Multicomponent One-Pot Synthesis of Substituted Hantzsch Thiazole Derivatives Under Solvent Free Conditions

Dawane, Bhaskar S.; Konda, Shankaraiah G.; Kamble, Vinod T.; Chavan, Sanjay A.; Bhosale, Raghunath B.; Baseer, M.Shaikh

doi:10.1155/2009/752580

Cited by 16 publications

(9 citation statements)

References 3 publications

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“…The high activity of analogue 83 in cells can be ascribed to the lack of binding competition with the high levels of intracellular ATP. The kinase selectivity profile exhibited that compound 83 was also about 40 times higher than that of CX-4945 (5-(3-chlorophenylamino)-benzo[c] [2,6]naphthyridine-8-carboxylic acid, silmitasertib). The pharmacological profile of the 2-aminothiazolyl benzoic acid derivatives will be different from any ATP-competitive CK2 inhibitor, which was valuable for further investigation in in vivo models.…”

Section: Modification Of 2-amine To 2-arylaminomentioning

confidence: 99%

“…2-aminothiazole scaffold has emerged as a promising scaffold in medicinal chemistry and drug discovery research considering its broad pharmacological spectrum [6]. Literature survey documented that 2-aminothiazole derivatives represent a class of heterocyclic ring system that possess antiviral [7], antimicrobial [8], anticancer [9], anticonvulsant [10], antidiabetic [11], antihypertensive [12], antileishmanial [13], and anti-inflammatory activities [14].…”

Section: Introductionmentioning

confidence: 99%

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Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Alizadeh

Hashemi

2021

Med Chem Res

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Currently, the development of anticancer drug resistance is significantly restricted the clinical efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely prevalent and considered to be the major challenges of this century, which concerns the medical community all over the world. Consequently, investigating small molecule antitumor agents, which could decrease drug resistance and reduce unpleasant side effect is more desirable. 2-aminothiazole scaffold has emerged as a promising scaffold in medicinal chemistry and drug discovery research. This nucleus is a fundamental part of some clinically applied anticancer drugs such as dasatinib and alpelisib. Literature survey documented that different 2aminothiazole analogs exhibited their potent and selective nanomolar inhibitory activity against a wide range of human cancerous cell lines such as breast, leukemia, lung, colon, CNS, melanoma, ovarian, renal, and prostate. In this paper, we have reviewed the progresses and structural modification of 2-aminothiazole to pursuit potent anticancers and also highlighted in vitro activities and in silico studies. The information will useful for future innovation.

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Section: Modification Of 2-amine To 2-arylaminomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Alizadeh

Hashemi

2021

Med Chem Res

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“…Presently, available second line drugs are not very effective and moreover, cause side effects and therefore it is necessary to identify novel drug targets. Thiazole derivatives display a wide range of biological activities such as cardiotonic, fungicidal, sedative, anesthetic, bactericidal, and anti-inflammatory [26,27]. In addition, thiazole derivatives are reported to show a variety of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Some Novelthiazol Derivatives of N-((2-Chlorophenyl)diphenylmethyl)-4-Phenylthiazol-2-Amine

Limbasiya¹,

Babariya²,

Jilariya

et al. 2022

JASR

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In present work we synthesized novel series of thiazole derivatives of N-((2-chlorophenyl)diphenylmethyl)-4- phenylthiazol-2-amine in the presence of dichloromethane and triethylamine in good yield. The different studies indicate that newly synthesized compounds possess moderate to good biological activities. The title compounds have been synthesized with several structural variations. Biological evaluation of all the synthesized compounds has been carried out in vitro for their antibacterial and antifungal efficacy against various bacterial and fungal strains. The structure of synthesized compounds were characterized by their spectral (IR, 1H NMR and Mass) data.

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“…Furthermore, thiazole derivatives have attracted a great deal of interest due to their wide applications in the field of pharmaceuticals. Thiazole derivatives display a wide range of biological activities such as cardiotonic, fungicidal, sedative, anesthetic, bactericidal, and anti-inflammatory [26,27]. In addition, thiazole derivatives are reported to show a variety of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling

El‐Sattar

El‐Naggar

Abdel‐Mottaleb

2017

Journal of Chemistry

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This paper reports on the synthesis of new thiazole derivatives that could be profitably exploited in medical treatment of tumors. Molecular electronic structures have been modeled within density function theory (DFT) framework. Reactivity indices obtained from the frontier orbital energies as well as electrostatic potential energy maps are discussed and correlated with the molecular structure. X-ray crystallographic data of one of the new compounds is measured and used to support and verify the theoretical results.

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Multicomponent One-Pot Synthesis of Substituted Hantzsch Thiazole Derivatives Under Solvent Free Conditions

Abstract: Thiazole derivatives were prepared by one-pot procedure by the reaction ofα-haloketones, thiourea and substitutedo-hydroxybenzaldehyde under environmentally solvent free conditions.

Cited by 16 publications

References 3 publications

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Synthesis, Characterization and Biological Evaluation of Some Novelthiazol Derivatives of N-((2-Chlorophenyl)diphenylmethyl)-4-Phenylthiazol-2-Amine

Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling

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