in study designs with groups. Patients with voice problems after treatment for early glottic cancer encounter the same amount of problems in daily life as the other voiceimpaired patients. The VHI proved to be an adequate tool for baseline and eVectiveness measurement of voice.

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“…In fact, radiotherapy is often preferred because it seems to be associated with reduced impairment of voice quality, but qualitative studies about vocal function in post-irradiated patients have been inconclusive and not uniform [12,16,17,18,20,28,31,48,50]. In addition, disagreement among otolaryngologists, radiotherapists, and speech-language pathologists with respect to the functional results after radiotherapy still persists.…”

Section: Introductionmentioning

confidence: 99%

“…Radical radiotherapy and endoscopic laser surgery are established treatment modalities for early glottic cancer. Radiotherapy provides successful treatment results with local control rates between 80 and 92%, and a mean 5-year success rate of 85% in large studies [3,4,9,26,29,33,38,43,49,50,52,53,55]. On the other hand, surgical resection has been slightly higher, ranging between 88 and 94% and a mean rate of 90% in other larges studies [1,6,7,10,19,21,22,25,32,42,45].…”

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confidence: 97%