Multicomponent synthesis of pyrano[2,3-d]pyrimidine derivatives via a direct one-pot strategy executed by novel designed copperated Fe3O4@polyvinyl alcohol magnetic nanoparticles

Maleki, Ali; Niksefat, Maryam; Rahimi, Jamal; Taheri‐Ledari, Reza

doi:10.1016/j.mtchem.2019.05.001

Cited by 105 publications

(43 citation statements)

References 33 publications

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“…Subsequently, these Fe 3 O 4 NPs were coated with silica by hydrolyzing tetraethyl orthosilicate (TEOS) under mild conditions (2). [50][51][52] In the next step, PVA was dissolved in deionized water at 60 °C and added to the well-dispersed silica-coated magnetic NPs (3). Subsequently, PVA chains were functionalized with (3-mercaptopropyl) trimethoxysilane (MPTES) through its OH surface groups (4).…”

Section: Synthesis Of Au/fe 3 O 4 /Pva-10%dxlmentioning

confidence: 99%

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Taheri‐Ledari

Zhang

Radmanesh

et al. 2020

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To further improve the efficiencies of the established drugs, various treatment strategies, such as preparation of protein-drug conjugates and the design of nanoscale drug-carriers, are used to increase the efficacy of therapeutic agents. [6-8] Several effective nanocarrier systems were designed to deliver anti-cancer cytotoxic agents to tumor cells with high selectivity and efficacy while minimizing negative side effects. [9,10] Drug nano-carriers provide multiple advantages, such as convenient uptake and internalization, reduced drug interactions, optimized lifetime, and widened therapeutic windows. [11] In this regard, the synthetic design and applications of different types of iron oxide nanoparticles (Fe 3 O 4 NPs) have received significant attention since these NPs can be magnetically directed inside target tissues and their surface can be easily functionalized with diverse polymers and organic compounds. [12-16] Previously, we have reported several magnetic systems in micro-and nanoscale for diverse functional applications. [17-24] To further expand upon this work, we utilized one of the most commonly employed polymers, polyvinyl alcohol (PVA), to encapsulate magnetic Fe 3 O 4 NPs by virtue of its extended hydrogen bonding and to provide a selective release medium for DXL. [25] Drug molecules, such as DXL, can be incorporated into a PVA gel when polymer chains are in a shrunk state at low temperatures, and subsequently released in a target tissue upon a PVA transition into a swollen gel at 37 °C. [26] PVA features several important advantages. First is the ability to form a gel owing to multiple hydrogen bonding by OH groups. A versatile breast cancer-targeting nanocomposite therapeutic combining docetaxel (DXL), polyvinyl alcohol (PVA) network for controlled release, and silica-protected magnetic iron oxide nanoparticles (Fe 3 O 4 NPs) for targeted delivery and gold nanoparticles (AuNPs) for plasmonic photothermal therapy (PPTT) is presented in this work. First, the designed nanocomposite is magnetically directed for cancer-targeted therapy confirmed by computerized tomography (CT) scans. Second, 10% DXL by mass is loaded into PVA, a pH and temperature responsive gel, for controlled release. Third, PPTT is confirmed with Au/Fe 3 O 4 /PVA-10%DXL using a prototype circulation system and then for tumor treatment in vivo; Au/Fe 3 O 4 /PVA-10%DXL is conveniently directed and the entrapped DXL is selectively released (≈96%) via the interaction of green and near-infrared (NIR) light with the localized surface plasmon resonance of AuNPs. A 75% cell death is reported from in vitro studies with DXL doses as low as 20 µg mL −1 of Au/Fe 3 O 4 /PVA-10%DXL, and a 70% tumor growth inhibition is demonstrated by in vivo experiments with the biosafety studies confirming minimal side effects to other organs. Overall, the developed Au/Fe 3 O 4 /PVA-10%DXL has a strong potential to simultaneously enhance CT imaging contrast together with the targeted delivery of DXL.

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Section: Synthesis Of Au/fe 3 O 4 /Pva-10%dxlmentioning

confidence: 99%

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Taheri‐Ledari

Zhang

Radmanesh

et al. 2020

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100

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“…Many types of biomaterials [62][63][64] with different physicochemical properties can influence on cell migration on the 2D planar substrates [47,65]. However, three-dimensional materials are more capable of simulating the real cell niche in vivo, allowing the simultaneous interactions between cell-cell and cell-matrix.…”

Section: Discussionmentioning

confidence: 99%

Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

et al. 2020

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Cell migration plays a pivotal role in many pathological and physiological processes. So far, most of the studies have been focused on 2-dimensional cell adhesion and migration. Herein, the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization of methacrylated hyaluronic acid (HA-MA) and fibrinogen (Fg) with different ratios were studied. The Fg could be released to the medium gradually along with time prolongation, achieving the dynamic change of hydrogel structures and properties. Three types of cell spheroids, i.e., endothelial cell (EC), smooth muscle cell (SMC), and EC-SMC spheroids, were prepared with 10,000 cells in each, whose diameters were about 343, 108, and 224 μm, respectively. The composite hydrogels with an intermediate ratio of Fg allowed the fastest 3D migration of cell spheroids. The ECs-SMCs migrated longest up to 3200 μm at day 14, whereas the SMC spheroids migrated slowest with a distance of only ~400 μm at the same period of time. The addition of free RGD or anti-CD44 could significantly reduce the migration distance, revealing that the cell-substrate interactions take the major roles and the migration is mesenchymal dependent. Moreover, addition of anti-N-cadherin and MMP inhibitors also slowed down the migration rate, demonstrating that the degradation of hydrogels and cell-cell interactions are also largely involved in the cell migration. RT-PCR measurement showed that expression of genes related to cell adhesion and antiapoptosis, and angiogenesis was all upregulated in the EC-SMC spheroids than single EC or SMC spheroids, suggesting that the use of composite cell spheroids is more promising to promote cell-substrate interactions and maintenance of cell functions.

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“…For instance, we recently reported some novel magnetic nanoparticles (NPs) that have been functionalized and applied for different catalytic aims such as facilitating peptide couplings and multicomponent synthesis reactions of pharmaceutical compounds. 13,14 However, wide surface active area, great functionalization capability, nontoxicity, excellent stability and thermal resistance, and etc. could also be mentioned as the additional important reasons for employing the magnetic NPs for catalytic purposes.…”

Section: Introductionmentioning

confidence: 99%

High-performance sono/nano-catalytic system: CTSN/Fe₃O₄–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

2019

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Multicomponent synthesis of pyrano[2,3-d]pyrimidine derivatives via a direct one-pot strategy executed by novel designed copperated Fe3O4@polyvinyl alcohol magnetic nanoparticles

Cited by 105 publications

References 33 publications

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

High-performance sono/nano-catalytic system: CTSN/Fe₃O₄–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

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Multicomponent synthesis of pyrano[2,3-d]pyrimidine derivatives via a direct one-pot strategy executed by novel designed copperated Fe3O4@polyvinyl alcohol magnetic nanoparticles

Cited by 105 publications

References 33 publications

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

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High-performance sono/nano-catalytic system: CTSN/Fe₃O₄–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles