High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

Taheri‐Ledari, Reza; Hashemi, Seyed Masoud; Maleki, Ali

doi:10.1039/c9ra08062g

Cited by 63 publications

(37 citation statements)

References 26 publications

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“…Previously, we have reported several magnetic systems in micro‐ and nanoscale for diverse functional applications. [ 17–24 ] To further expand upon this work, we utilized one of the most commonly employed polymers, polyvinyl alcohol (PVA), to encapsulate magnetic Fe 3 O 4 NPs by virtue of its extended hydrogen bonding and to provide a selective release medium for DXL. [ 25 ] Drug molecules, such as DXL, can be incorporated into a PVA gel when polymer chains are in a shrunk state at low temperatures, and subsequently released in a target tissue upon a PVA transition into a swollen gel at 37 °C.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Taheri‐Ledari

Zhang

Radmanesh

et al. 2020

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To further improve the efficiencies of the established drugs, various treatment strategies, such as preparation of protein-drug conjugates and the design of nanoscale drug-carriers, are used to increase the efficacy of therapeutic agents. [6-8] Several effective nanocarrier systems were designed to deliver anti-cancer cytotoxic agents to tumor cells with high selectivity and efficacy while minimizing negative side effects. [9,10] Drug nano-carriers provide multiple advantages, such as convenient uptake and internalization, reduced drug interactions, optimized lifetime, and widened therapeutic windows. [11] In this regard, the synthetic design and applications of different types of iron oxide nanoparticles (Fe 3 O 4 NPs) have received significant attention since these NPs can be magnetically directed inside target tissues and their surface can be easily functionalized with diverse polymers and organic compounds. [12-16] Previously, we have reported several magnetic systems in micro-and nanoscale for diverse functional applications. [17-24] To further expand upon this work, we utilized one of the most commonly employed polymers, polyvinyl alcohol (PVA), to encapsulate magnetic Fe 3 O 4 NPs by virtue of its extended hydrogen bonding and to provide a selective release medium for DXL. [25] Drug molecules, such as DXL, can be incorporated into a PVA gel when polymer chains are in a shrunk state at low temperatures, and subsequently released in a target tissue upon a PVA transition into a swollen gel at 37 °C. [26] PVA features several important advantages. First is the ability to form a gel owing to multiple hydrogen bonding by OH groups. A versatile breast cancer-targeting nanocomposite therapeutic combining docetaxel (DXL), polyvinyl alcohol (PVA) network for controlled release, and silica-protected magnetic iron oxide nanoparticles (Fe 3 O 4 NPs) for targeted delivery and gold nanoparticles (AuNPs) for plasmonic photothermal therapy (PPTT) is presented in this work. First, the designed nanocomposite is magnetically directed for cancer-targeted therapy confirmed by computerized tomography (CT) scans. Second, 10% DXL by mass is loaded into PVA, a pH and temperature responsive gel, for controlled release. Third, PPTT is confirmed with Au/Fe 3 O 4 /PVA-10%DXL using a prototype circulation system and then for tumor treatment in vivo; Au/Fe 3 O 4 /PVA-10%DXL is conveniently directed and the entrapped DXL is selectively released (≈96%) via the interaction of green and near-infrared (NIR) light with the localized surface plasmon resonance of AuNPs. A 75% cell death is reported from in vitro studies with DXL doses as low as 20 µg mL −1 of Au/Fe 3 O 4 /PVA-10%DXL, and a 70% tumor growth inhibition is demonstrated by in vivo experiments with the biosafety studies confirming minimal side effects to other organs. Overall, the developed Au/Fe 3 O 4 /PVA-10%DXL has a strong potential to simultaneously enhance CT imaging contrast together with the targeted delivery of DXL.

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Section: Introductionmentioning

confidence: 99%

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Taheri‐Ledari

Zhang

Radmanesh

et al. 2020

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“…Recently, we have found out that the function of these heterogeneous catalytic systems could be greatly enhanced by applying the ultrasound waves. In our previous reports, we comprehensively discussed the substantial synergistic catalytic effect between the magnetic nanoparticles (MNPs) and the ultrasound waves with a determined frequency and power density 18–20 . Concisely, ultrasonication leads to obtain high reaction yield during a short reaction time, under a milder condition.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell‐penetrating peptide: An efficient sonochemical catalytic process

Taheri‐Ledari

Maleki

2020

Journal of Peptide Science

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Herein, we make an effort to enhance the antimicrobial activity of levofloxacin (LVX) antibiotic via conjugation to a cell‐penetrating peptide (CPP) including Cys‐Gly‐Ala‐Phe‐Pro‐His‐Arg. For this purpose, cysteine is used as a linker between the LVX and CPP chain, and two heterogeneous nanoscale catalytic systems are employed as the substantial alternatives for traditional peptide coupling reagents like N,N,N′,N′‐tetramethyl‐O‐(benzotriazol‐1‐yl)uronium tetrafluoroborate (TBTU). Briefly, it has been found out that the antimicrobial potency of the synthesized CPP‐LVX conjugate (on the gram‐positive and gram‐negative bacteria) is noticeably enhanced (~20% more). It has been revealed via zone of inhibition (ZOI) and optical density (OD) evaluations. As a convenient method for making this type of the effective conjugations, ultrasound waves (with a specific frequency and power density) activate the catalytic sites of the heterogeneous nanoparticles. Through this synergistic effect, peptide/amide bond is formed during a short time (10 min), and high reaction yield (>90%) is obtained under mild conditions. Moreover, as a simple purification process, the catalyst nanoparticles are collected and separated through their high magnetic property.

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“…and Lv et al ., respectively Previously, we have shown that magnetic nanoparticles act as instrumental tools for catalytic applications due to high ease in the separation and purification processes …”

Section: Introductionmentioning

confidence: 99%

Convenient Cr(VI) Removal from Aqueous Samples: Executed by a Promising Clay‐Based Catalytic System, Magnetized by Fe₃O₄ Nanoparticles and Functionalized with Humic Acid

et al. 2020

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Here, a nanoscale efficient adsorbent for chromium(VI) ion is presented, which is constructed of halloysite nanotubes (HNTs) as a natural basis. On the other hand, to add magnetic property, iron oxide (Fe3O4) nanoparticles have been incorporated inside and leaded onto the surface of HNTs. As the main component of nanoabsorbent, humic acid (HA) is also loaded onto the surface of HNT/Fe3O4 nanocomposite. Cr(VI) removal process has been carefully monitored in the presence of the fabricated HNT/Fe3O4‐HA nanoabsorbent from aqueous solutions with different concentrations of K2CrO4. The adsorption isotherms are interpreted by Langmuir graphs, and 98% removal efficiency (RE) has been obtained at room temperature, in 15 min contact time. Additionally, all the analyses related to the structure of desired product have been done, and the recyclability of produced nanoabsorbent is precisely investigated, as well.

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High-performance sono/nano-catalytic system: CTSN/Fe₃O₄–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

Abstract: High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles with high yields.

Cited by 63 publications

References 26 publications

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell‐penetrating peptide: An efficient sonochemical catalytic process

Convenient Cr(VI) Removal from Aqueous Samples: Executed by a Promising Clay‐Based Catalytic System, Magnetized by Fe₃O₄ Nanoparticles and Functionalized with Humic Acid

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High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

Abstract: High-performance sono/nano-catalytic system: CTSN/Fe3O4–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles with high yields.

Cited by 63 publications

References 26 publications

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell‐penetrating peptide: An efficient sonochemical catalytic process

Convenient Cr(VI) Removal from Aqueous Samples: Executed by a Promising Clay‐Based Catalytic System, Magnetized by Fe3O4 Nanoparticles and Functionalized with Humic Acid

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High-performance sono/nano-catalytic system: CTSN/Fe₃O₄–Cu nanocomposite, a promising heterogeneous catalyst for the synthesis of N-arylimidazoles

Convenient Cr(VI) Removal from Aqueous Samples: Executed by a Promising Clay‐Based Catalytic System, Magnetized by Fe₃O₄ Nanoparticles and Functionalized with Humic Acid