In present work we synthesized novel series of thiazole derivatives of N-((2-chlorophenyl)diphenylmethyl)-4- phenylthiazol-2-amine in the presence of dichloromethane and triethylamine in good yield. The different studies indicate that newly synthesized compounds possess moderate to good biological activities. The title compounds have been synthesized with several structural variations. Biological evaluation of all the synthesized compounds has been carried out in vitro for their antibacterial and antifungal efficacy against various bacterial and fungal strains. The structure of synthesized compounds were characterized by their spectral (IR, 1H NMR and Mass) data.
In this work, pyrazole based oxothiazolidine hybrids, 4-{4-[2-(1-
phenyl-3-(substituted)phenyl-1H-pyrazol-4-yl)-4-oxo-thiazolidin-3-
yl]-phenyl}-morpholin-3-one (11a-l) were synthesized using molecular
hybridization approach through Vilsmeier-Haack reaction. The titled
compounds 11a-l were characterized by elemental analysis, IR, 1H NMR
and mass spectral studies. The antibacterial activity of 11a-l was evaluated
in vitro by agar cup plate method against B. cocous, B. subtillis, E. coli
and P. vulgaris. The antifungal activity of compounds 11a-l was
evaluated in vitro by agar based disk diffusion method against A.
niger. The results of antibacterial and antifungal evaluation were
reported in terms of zone of inhibition measured in mm. The
synthesized compounds 11a-l exhibited moderate to good antibacterial
and antifungal potential. Compound 4-{4-[2-(1-phenyl-3-(2-methoxyphenyl)
phenyl-1H-pyrazol-4-yl)-4-oxo-thiazolidin-3-yl]-phenyl}-
morpholin-3-one (11h) emerged as a most potent antimicrobial agent
displaying zone of inhibition 21, 20, 21, 24 and 20 mm against B.
cocous, B. subtillis, E. coli, P. vulgaris and A. niger, respectively.
A highly functionalized heterocyclic compounds series were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel synthetic route involves Schiff base formation reaction of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. All the synthesized compounds were characterized using IR, 1H NMR and mass spectroscopic techniques. All the compound screened for antimicrobial activity against standard drugs.
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