Multicomponent gas analysis using broadband quantum cascade laser spectroscopy

Reyes-Reyes, A.; Hou, Zongyu; Mastrigt, Esther van; Horsten, Roland; Jongste, Johan C. de; Pijnenburg, Mariëlle; Urbach, H. P.; Bhattacharya, Nandini

doi:10.1364/oe.22.018299

Cited by 16 publications

(21 citation statements)

References 21 publications

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“…The setup has a noise equivalent absorbance sensitivity of 2.99 × 10 −7 cm −1 Hz −1/2 and its capability to detect sub-ppmv concentrations of acetone has been demonstrated. 26 Here the subscript i accounts for the discrete nature of the scan. The multipass cell allows to obtain an effective interaction distance of l = 54.36 m between the gas samples and the laser in a volume of only 0.6 L. The signal acquired by the MCT detectors is processed to obtain a normalized transmission spectrum of the multipass cell.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…Furthermore, the sensitivity can be improved by increasing the interaction length inside the multipass cell and using one single detector to produced the normalized transmission spectrum. 26 The future of diagnostic methods based on acetone concentrations in exhaled breath is highly promising. By combining our setup with recently develop methods to exclusively trap acetone, 11 we can increase the sensitivity of our system and boost the performance of laser-based devices for breath analysis.…”

Section: ■ Conclusionmentioning

confidence: 99%

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Study of the Exhaled Acetone in Type 1 Diabetes Using Quantum Cascade Laser Spectroscopy

et al. 2014

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The acetone concentration exhaled in the breath of three type 1 diabetes patients (two minors and one adult) and one healthy volunteer is studied using a quantum cascade laser-based spectroscopic system. Using the acetone signature between 1150 and 1250 cm(-1) and a multiline fitting method, the concentration variations on the order of parts per billion by volume were measured. Blood glucose and ketone concentrations in blood measurements were performed simultaneously to study their relation with acetone in exhaled breath. We focus on personalized studies to better understand the role of acetone in diabetes. For each volunteer, we performed a series of measurements over a period of time, including overnight fastings of 11 ± 1 h and during ketosis-hyperglycemia events for the minors. Our results highlight the importance of performing personalized studies because the response of the minors to the presence of ketosis was consistent but unique for each individual. Also, our results emphasize the need for performing more studies with T1D minors, because the acetone concentration in the breath of the minors differs, with respect to those reported in the literature, which are based on adults.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Conclusionmentioning

confidence: 99%

Study of the Exhaled Acetone in Type 1 Diabetes Using Quantum Cascade Laser Spectroscopy

et al. 2014

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“…154 Reyes-Reyes et al employed a pulsed EC-QCL operated between 830 and 1250 cm À1 in combination with a 55 m multipass transmission cell and a balanced detection scheme for multicomponent gas analysis. 166 Concentration determination was possible for molecules with a broad spectral profile such as acetone and ethanol but was impaired for species with sharp spectral features such as carbon dioxide. This setup was used in a clinical study of children with asthma and cystic fibrosis.…”

Section: Qcl-ir Spectroscopy For Breath Analysismentioning

confidence: 99%

Quantum cascade lasers (QCLs) in biomedical spectroscopy

2017

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Quantum cascade lasers (QCL) are the first room temperature semiconductor laser source for the mid-IR spectral region, triggering substantial development for the advancement of mid-IR spectroscopy. Mid-IR spectroscopy in general provides rapid, label-free and objective analysis, particularly important in the field of biomedical analysis. Due to their unique properties, QCLs offer new possibilities for development of analytical methods to enable quantification of clinically relevant concentration levels and to support medical diagnostics. Compared to FTIR spectroscopy, novel and elaborated measurement techniques can be implemented that allow miniaturized and portable instrumentation. This review illustrates the characteristics of QCLs with a particular focus on their benefits for biomedical analysis. Recent applications of QCL-based spectroscopy for analysis of a variety of clinically relevant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized. Further potential for technical advancements is discussed in combination with future prospects for employment of QCL-based devices in routine and point-of-care diagnostics.

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“…Today, laser-based sensing of chemical species offers high sensitivity and specificity, large dynamic range, multi-component capability, and lack of pretreatment or preconcentration. The availability of broadly tunable mid-infrared sources – particularly in the important 3–4 μm wavelength range – such as quantum cascade lasers (QCLs) [1–4] , tunable radiation generated by nonlinear optical processes such as difference frequency generation (DFG) [5,6] and optical parametric oscillators (OPOs) [5,7,8] , interband cascade diode lasers (ICLs) [9–11] , distributed feedback (DFB) diode lasers [12,13] , or the most recent development of diode-pumped lead salt vertical external cavity surface emitting lasers (VECSELs) [14,15] has certainly eased the implementation of laser-based sensing devices.…”

Section: Introductionmentioning

confidence: 99%